| Tag | Content |
|---|---|
| Uniprot ID | Q6PV84 |
| Entrez ID | 368263 |
| Genbank protein ID | AAU03477.1; AAT01219.1; AAH96991.1; |
| Genbank nucleotide ID | NM_001001950.2 |
| Ensembl protein ID | ENSDARP00000096539 |
| Ensembl nucleotide ID | ENSDARG00000071497 |
| Gene name | ZIC family member 3 heterotaxy 1 (Odd-paired homolog, Drosophila) |
| Gene symbol | zic3 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTMLLDSAPQ FPSLGVGGFG TPRHHELGNR DPGLGLSPFA DSSHSAAFKI SPVTHDIASS 60 QTSAFTPQAT GYAAALGHHH GGQVGSYAGG AFNSTRDFLF RNRGAGIGET APPSAQHGIF 120 AASAGSLHGP PGISDNPGHL LFPGLHDQSV SHTSPGGHVV NSQMHLGLRG DIFGRPDPYR 180 PVASPRTEPY GAAPLHNYNH PINMNMGMNV PTHHGPGAFF RYMRQPIKQE LSCKWIDENQ 240 MNRPKKTCDR TFSTMHEMVT HVSMEHVGGP EQSNHVCYWE DCPREGKSFK AKYKLVNHIR 300 VHTGEKPFPC PFPGCGKIFA RSENLKIHKR THTGEKPFKC EFDGCDRRFA NSSDRKKHMH 360 VHTSDKPYIC KVCDKSYTHP SSLRKHMKVH ESQGSESSPA ASSGYESSTP PVLVSANTED 420 PTKTPTSAVQ NSSAHSDGLP PNFNEWYV 448 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ZIC3 | 541035 | E1BJR9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ZIC3 | 492171 | E2R969 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ZIC3 | 102177783 | A0A452FJL7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ZIC3 | 7547 | O60481 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Zic3 | 22773 | Q62521 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ZIC3 | 740302 | A0A2I3RP19 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ZIC3 | 100156863 | F1RQ88 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | ZIC3 | 100347605 | G1TFC7 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Zic3 | 367944 | A0A096MIX7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | zic3 | 368263 | Q6PV84 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0046872 | metal ion binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0009948 | anterior/posterior axis specification |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0007417 | central nervous system development |
| GO:0007368 | determination of left/right symmetry |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0006357 | regulation of transcription by RNA polymerase II |