Gene Page: ADARB2

Summary ?
GeneID105
SymbolADARB2
SynonymsADAR3|RED2
Descriptionadenosine deaminase, RNA specific B2 (inactive)
ReferenceMIM:602065|HGNC:HGNC:227|Ensembl:ENSG00000185736|HPRD:09070|Vega:OTTHUMG00000017543
Gene typeprotein-coding
Map location10p15.3
Pascal p-value0.687
Sherlock p-value0.218
DMG2 (# studies)
eGeneCerebellum
Cortex
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 8
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 8

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg13504411101596029ADARB24.19E-50.6370.021DMG:Wockner_2014
cg19163058101595785ADARB24.54E-50.5220.021DMG:Wockner_2014
cg19533322101595704ADARB27.36E-50.5460.025DMG:Wockner_2014
cg20731819101509859ADARB21.043E-40.5390.028DMG:Wockner_2014
cg09265586101595595ADARB23.557E-40.5180.042DMG:Wockner_2014
cg17898884101725190ADARB24.249E-4-0.6030.045DMG:Wockner_2014
cg05289540101595989ADARB25.013E-40.4490.047DMG:Wockner_2014
cg12557867101779033ADARB29.89E-8-0.0072.2E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SUSD50.830.78
SIRPA0.830.80
LRRK10.820.75
PACSIN10.810.75
IQSEC20.800.73
MICAL20.800.76
RASGRF20.800.77
CAMK2A0.800.72
PDE8B0.790.81
PIP5K1B0.790.78
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BCL7C-0.52-0.59
EXOSC8-0.49-0.47
HEBP2-0.49-0.59
SNHG12-0.48-0.52
C9orf46-0.47-0.50
RBMX2-0.47-0.47
C21orf57-0.47-0.50
RPS13P2-0.47-0.50
RPL23A-0.47-0.50
LEMD1-0.45-0.35

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
TANAKA METHYLATED IN ESOPHAGEAL CARCINOMA 10358All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN 185111All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 12683All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3 13785All SZGR 2.0 genes in this pathway
DEMAGALHAES AGING UP 5539All SZGR 2.0 genes in this pathway
DUAN PRDM5 TARGETS 7952All SZGR 2.0 genes in this pathway