SZGR2

Summary ?

GeneID	10289
Symbol	EIF1B
Synonyms	GC20
Description	eukaryotic translation initiation factor 1B
Reference	HGNC:HGNC:30792\|Ensembl:ENSG00000114784\|HPRD:17032\|Vega:OTTHUMG00000131388
Gene type	protein-coding
Map location	3p22.1
Pascal p-value	0.223
Sherlock p-value	0.117
Fetal beta	0.526
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.059

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg04019128	3	40350888	EIF1B	1.3E-9	-0.012	1.35E-6	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003743	translation initiation factor activity	IEA		-
GO:0005515	protein binding	IPI		17353931
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006446	regulation of translational initiation	TAS		7904817

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACAT1	ACAT \| MAT \| T2 \| THIL	acetyl-Coenzyme A acetyltransferase 1	Affinity Capture-MS	BioGRID	17353931
ACTR3	ARP3	ARP3 actin-related protein 3 homolog (yeast)	Affinity Capture-MS	BioGRID	17353931
EIF2S1	EIF-2 \| EIF-2A \| EIF-2alpha \| EIF2 \| EIF2A	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	Affinity Capture-MS	BioGRID	17353931
EIF2S3	EIF2 \| EIF2G \| EIF2gamma \| eIF-2gA	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	Affinity Capture-MS	BioGRID	17353931
EIF3A	EIF3 \| EIF3S10 \| KIAA0139 \| P167 \| TIF32 \| eIF3-p170 \| eIF3-theta \| p180 \| p185	eukaryotic translation initiation factor 3, subunit A	Affinity Capture-MS	BioGRID	17353931
EIF3D	EIF3S7 \| MGC126526 \| MGC17258 \| eIF3-p66 \| eIF3-zeta	eukaryotic translation initiation factor 3, subunit D	Affinity Capture-MS	BioGRID	17353931
EIF3E	EIF3-P48 \| EIF3S6 \| INT6 \| eIF3-p46	eukaryotic translation initiation factor 3, subunit E	Affinity Capture-MS	BioGRID	17353931
EIF3EIP	EIF3S11 \| EIF3S6IP \| HSPC021 \| HSPC025 \| MSTP005	eukaryotic translation initiation factor 3, subunit E interacting protein	Affinity Capture-MS	BioGRID	17353931
EIF3F	EIF3S5 \| eIF3-p47	eukaryotic translation initiation factor 3, subunit F	Affinity Capture-MS	BioGRID	17353931
EIF3G	EIF3-P42 \| EIF3S4 \| eIF3-delta \| eIF3-p44	eukaryotic translation initiation factor 3, subunit G	Affinity Capture-MS	BioGRID	17353931
EIF3H	EIF3S3 \| MGC102958 \| eIF3-gamma \| eIF3-p40	eukaryotic translation initiation factor 3, subunit H	Affinity Capture-MS	BioGRID	17353931
EIF3I	EIF3S2 \| PRO2242 \| TRIP-1 \| TRIP1 \| eIF3-beta \| eIF3-p36	eukaryotic translation initiation factor 3, subunit I	Affinity Capture-MS	BioGRID	17353931
EIF3K	ARG134 \| EIF3-p28 \| EIF3S12 \| HSPC029 \| M9 \| MSTP001 \| PLAC-24 \| PLAC24 \| PRO1474 \| PTD001	eukaryotic translation initiation factor 3, subunit K	Affinity Capture-MS	BioGRID	17353931
EIF3M	B5 \| FLJ29030 \| GA17 \| PCID1 \| hfl-B5	eukaryotic translation initiation factor 3, subunit M	Affinity Capture-MS	BioGRID	17353931
ERH	DROER \| FLJ27340	enhancer of rudimentary homolog (Drosophila)	Affinity Capture-MS	BioGRID	17353931
HPRT1	HGPRT \| HPRT	hypoxanthine phosphoribosyltransferase 1	Affinity Capture-MS	BioGRID	17353931
MRCL3	MLCB \| MRLC3	myosin regulatory light chain MRCL3	Affinity Capture-MS	BioGRID	17353931
PCMT1	-	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Affinity Capture-MS	BioGRID	17353931
RAB7A	FLJ20819 \| PRO2706 \| RAB7	RAB7A, member RAS oncogene family	Affinity Capture-MS	BioGRID	17353931
RPA3	REPA3	replication protein A3, 14kDa	Affinity Capture-MS	BioGRID	17353931
RPS11	-	ribosomal protein S11	Affinity Capture-MS	BioGRID	17353931
RPS29	-	ribosomal protein S29	Affinity Capture-MS	BioGRID	17353931
RPS3A	FTE1 \| MFTL \| MGC23240	ribosomal protein S3A	Affinity Capture-MS	BioGRID	17353931
RPS9	-	ribosomal protein S9	Affinity Capture-MS	BioGRID	17353931
SHMT2	GLYA \| SHMT	serine hydroxymethyltransferase 2 (mitochondrial)	Affinity Capture-MS	BioGRID	17353931
TAGLN2	HA1756 \| KIAA0120	transgelin 2	Affinity Capture-MS	BioGRID	17353931
TCEB1	SIII	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	Affinity Capture-MS	BioGRID	17353931
TSR1	FLJ10534 \| KIAA1401 \| MGC131829	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
YARS	CMTDIC \| TYRRS \| YRS \| YTS	tyrosyl-tRNA synthetase	Affinity Capture-MS	BioGRID	17353931

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR DN	167	100	All SZGR 2.0 genes in this pathway
BIDUS METASTASIS DN	161	93	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN	110	78	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN	169	112	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
HU GENOTOXIC DAMAGE 24HR	35	22	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP	244	151	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE DN	51	28	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP	245	159	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP	198	128	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10	69	38	All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP	242	159	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-299-5p	304	310	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-494	223	229	m8	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: EIF1B