Gene Page: ADRA1B

Summary ?
GeneID147
SymbolADRA1B
SynonymsADRA1|ALPHA1BAR
Descriptionadrenoceptor alpha 1B
ReferenceMIM:104220|HGNC:HGNC:278|HPRD:00080|
Gene typeprotein-coding
Map location5q33.3
Pascal p-value0.507
Fetal beta-0.89
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
ADT:Sun_2012Systematic Investigation of Antipsychotic Drugs and Their TargetsA total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.0032 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00459 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0483 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MN10.910.89
SOBP0.900.94
MPPED10.890.92
SCUBE10.880.81
SLA0.880.88
TTC280.880.87
SATB20.880.90
NHSL10.870.70
SLC22A230.870.87
MYCN0.870.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SERPINB6-0.60-0.76
ACOT13-0.57-0.67
HEPN1-0.57-0.74
AIFM3-0.57-0.74
HSD17B14-0.57-0.77
C5orf53-0.57-0.72
HLA-F-0.56-0.73
ALDOC-0.56-0.67
CLU-0.56-0.68
TSC22D4-0.56-0.76

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004937alpha1-adrenergic receptor activityTAS1328250 
GO:0004935adrenoceptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001987vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressureIEA-
GO:0001996positive regulation of heart rate by epinephrine-norepinephrineIEA-
GO:0001997positive regulation of the force of heart contraction by epinephrine-norepinephrineIEA-
GO:0001975response to amphetamineIEA-
GO:0001974blood vessel remodelingIEA-
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerTAS10820200 
GO:0007186G-protein coupled receptor protein signaling pathwayTAS2154750 
GO:0016049cell growthIEA-
GO:0007267cell-cell signalingTAS1328250 
GO:0007243protein kinase cascadeTAS10820200 
GO:0007165signal transductionIEA-
GO:0008283cell proliferationTAS10820200 
GO:0008542visual learningIEA-
GO:0007512adult heart developmentIEA-
GO:0007626locomotory behaviorIEA-
GO:0007275multicellular organismal developmentTAS10820200 
GO:0042593glucose homeostasisIEA-
GO:0035265organ growthIEA-
GO:0043278response to morphineIEA-
GO:0048148behavioral response to cocaineIEA-
GO:0045819positive regulation of glycogen catabolic processIEA-
GO:0045818negative regulation of glycogen catabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000299integral to membrane of membrane fractionIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS1328250 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 11581All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 6653All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME AMINE LIGAND BINDING RECEPTORS 3833All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS 7456All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
PETRETTO HEART MASS QTL CIS UP 2815All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 24HR DN 3321All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN WITHOUT MGMT 48HR DN 3225All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS 3632All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161105All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274165All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP 143100All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 14985All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP 221120All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-22141147m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU