Gene Page: SDS

Summary ?
GeneID10993
SymbolSDS
SynonymsSDH
Descriptionserine dehydratase
ReferenceMIM:182128|HGNC:HGNC:10691|Ensembl:ENSG00000135094|HPRD:01633|Vega:OTTHUMG00000169554
Gene typeprotein-coding
Map location12q24.13
Pascal p-value9.755E-5
Fetal beta-1.765
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypalClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17455108chr14724047SDS109930.01trans
rs6703905chr189656748SDS109930.01trans
rs924019chr3184794255SDS109930.07trans
rs17007771chr4124970238SDS109930.01trans
rs17007781chr4124977313SDS109930.03trans
rs1028198chr4124977733SDS109930.02trans
rs226946chr63717139SDS109930.19trans
rs226966chr63720300SDS109930.14trans
rs3803656chr1681551505SDS109930trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SLC25A110.900.90
MRPL380.890.91
TMEM2220.880.88
UQCRC10.880.87
MRPS18B0.880.84
AES0.880.88
PSMD80.880.84
C21orf330.870.85
NIT10.860.83
FBXW50.860.87
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.18-0.60-0.49
MT-ATP8-0.55-0.42
AL139819.3-0.55-0.49
AC010300.1-0.54-0.59
NSBP1-0.54-0.53
AF347015.21-0.53-0.38
AF347015.8-0.53-0.37
AF347015.26-0.52-0.38
AF347015.2-0.52-0.34
MT-CYB-0.49-0.34

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLYCINE SERINE AND THREONINE METABOLISM 3126All SZGR 2.0 genes in this pathway
KEGG CYSTEINE AND METHIONINE METABOLISM 3424All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN 14383All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276165All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341197All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
WENG POR TARGETS LIVER DN 2011All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 11462All SZGR 2.0 genes in this pathway