| Tag | Content |
|---|---|
| Uniprot ID | Q4KMA2; Q0D2G8; Q5CZZ8; Q6IRD5; |
| Entrez ID | 298012 |
| Genbank protein ID | AAI11407.1; AAH70960.1; AAH98674.1; AAH90351.1; |
| Genbank nucleotide ID | NM_001025275.1 |
| Ensembl protein ID | ENSRNOP00000021629 |
| Ensembl nucleotide ID | ENSRNOG00000016137 |
| Gene name | UV excision repair protein RAD23 homolog B |
| Gene symbol | Rad23b |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (By similarity). |
| Sequence | MQVTLKTLQQ QTFKIDIDPE ETVKALKEKI ESEKGKDAFP VAGQKLIYAG KILSDDTALK 60 EYKIDEKNFV VVMVTKPKAV TSAVPATTQQ SSSPSTTTVS SSPAAAVAQA PAPTPALAPT 120 STPASTTPAS TTASSEPAPT GATQPEKPAE KPAQTPVLTS PAPADSTPGD SSRSNLFEDA 180 TSALVTGQSY ENMVTEIMSM GYEREQVIAA LRASFNNPDR AVEYLLMGIP GDRESQAVVD 240 PPPQAVSTGT PQSPAVAAAA ATTTATTTTT SGGHPLEFLR NQPQFQQMRQ IIQQNPSLLP 300 ALLQQIGREN PQLLQQISQH QEHFIQMLNE PVQEAGGQGG GGGGGGGGGG GGGGIAEAGS 360 GHMNYIQVTP QEKEAIERLK ALGFPEGLVI QAYFACEKNE NLAANFLLQQ NFDED 415 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RAD23B | 530189 | Q29RK4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RAD23B | 481656 | E2R4A5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | RAD23B | 102183790 | A0A452FP98 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RAD23B | 5887 | P54727 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Rad23b | 19359 | P54728 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | RAD23B | 473012 | K7BCM9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 100153668 | A0A480DNV8 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | RAD23B | 100353489 | G1SST9 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Rad23b | 298012 | Q4KMA2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | rad23b | 393536 | A0A2R8PYT0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0042025 | host cell nucleus |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0000502 | proteasome complex |
| GO:0071942 | XPC complex |
| GO:0003684 | damaged DNA binding |
| GO:0031593 | polyubiquitin modification-dependent protein binding |
| GO:0070628 | proteasome binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0043130 | ubiquitin binding |
| GO:0006974 | cellular response to DNA damage stimulus |
| GO:0098761 | cellular response to interleukin-7 |
| GO:0048568 | embryonic organ development |
| GO:0006289 | nucleotide-excision repair |
| GO:0000715 | nucleotide-excision repair, DNA damage recognition |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:0007283 | spermatogenesis |