| Tag | Content |
|---|---|
| Uniprot ID | Q62521; A2AWK3; Q3UYV1; Q8BSB3; |
| Entrez ID | 22773 |
| Genbank protein ID | BAA11116.1; BAC28831.1; EDL42177.1; EDL42178.1; BAE22110.1; |
| Genbank nucleotide ID | NM_009575.2 |
| Ensembl protein ID | ENSMUSP00000085999; ENSMUSP00000086001; |
| Ensembl nucleotide ID | ENSMUSG00000067860 |
| Gene name | Zinc finger protein ZIC 3 |
| Gene symbol | Zic3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 23184148 |
| Functional description | Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. |
| Sequence | MTMLLDGGPQ FPGLGVGSFG APRHHEMPNR EPAGMGLNPF GDSTHAAAAA AAAAAFKLSP 60 ATAHDLSSGQ SSAFTPQGSG YANALGHHHH HHHHHHASQV PTYGGAASAA FNSTRDFLFR 120 QRGSGLSEAA SGGGQHGLFA GSASSLHAPA GIPEPPSYLL FPGLHEQGAG HPSPTGHVDN 180 NQVHLGLRGE LFGRADPYRP VASPRTDPYA ASAQFPNYSP MNMNMGVNVA AHHGPGAFFR 240 YMRQPIKQEL SCKWIEEAQL SRPKKSCDRT FSTMHELVTH VTMEHVGGPE QNNHVCYWEE 300 CPREGKSFKA KYKLVNHIRV HTGEKPFPCP FPGCGKIFAR SENLKIHKRT HTGEKPFKCE 360 FEGCDRRFAN SSDRKKHMHV HTSDKPYICK VCDKSYTHPS SLRKHMKVHE SQGSDSSPAA 420 SSGYESSTPP AIASANSKDT TKTPSAVQTS TSHNPGLPPN FNEWYV 466 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ZIC3 | 541035 | E1BJR9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ZIC3 | 492171 | E2R969 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ZIC3 | 102177783 | A0A452FJL7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ZIC3 | 7547 | O60481 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Zic3 | 22773 | Q62521 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ZIC3 | 740302 | A0A2I3RP19 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ZIC3 | 100156863 | F1RQ88 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | ZIC3 | 100347605 | G1TFC7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Zic3 | 367944 | A0A096MIX7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | zic3 | 368263 | Q6PV84 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | ISO |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IDA |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IBA |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | ISO |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA |
| GO:0003700 | DNA-binding transcription factor activity | ISO |
| GO:0003700 | DNA-binding transcription factor activity | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0043565 | sequence-specific DNA binding | ISS |
| GO:0043565 | sequence-specific DNA binding | ISO |
| GO:0046872 | metal ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001947 | heart looping | ISO |
| GO:0001947 | heart looping | IMP |
| GO:0001947 | heart looping | IGI |
| GO:0007368 | determination of left/right symmetry | ISO |
| GO:0007368 | determination of left/right symmetry | IMP |
| GO:0007368 | determination of left/right symmetry | IGI |
| GO:0007389 | pattern specification process | IMP |
| GO:0007417 | central nervous system development | IBA |
| GO:0009952 | anterior/posterior pattern specification | IGI |
| GO:0030154 | cell differentiation | IEA |
| GO:0030324 | lung development | ISO |
| GO:0035469 | determination of pancreatic left/right asymmetry | ISO |
| GO:0035545 | determination of left/right asymmetry in nervous system | IMP |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO:0071907 | determination of digestive tract left/right asymmetry | ISO |
| GO:0071910 | determination of liver left/right asymmetry | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0010 | Activator |
| KW-0025 | Alternative splicing |
| KW-0963 | Cytoplasm |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-0238 | DNA-binding |
| KW-1017 | Isopeptide bond |
| KW-0479 | Metal-binding |
| KW-0524 | Neurogenesis |
| KW-0539 | Nucleus |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0804 | Transcription |
| KW-0805 | Transcription regulation |
| KW-0832 | Ubl conjugation |
| KW-0862 | Zinc |
| KW-0863 | Zinc-finger |