| Tag | Content |
|---|---|
| Uniprot ID | Q29RK4 |
| Entrez ID | 530189 |
| Genbank protein ID | AAI14134.1 |
| Genbank nucleotide ID | NM_001046310.1 |
| Ensembl protein ID | ENSBTAP00000002506 |
| Ensembl nucleotide ID | ENSBTAG00000001926 |
| Gene name | UV excision repair protein RAD23 homolog B |
| Gene symbol | RAD23B |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (By similarity). |
| Sequence | MLVTLKTLQQ QTFKIDIDPD ETVRALKEKI ESEKGKDAFP VAGQKLIYAG KILNDDTALK 60 EYKIDEKNFV VVMVTKPKAV TTPAPATTQQ SNSAATTTVS SSTAPAVTQA PAPAPASAPT 120 PTPVSVTPAP TTASSEPAPA SAAKQEKPAE RPVETPVATT PTSTDSTSGD SSRSNLFEDA 180 TSALVTGQSY ENMVTEIMSM GYEREQVIAA LRASFNNPDR AVEYLLMGIP GDRESQAVVD 240 PPPAASTGAP QSSVAAAAAT TTATTTTTSS GGHPLEFLRN QPQFQQMRQI IQQNPSLLPA 300 LLQQIGRENP QLLQQISQHQ EHFIQMLNEP VQEAGGQGGG GGGGSGGIAE AGGGHMNYIQ 360 VTPQEKEAIE RLKALGFPEG LVIQAYFACE KNENLAANFL LQQNFDED 408 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RAD23B | 530189 | Q29RK4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RAD23B | 481656 | E2R4A5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | RAD23B | 102183790 | A0A452FP98 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RAD23B | 5887 | P54727 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Rad23b | 19359 | P54728 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | RAD23B | 473012 | K7BCM9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 100153668 | A0A480DNV8 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | RAD23B | 100353489 | G1SST9 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Rad23b | 298012 | Q4KMA2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | rad23b | 393536 | A0A2R8PYT0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0042025 | host cell nucleus |
| GO:0005654 | nucleoplasm |
| GO:0000502 | proteasome complex |
| GO:0071942 | XPC complex |
| GO:0003684 | damaged DNA binding |
| GO:0031593 | polyubiquitin modification-dependent protein binding |
| GO:0070628 | proteasome binding |
| GO:0043130 | ubiquitin binding |
| GO:0006289 | nucleotide-excision repair |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |