Gene Page: TUBA1B

Summary ?
GeneID10376
SymbolTUBA1B
SynonymsK-ALPHA-1
Descriptiontubulin alpha 1b
ReferenceMIM:602530|HGNC:HGNC:18809|Ensembl:ENSG00000123416|HPRD:03960|Vega:OTTHUMG00000170410
Gene typeprotein-coding
Map location12q13.12
Pascal p-value0.228
Sherlock p-value0.573
Fetal beta-0.33
DMG1 (# studies)
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg142175341249525474TUBA1B2.06E-9-0.0141.65E-6DMG:Jaffe_2016
cg213005611249525534TUBA1B6.66E-8-0.011.64E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PRR120.970.98
ZNF7460.960.97
SF10.960.96
PHF120.950.96
PPP1R100.950.96
LSM14B0.950.96
CREBBP0.950.97
CCDC1200.950.96
KDM2B0.950.96
USP420.950.96
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.77-0.90
MT-CO2-0.76-0.90
S100B-0.75-0.85
C5orf53-0.74-0.78
AF347015.33-0.74-0.84
AF347015.27-0.73-0.86
FXYD1-0.73-0.85
MT-CYB-0.73-0.85
HIGD1B-0.72-0.87
COPZ2-0.71-0.79

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CUL4A-cullin 4AAffinity Capture-MSBioGRID12481031 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD11826099 
GRM7FLJ40498 | GLUR7 | GPRC1G | MGLUR7 | mGlu7glutamate receptor, metabotropic 7-HPRD11953448 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD7651436 
NFKBIAIKBA | MAD-3 | NFKBInuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha-HPRD9372968 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD,BioGRID7592789 
PXNFLJ16691paxillin-HPRD10840040 
RBX1BA554C12.1 | MGC13357 | MGC1481 | RNF75 | ROC1ring-box 1Affinity Capture-MSBioGRID12481031 
SIAH1FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1seven in absentia homolog 1 (Drosophila)-HPRD11146551 
SKISKVv-ski sarcoma viral oncogene homolog (avian)Ski interacts with alpha-tubulin.BIND15806149 
SNAP91AP180 | CALM | DKFZp781O0519 | KIAA0656synaptosomal-associated protein, 91kDa homolog (mouse)-HPRD12750376 
STARD13DLC2 | FLJ37385 | GT650StAR-related lipid transfer (START) domain containing 13STARD13 (RhoGAP) interacts with K-ALPHA-1 (alpha-tubulin).BIND14697242 
TUBG1TUBG | TUBGCP1tubulin, gamma 1-HPRD11082048 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GAP JUNCTION 9068All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION 5936All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY 2317All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY 3427All SZGR 2.0 genes in this pathway
PID HDAC CLASSIII PATHWAY 2520All SZGR 2.0 genes in this pathway
REACTOME PROTEIN FOLDING 5330All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 2211All SZGR 2.0 genes in this pathway
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY 1910All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285181All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201125All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309191All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP 15184All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS TOP50 UP 3827All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372227All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 11662All SZGR 2.0 genes in this pathway
MEINHOLD OVARIAN CANCER LOW GRADE DN 2016All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 DN 6638All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229137All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS UP 2716All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209139All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
PETRETTO CARDIAC HYPERTROPHY 3426All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK 169111All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151103All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY TBH AND H2O2 3624All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215132All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
AMUNDSON GAMMA RADIATION RESISTANCE 2014All SZGR 2.0 genes in this pathway
HONMA DOCETAXEL RESISTANCE 3423All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS UP 11271All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294199All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN 175103All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163102All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251151All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway