Gene Page: TTC9B
Summary ?
| GeneID | 148014 |
| Symbol | TTC9B |
| Synonyms | - |
| Description | tetratricopeptide repeat domain 9B |
| Reference | HGNC:HGNC:26395|Ensembl:ENSG00000174521|HPRD:08329|Vega:OTTHUMG00000182600 |
| Gene type | protein-coding |
| Map location | 19q13.2 |
| Pascal p-value | 0.83 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg14882636 | 19 | 40722039 | TTC9B | 1.471E-4 | 0.449 | 0.031 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17028363 | chr2 | 41913161 | TTC9B | 148014 | 0.16 | trans | ||
| rs16829545 | chr2 | 151977407 | TTC9B | 148014 | 5.266E-11 | trans | ||
| rs7584986 | chr2 | 184111432 | TTC9B | 148014 | 0.06 | trans | ||
| rs10491487 | chr5 | 80323367 | TTC9B | 148014 | 0.03 | trans | ||
| rs16955618 | chr15 | 29937543 | TTC9B | 148014 | 2.282E-8 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ODONNELL TFRC TARGETS DN | 139 | 76 | All SZGR 2.0 genes in this pathway |
| KUUSELO PANCREATIC CANCER 19Q13 AMPLIFICATION | 35 | 22 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 | 491 | 319 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 HCP WITH H3K27ME3 | 435 | 318 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| PEDRIOLI MIR31 TARGETS UP | 221 | 120 | All SZGR 2.0 genes in this pathway |