Gene Page: ECI2
Summary ?
| GeneID | 10455 |
| Symbol | ECI2 |
| Synonyms | ACBD2|DRS-1|DRS1|HCA88|PECI|dJ1013A10.3 |
| Description | enoyl-CoA delta isomerase 2 |
| Reference | MIM:608024|HGNC:HGNC:14601|Ensembl:ENSG00000198721|HPRD:16269|Vega:OTTHUMG00000014158 |
| Gene type | protein-coding |
| Map location | 6p24.3 |
| Pascal p-value | 0.018 |
| Sherlock p-value | 0.446 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
| Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10080424 | 6 | 4079581 | ECI2 | ENSG00000198721.8 | 1.811E-6 | 0.01 | 56250 | gtex_brain_ba24 |
| rs62394175 | 6 | 4104898 | ECI2 | ENSG00000198721.8 | 9.189E-7 | 0.01 | 30933 | gtex_brain_ba24 |
| rs1359321 | 6 | 4107486 | ECI2 | ENSG00000198721.8 | 1.027E-6 | 0.01 | 28345 | gtex_brain_ba24 |
| rs1815510 | 6 | 4108754 | ECI2 | ENSG00000198721.8 | 7.091E-7 | 0.01 | 27077 | gtex_brain_ba24 |
| rs2326403 | 6 | 4108932 | ECI2 | ENSG00000198721.8 | 1.43E-6 | 0.01 | 26899 | gtex_brain_ba24 |
| rs1832059 | 6 | 4113219 | ECI2 | ENSG00000198721.8 | 1.43E-6 | 0.01 | 22612 | gtex_brain_ba24 |
| rs71553907 | 6 | 4118979 | ECI2 | ENSG00000198721.8 | 2.148E-6 | 0.01 | 16852 | gtex_brain_ba24 |
| rs9503919 | 6 | 4118984 | ECI2 | ENSG00000198721.8 | 1.43E-6 | 0.01 | 16847 | gtex_brain_ba24 |
| rs9503922 | 6 | 4121333 | ECI2 | ENSG00000198721.8 | 7.091E-7 | 0.01 | 14498 | gtex_brain_ba24 |
| rs3177253 | 6 | 4133855 | ECI2 | ENSG00000198721.8 | 3.243E-7 | 0.01 | 1976 | gtex_brain_ba24 |
| rs35071107 | 6 | 4135225 | ECI2 | ENSG00000198721.8 | 2.115E-7 | 0.01 | 606 | gtex_brain_ba24 |
| rs45529732 | 6 | 4135262 | ECI2 | ENSG00000198721.8 | 1.307E-6 | 0.01 | 569 | gtex_brain_ba24 |
| rs13437317 | 6 | 4145203 | ECI2 | ENSG00000198721.8 | 1.642E-6 | 0.01 | -9372 | gtex_brain_ba24 |
| rs62394175 | 6 | 4104898 | ECI2 | ENSG00000198721.8 | 1.321E-8 | 0 | 30933 | gtex_brain_putamen_basal |
| rs6597031 | 6 | 4106370 | ECI2 | ENSG00000198721.8 | 1.619E-7 | 0 | 29461 | gtex_brain_putamen_basal |
| rs619873 | 6 | 4107455 | ECI2 | ENSG00000198721.8 | 4.82E-9 | 0 | 28376 | gtex_brain_putamen_basal |
| rs1359321 | 6 | 4107486 | ECI2 | ENSG00000198721.8 | 1.195E-8 | 0 | 28345 | gtex_brain_putamen_basal |
| rs1815510 | 6 | 4108754 | ECI2 | ENSG00000198721.8 | 1.59E-8 | 0 | 27077 | gtex_brain_putamen_basal |
| rs2326403 | 6 | 4108932 | ECI2 | ENSG00000198721.8 | 4.884E-9 | 0 | 26899 | gtex_brain_putamen_basal |
| rs649725 | 6 | 4109593 | ECI2 | ENSG00000198721.8 | 2.79E-9 | 0 | 26238 | gtex_brain_putamen_basal |
| rs853416 | 6 | 4113047 | ECI2 | ENSG00000198721.8 | 1.327E-9 | 0 | 22784 | gtex_brain_putamen_basal |
| rs853417 | 6 | 4113123 | ECI2 | ENSG00000198721.8 | 2.123E-10 | 0 | 22708 | gtex_brain_putamen_basal |
| rs1832059 | 6 | 4113219 | ECI2 | ENSG00000198721.8 | 3.231E-9 | 0 | 22612 | gtex_brain_putamen_basal |
| rs620484 | 6 | 4114211 | ECI2 | ENSG00000198721.8 | 2.123E-10 | 0 | 21620 | gtex_brain_putamen_basal |
| rs634698 | 6 | 4114247 | ECI2 | ENSG00000198721.8 | 2.123E-10 | 0 | 21584 | gtex_brain_putamen_basal |
| rs633290 | 6 | 4114788 | ECI2 | ENSG00000198721.8 | 2.496E-9 | 0 | 21043 | gtex_brain_putamen_basal |
| rs617790 | 6 | 4115758 | ECI2 | ENSG00000198721.8 | 2.697E-9 | 0 | 20073 | gtex_brain_putamen_basal |
| rs7166 | 6 | 4116262 | ECI2 | ENSG00000198721.8 | 1.327E-9 | 0 | 19569 | gtex_brain_putamen_basal |
| rs397746811 | 6 | 4117314 | ECI2 | ENSG00000198721.8 | 2.424E-8 | 0 | 18517 | gtex_brain_putamen_basal |
| rs2783073 | 6 | 4118674 | ECI2 | ENSG00000198721.8 | 1.327E-9 | 0 | 17157 | gtex_brain_putamen_basal |
| rs584585 | 6 | 4118789 | ECI2 | ENSG00000198721.8 | 2.123E-10 | 0 | 17042 | gtex_brain_putamen_basal |
| rs71553907 | 6 | 4118979 | ECI2 | ENSG00000198721.8 | 1.145E-8 | 0 | 16852 | gtex_brain_putamen_basal |
| rs9503919 | 6 | 4118984 | ECI2 | ENSG00000198721.8 | 3.231E-9 | 0 | 16847 | gtex_brain_putamen_basal |
| rs659025 | 6 | 4119051 | ECI2 | ENSG00000198721.8 | 2.123E-10 | 0 | 16780 | gtex_brain_putamen_basal |
| rs7757606 | 6 | 4119704 | ECI2 | ENSG00000198721.8 | 2.123E-10 | 0 | 16127 | gtex_brain_putamen_basal |
| rs7744628 | 6 | 4119996 | ECI2 | ENSG00000198721.8 | 1.327E-9 | 0 | 15835 | gtex_brain_putamen_basal |
| rs9328220 | 6 | 4120181 | ECI2 | ENSG00000198721.8 | 1.327E-9 | 0 | 15650 | gtex_brain_putamen_basal |
| rs693953 | 6 | 4120565 | ECI2 | ENSG00000198721.8 | 1.327E-9 | 0 | 15266 | gtex_brain_putamen_basal |
| rs613260 | 6 | 4120567 | ECI2 | ENSG00000198721.8 | 1.327E-9 | 0 | 15264 | gtex_brain_putamen_basal |
| rs613709 | 6 | 4120683 | ECI2 | ENSG00000198721.8 | 4.057E-10 | 0 | 15148 | gtex_brain_putamen_basal |
| rs9503922 | 6 | 4121333 | ECI2 | ENSG00000198721.8 | 5.736E-10 | 0 | 14498 | gtex_brain_putamen_basal |
| rs629362 | 6 | 4121831 | ECI2 | ENSG00000198721.8 | 1.327E-9 | 0 | 14000 | gtex_brain_putamen_basal |
| rs643232 | 6 | 4122249 | ECI2 | ENSG00000198721.8 | 1.327E-9 | 0 | 13582 | gtex_brain_putamen_basal |
| rs659305 | 6 | 4125655 | ECI2 | ENSG00000198721.8 | 1.327E-9 | 0 | 10176 | gtex_brain_putamen_basal |
| rs660560 | 6 | 4125941 | ECI2 | ENSG00000198721.8 | 1.407E-9 | 0 | 9890 | gtex_brain_putamen_basal |
| rs612022 | 6 | 4126916 | ECI2 | ENSG00000198721.8 | 1.885E-9 | 0 | 8915 | gtex_brain_putamen_basal |
| rs676683 | 6 | 4127253 | ECI2 | ENSG00000198721.8 | 2.09E-9 | 0 | 8578 | gtex_brain_putamen_basal |
| rs689308 | 6 | 4127730 | ECI2 | ENSG00000198721.8 | 2.461E-9 | 0 | 8101 | gtex_brain_putamen_basal |
| rs3177253 | 6 | 4133855 | ECI2 | ENSG00000198721.8 | 3.893E-8 | 0 | 1976 | gtex_brain_putamen_basal |
| rs35071107 | 6 | 4135225 | ECI2 | ENSG00000198721.8 | 1.556E-8 | 0 | 606 | gtex_brain_putamen_basal |
| rs45529732 | 6 | 4135262 | ECI2 | ENSG00000198721.8 | 6.763E-9 | 0 | 569 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ASXL1 | 0.92 | 0.93 |
| RAF1 | 0.92 | 0.92 |
| DCLRE1B | 0.92 | 0.90 |
| RSPRY1 | 0.92 | 0.93 |
| KDM4A | 0.92 | 0.93 |
| ZNF828 | 0.92 | 0.94 |
| USP10 | 0.92 | 0.94 |
| NCOA5 | 0.92 | 0.94 |
| ISG20L2 | 0.91 | 0.94 |
| TCEB3 | 0.91 | 0.91 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| S100B | -0.76 | -0.88 |
| AIFM3 | -0.76 | -0.79 |
| HLA-F | -0.76 | -0.80 |
| C5orf53 | -0.75 | -0.77 |
| AF347015.31 | -0.74 | -0.89 |
| FXYD1 | -0.74 | -0.90 |
| MT-CO2 | -0.74 | -0.91 |
| TSC22D4 | -0.74 | -0.81 |
| AF347015.27 | -0.74 | -0.88 |
| AF347015.33 | -0.73 | -0.88 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000062 | acyl-CoA binding | IEA | - | |
| GO:0004165 | dodecenoyl-CoA delta-isomerase activity | IEA | - | |
| GO:0005488 | binding | IEA | - | |
| GO:0016853 | isomerase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0008152 | metabolic process | IEA | - | |
| GO:0006631 | fatty acid metabolic process | TAS | 10419495 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005739 | mitochondrion | IDA | 11256614 | |
| GO:0005777 | peroxisome | TAS | 10419495 | |
| GO:0005782 | peroxisomal matrix | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG FATTY ACID METABOLISM | 42 | 29 | All SZGR 2.0 genes in this pathway |
| KEGG PEROXISOME | 78 | 47 | All SZGR 2.0 genes in this pathway |
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| LIU PROSTATE CANCER UP | 96 | 57 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LIVE DN | 384 | 220 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| AKL HTLV1 INFECTION UP | 27 | 16 | All SZGR 2.0 genes in this pathway |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | 362 | 238 | All SZGR 2.0 genes in this pathway |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP | 204 | 140 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER BASAL VS LULMINAL | 330 | 215 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER CLUSTER 7 | 20 | 11 | All SZGR 2.0 genes in this pathway |
| DAIRKEE TERT TARGETS UP | 380 | 213 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
| PASQUALUCCI LYMPHOMA BY GC STAGE UP | 283 | 177 | All SZGR 2.0 genes in this pathway |
| VANTVEER BREAST CANCER METASTASIS UP | 56 | 31 | All SZGR 2.0 genes in this pathway |
| XU RESPONSE TO TRETINOIN DN | 13 | 8 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY NO BLOOD DN | 150 | 93 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY DN | 145 | 88 | All SZGR 2.0 genes in this pathway |
| XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | All SZGR 2.0 genes in this pathway |
| ZHENG BOUND BY FOXP3 | 491 | 310 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS UP | 388 | 234 | All SZGR 2.0 genes in this pathway |
| LIN MELANOMA COPY NUMBER UP | 73 | 53 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 2D UP | 69 | 46 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS | 535 | 325 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA PCA3 DN | 69 | 38 | All SZGR 2.0 genes in this pathway |
| VANTVEER BREAST CANCER POOR PROGNOSIS | 55 | 30 | All SZGR 2.0 genes in this pathway |
| SUBTIL PROGESTIN TARGETS | 36 | 25 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 2 DN | 336 | 211 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR | 152 | 88 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |
| GUO TARGETS OF IRS1 AND IRS2 | 98 | 67 | All SZGR 2.0 genes in this pathway |