| Tag | Content |
|---|---|
| Uniprot ID | P54728; Q3TUA4; |
| Entrez ID | 19359 |
| Genbank protein ID | BAE36124.1; AAH27747.1; BAE36067.1; CAA63146.1; BAE29298.1; BAE36071.1; |
| Genbank nucleotide ID | NM_009011.4 |
| Ensembl protein ID | ENSMUSP00000030134 |
| Ensembl nucleotide ID | ENSMUSG00000028426 |
| Gene name | UV excision repair protein RAD23 homolog B |
| Gene symbol | Rad23b |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 11809813 |
| Functional description | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. |
| Sequence | MQVTLKTLQQ QTFKIDIDPE ETVKALKEKI ESEKGKDAFP VAGQKLIYAG KILSDDTALK 60 EYKIDEKNFV VVMVTKPKAV TTAVPATTQP SSTPSPTAVS SSPAVAAAQA PAPTPALPPT 120 STPASTAPAS TTASSEPAPA GATQPEKPAE KPAQTPVLTS PAPADSTPGD SSRSNLFEDA 180 TSALVTGQSY ENMVTEIMSM GYEREQVIAA LRASFNNPDR AVEYLLMGIP GDRESQAVVD 240 PPPQAVSTGT PQSPAVAAAA ATTTATTTTT SGGHPLEFLR NQPQFQQMRQ IIQQNPSLLP 300 ALLQQIGREN PQLLQQISQH QEHFIQMLNE PVQEAGSQGG GGGGGGGGGG GGGGGIAEAG 360 SGHMNYIQVT PQEKEAIERL KALGFPEGLV IQAYFACEKN ENLAANFLLQ QNFDED 416 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RAD23B | 530189 | Q29RK4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RAD23B | 481656 | E2R4A5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | RAD23B | 102183790 | A0A452FP98 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RAD23B | 5887 | P54727 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Rad23b | 19359 | P54728 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | RAD23B | 473012 | K7BCM9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 100153668 | A0A480DNV8 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | RAD23B | 100353489 | G1SST9 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Rad23b | 298012 | Q4KMA2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | rad23b | 393536 | A0A2R8PYT0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IDA |
| GO:0003684 | damaged DNA binding | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0031593 | polyubiquitin modification-dependent protein binding | ISO |
| GO:0031593 | polyubiquitin modification-dependent protein binding | IBA |
| GO:0043130 | ubiquitin binding | IBA |
| GO:0044212 | transcription regulatory region DNA binding | IDA |
| GO:0070628 | proteasome binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000715 | nucleotide-excision repair, DNA damage recognition | ISO |
| GO:0006289 | nucleotide-excision repair | ISO |
| GO:0006974 | cellular response to DNA damage stimulus | IDA |
| GO:0007283 | spermatogenesis | IMP |
| GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | ISO |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IBA |
| GO:0048568 | embryonic organ development | IEA |
| GO:0098761 | cellular response to interleukin-7 | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000502 | proteasome complex | IEA |
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005654 | nucleoplasm | IBA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005829 | cytosol | ISO |
| GO:0005829 | cytosol | IBA |
| GO:0071942 | XPC complex | ISS |
| GO:0071942 | XPC complex | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-446203 | Asparagine N-linked glycosylation | IEA |
| R-MMU-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | IEA |
| R-MMU-5688426 | Deubiquitination | IEA |
| R-MMU-5689877 | Josephin domain DUBs | IEA |
| R-MMU-5696394 | DNA Damage Recognition in GG-NER | IEA |
| R-MMU-5696395 | Formation of Incision Complex in GG-NER | IEA |
| R-MMU-5696398 | Nucleotide Excision Repair | IEA |
| R-MMU-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-73894 | DNA Repair | IEA |