SZGR2

Summary ?

GeneID	10253
Symbol	SPRY2
Synonyms	IGAN3\|hSPRY2
Description	sprouty RTK signaling antagonist 2
Reference	MIM:602466\|HGNC:HGNC:11270\|Ensembl:ENSG00000136158\|HPRD:03916\|Vega:OTTHUMG00000017140
Gene type	protein-coding
Map location	13q31.1
Pascal p-value	0.613
Sherlock p-value	0.472
Fetal beta	-0.452

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SLC25A39	0.88	0.88
SHARPIN	0.86	0.86
GPS1	0.86	0.85
VKORC1	0.85	0.81
GSTP1	0.85	0.81
SH3BGRL3	0.84	0.84
COPE	0.84	0.85
COQ4	0.83	0.82
GNB2	0.82	0.78
MRPS2	0.81	0.79

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.27	-0.52	-0.57
AF347015.8	-0.51	-0.55
MT-CYB	-0.50	-0.55
AF347015.31	-0.50	-0.53
MT-CO2	-0.50	-0.53
MT-ATP8	-0.49	-0.60
AF347015.33	-0.49	-0.53
AF347015.2	-0.48	-0.54
AF347015.15	-0.47	-0.52
AF347015.26	-0.46	-0.52

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0009966	regulation of signal transduction	IEA		-
GO:0007267	cell-cell signaling	TAS		9458049
GO:0009887	organ morphogenesis	TAS		9458049
GO:0007605	sensory perception of sound	IEA		-
GO:0007275	multicellular organismal development	IEA		-
GO:0042472	inner ear morphogenesis	IEA		-
GO:0048754	branching morphogenesis of a tube	IEA		-
GO:0030324	lung development	IEA		-
GO:0043407	negative regulation of MAP kinase activity	IEA		-
GO:0045165	cell fate commitment	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		12593796
GO:0005874	microtubule	IEA		-
GO:0005737	cytoplasm	IEA		-
GO:0005886	plasma membrane	EXP		15962011
GO:0005886	plasma membrane	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADAMTSL4	TSRC1	ADAMTS-like 4	Two-hybrid	BioGRID	16189514
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD,BioGRID	11053437 \|12234920
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	c-Cbl interacts with hSpry2. This interaction was modeled on a demonstrated interaction between c-Cbl from an unspecified species and human hSpry2.	BIND	12234920
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	SPRY2 interacts with c-Cbl.	BIND	11053437
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	hSpry2 interacts with c-Cbl.	BIND	12815057
CBLB	DKFZp686J10223 \| DKFZp779A0729 \| DKFZp779F1443 \| FLJ36865 \| FLJ41152 \| Nbla00127 \| RNF56	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	SPRY2 interacts with Cbl-b.	BIND	11053437
CBLC	CBL-3 \| CBL-SL \| RNF57	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	-	HPRD	12234920
GPRIN2	GRIN2 \| KIAA0514 \| MGC15171	G protein regulated inducer of neurite outgrowth 2	Two-hybrid	BioGRID	16189514
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	10940627 \|12402043
KRTAP4-12	KAP4.12 \| KRTAP4.12	keratin associated protein 4-12	Two-hybrid	BioGRID	16189514
PLSCR1	MMTRA1B	phospholipid scramblase 1	Two-hybrid	BioGRID	16189514
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	Affinity Capture-Western	BioGRID	12717443
SPRYD5	MGC10977 \| TRIM51	SPRY domain containing 5	Two-hybrid	BioGRID	16189514
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG JAK STAT SIGNALING PATHWAY	155	105	All SZGR 2.0 genes in this pathway
BIOCARTA SPRY PATHWAY	18	15	All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY	41	35	All SZGR 2.0 genes in this pathway
PID FGF PATHWAY	55	37	All SZGR 2.0 genes in this pathway
REACTOME SPRY REGULATION OF FGF SIGNALING	14	9	All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING	37	24	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME EGFR DOWNREGULATION	25	14	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN	384	220	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP	177	110	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN	384	230	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP	233	161	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE UP	79	50	All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL DN	118	79	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA DN	284	156	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP	194	112	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN	229	142	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN DN	172	112	All SZGR 2.0 genes in this pathway
AMUNDSON GENOTOXIC SIGNATURE	105	68	All SZGR 2.0 genes in this pathway
DAWSON METHYLATED IN LYMPHOMA TCL1	59	45	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN	156	106	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN	110	78	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP	142	104	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP	236	139	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MS UP	48	32	All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2	39	29	All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN	53	34	All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS DN	120	69	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP	476	285	All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN	80	66	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
LEE SP4 THYMOCYTE	14	11	All SZGR 2.0 genes in this pathway
LEE RECENT THYMIC EMIGRANT	227	128	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
NIELSEN LEIOMYOSARCOMA CNN1 DN	20	18	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL	162	122	All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE DN	103	67	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE	317	190	All SZGR 2.0 genes in this pathway
BILANGES SERUM AND RAPAMYCIN SENSITIVE GENES	68	35	All SZGR 2.0 genes in this pathway
WINZEN DEGRADED VIA KHSRP	100	70	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4	227	149	All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF	516	308	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	494	500	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	494	500	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	494	500	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	382	388	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	382	388	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-21	236	243	1A,m8	hsa-miR-21^brain	UAGCUUAUCAGACUGAUGUUGA
miR-21	236	243	1A,m8	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
miR-23	458	465	1A,m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	458	465	1A,m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-27	382	389	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	382	389	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-323	458	464	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-326	337	343	1A	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-369-3p	428	434	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	428	434	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-378	10	16	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-381	359	365	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: SPRY2