Gene Page: SAE1

Summary ?
GeneID10055
SymbolSAE1
SynonymsAOS1|HSPC140|SUA1|UBLE1A
DescriptionSUMO1 activating enzyme subunit 1
ReferenceMIM:613294|HGNC:HGNC:30660|Ensembl:ENSG00000142230|HPRD:18010|Vega:OTTHUMG00000183464
Gene typeprotein-coding
Map location19q13.32
Pascal p-value0.11
Sherlock p-value0.595
Fetal beta0.747
DMG1 (# studies)
SupportG2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg160415501947633739SAE13.318E-40.3760.041DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZXDC0.910.87
CD2760.910.87
ABL10.900.85
CCNJ0.900.85
MOBKL2A0.900.87
EPHB20.900.85
DLG50.900.83
EHMT10.900.85
ZNF3190.890.86
ZNF5320.890.86
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.68-0.81
AF347015.31-0.67-0.81
MT-CO2-0.66-0.81
C5orf53-0.65-0.69
AF347015.8-0.64-0.80
MT-CYB-0.64-0.79
AF347015.33-0.64-0.77
AF347015.15-0.62-0.78
HLA-F-0.61-0.62
AIFM3-0.60-0.62

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CYP1B1CP1B | GLC3A | P4501B1cytochrome P450, family 1, subfamily B, polypeptide 1Affinity Capture-MSBioGRID17353931 
FKBP4FKBP52 | FKBP59 | HBI | Hsp56 | PPIase | p52FK506 binding protein 4, 59kDaAffinity Capture-MSBioGRID17353931 
KIAA1409FLJ43337KIAA1409Affinity Capture-MSBioGRID17353931 
RANBP2NUP358 | TRP1 | TRP2RAN binding protein 2Biochemical ActivityBioGRID11792325 
RANGAP1Fug1 | KIAA1835 | MGC20266 | SDRan GTPase activating protein 1-HPRD9920803 
SP100DKFZp686E07254 | FLJ00340 | FLJ34579SP100 nuclear antigenBiochemical ActivityBioGRID11792325 
SUMO1DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)Reconstituted ComplexBioGRID12924945 
SUMO1DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)-HPRD10187858 
SUMO3SMT3A | SMT3H1 | SUMO-3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
SUMO3SMT3A | SMT3H1 | SUMO-3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)-HPRD12924945 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD15327968 
UBA2ARX | FLJ13058 | HRIHFB2115 | SAE2ubiquitin-like modifier activating enzyme 2Sua1 interacts with hUba2.BIND9920803 
UBA2ARX | FLJ13058 | HRIHFB2115 | SAE2ubiquitin-like modifier activating enzyme 2Affinity Capture-MS
Biochemical Activity
in vitro
Two-hybrid		BioGRID10187858 |10217437 
|16189514 |17353931 
UBA2ARX | FLJ13058 | HRIHFB2115 | SAE2ubiquitin-like modifier activating enzyme 2-HPRD9920803 |10187858 
|10217437 
UBA2ARX | FLJ13058 | HRIHFB2115 | SAE2ubiquitin-like modifier activating enzyme 2SAE1 interacts with SAE2. This interaction was modeled on a demonstrated interaction between SAE1 from an unspecified species and SAE2 from an unspecified species.BIND15546615 
UBE2E3UBCH9 | UbcM2ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)-HPRD10187858 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Affinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 13898All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251156All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212129All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP 14686All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290177All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378231All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228137All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
ZUCCHI METASTASIS UP 4324All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN 6444All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210124All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277172All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 181101All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway