Gene Page: STUB1

Summary ?
GeneID10273
SymbolSTUB1
SynonymsCHIP|HSPABP2|NY-CO-7|SCAR16|SDCCAG7|UBOX1
DescriptionSTIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
ReferenceMIM:607207|HGNC:HGNC:11427|Ensembl:ENSG00000103266|HPRD:06232|Vega:OTTHUMG00000121140
Gene typeprotein-coding
Map location16p13.3
Pascal p-value0.033
Sherlock p-value0.364
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0239 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf40.880.87
PLA2G160.880.85
SGK20.870.84
MOG0.870.85
ERBB30.870.87
SLC48A10.870.85
RHBDL20.860.81
LDB30.860.84
PADI20.860.84
DBNDD20.860.86
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NKIRAS2-0.61-0.61
KIAA1949-0.60-0.60
TUBB2B-0.60-0.64
HN1-0.60-0.63
YBX1-0.60-0.68
PPP1R14B-0.60-0.71
HMGB3-0.60-0.65
MPP3-0.59-0.57
FNBP1L-0.58-0.59
DYNLT1-0.58-0.70

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004842ubiquitin-protein ligase activityTAS16307917 
GO:0016874ligase activityIEA-
GO:0010546Hsp90 protein inhibitor activityIDA11146632 
GO:0030674protein binding, bridgingTAS16307917 
GO:0030544Hsp70 protein bindingIDA10330192 
GO:0030544Hsp70 protein bindingTAS16307917 
GO:0042803protein homodimerization activityIEA-
GO:0030911TPR domain bindingIDA11146632 
GO:0030191Hsp70/Hsc70 protein inhibitor activityIDA10330192 
GO:0046332SMAD bindingIDA15781469 
GO:0051879Hsp90 protein bindingIDA11146632 
GO:0051879Hsp90 protein bindingTAS16307917 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000209protein polyubiquitinationIDA15781469 
GO:0006457protein foldingTAS16307917 
GO:0031943regulation of glucocorticoid metabolic processIDA11146632 
GO:0051604protein maturationTAS16307917 
GO:0031398positive regulation of protein ubiquitinationIDA11146632 
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processIDA11146632 
GO:0030579ubiquitin-dependent SMAD protein catabolic processIDA15781469 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000151ubiquitin ligase complexIEA-
GO:0005737cytoplasmIDA10330192 
GO:0031371ubiquitin conjugating enzyme complexTAS16307917 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAG1RAP46BCL2-associated athanogene-HPRD,BioGRID11676916 
DNAJB1HSPF1 | Hdj1 | Hsp40 | Sis1DnaJ (Hsp40) homolog, subfamily B, member 1-HPRD,BioGRID10330192 
GPR37EDNRBL | PAELR | hET(B)R-LPG protein-coupled receptor 37 (endothelin receptor type B-like)-HPRD,BioGRID12150907 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD11146632|11557750 
HSPA1AFLJ54303 | FLJ54370 | FLJ54392 | FLJ54408 | FLJ75127 | HSP70-1 | HSP70-1A | HSP70I | HSP72 | HSPA1 | HSPA1Bheat shock 70kDa protein 1A-HPRD,BioGRID10330192 
HSPA4APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RYheat shock 70kDa protein 4in vitro
in vivo
Two-hybrid		BioGRID10330192 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD,BioGRID10330192 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8The TPR and charged domains of CHIP interact with the carboxy-terminal region of Hsc70.BIND10330192 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1Two-hybridBioGRID16169070 
MPP1AAG12 | DXS552 | DXS552E | EMP55 | MRG1 | PEMPmembrane protein, palmitoylated 1, 55kDaTwo-hybridBioGRID16169070 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1Smad1 interacts with CHIP. This interaction was modeled on a demonstrated interaction between Smad1 and CHIP, both from an unspecified species.BIND15708501 
SMAD4DPC4 | JIP | MADH4SMAD family member 4Smad4 interacts with CHIP. This interaction was modeled on a demonstrated interaction between Smad1 and CHIP, both from an unspecified species.BIND15708501 
UBE2D1E2(17)KB1 | SFT | UBC4/5 | UBCH5 | UBCH5Aubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)-HPRD11557750 
UBE2D2E2(17)KB2 | PUBC1 | UBC4 | UBC4/5 | UBCH5Bubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)Reconstituted ComplexBioGRID11676916 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 13898All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY 3325All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 10178All SZGR 2.0 genes in this pathway
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 2313All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 2616All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 6342All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251156All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212129All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285181All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310188All SZGR 2.0 genes in this pathway
HU ANGIOGENESIS UP 2116All SZGR 2.0 genes in this pathway
BERTUCCI INVASIVE CARCINOMA DUCTAL VS LOBULAR UP 2517All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 16P13 AMPLICON 12049All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 181101All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295155All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS UP 8451All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367231All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 10772All SZGR 2.0 genes in this pathway