SZGR2

Summary ?

GeneID	10768
Symbol	AHCYL1
Synonyms	DCAL\|IRBIT\|PPP1R78\|PRO0233\|XPVKONA
Description	adenosylhomocysteinase like 1
Reference	MIM:607826\|HGNC:HGNC:344\|Ensembl:ENSG00000168710\|HPRD:07613\|Vega:OTTHUMG00000011652
Gene type	protein-coding
Map location	1p13.2
Pascal p-value	0.039
Sherlock p-value	0.53
Support	CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_I	Genome scan meta-analysis	Psr: 0.0235

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SMC4	0.92	0.81
FBXO5	0.91	0.83
PLK4	0.91	0.80
SGOL2	0.90	0.83
KNTC1	0.90	0.81
ERCC6L	0.90	0.74
CHEK1	0.89	0.79
C11orf82	0.89	0.81
FANCI	0.89	0.76
TTK	0.89	0.79

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
HLA-F	-0.55	-0.74
MT-CO2	-0.55	-0.80
AIFM3	-0.54	-0.75
AF347015.33	-0.54	-0.80
AF347015.31	-0.54	-0.78
AF347015.27	-0.54	-0.78
MT-CYB	-0.54	-0.81
SLC9A3R2	-0.53	-0.62
AF347015.15	-0.53	-0.81
TINAGL1	-0.53	-0.74

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003824	catalytic activity	IEA		-
GO:0004013	adenosylhomocysteinase activity	IEA		-
GO:0005488	binding	IEA		-
GO:0016787	hydrolase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008152	metabolic process	IEA		-
GO:0006730	one-carbon compound metabolic process	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005783	endoplasmic reticulum	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CYSTEINE AND METHIONINE METABOLISM	34	24	All SZGR 2.0 genes in this pathway
KEGG SELENOAMINO ACID METABOLISM	26	18	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE UP	108	67	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN	406	230	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP	233	161	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP	164	122	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN	196	131	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC	108	74	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
DORSAM HOXA9 TARGETS UP	35	25	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 UP	89	51	All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS	191	131	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD DN	150	93	All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP	262	186	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP	388	234	All SZGR 2.0 genes in this pathway
NICK RESPONSE TO PROC TREATMENT DN	27	18	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
OKAMOTO LIVER CANCER MULTICENTRIC OCCURRENCE UP	25	15	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS	535	325	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	362	368	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-135	1884	1890	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1884	1890	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-137	2023	2029	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-143	129	136	1A,m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-182	1579	1586	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-24	953	959	1A	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-25/32/92/363/367	2000	2006	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-320	1382	1388	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-33	1998	2004	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	1998	2004	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-496	1888	1894	m8	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-96	1580	1586	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: AHCYL1