Gene Page: CYC1

Summary ?
GeneID1537
SymbolCYC1
SynonymsMC3DN6|UQCR4
Descriptioncytochrome c1
ReferenceMIM:123980|HGNC:HGNC:2579|Ensembl:ENSG00000179091|HPRD:00480|Vega:OTTHUMG00000165242
Gene typeprotein-coding
Map location8q24.3
Pascal p-value0.778
Sherlock p-value0.931
Fetal beta-0.642
DMG2 (# studies)
SupportG2Cdb.human_mitochondria
G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 3
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg217655778145150022CYC12.36E-5-0.210.017DMG:Wockner_2014
cg035764258145151285CYC19.88E-50.3010.028DMG:Wockner_2014
cg028683388145133133CYC12.665E-44.917DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C1orf1750.620.68
NTN50.590.60
MALAT10.580.64
UAP1L10.580.62
C15orf520.580.59
RYR10.570.63
CCDC88B0.570.61
C9orf310.570.57
MUC5B0.570.65
PNPLA70.560.55
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
METTL9-0.48-0.58
ASNSD1-0.47-0.52
TSG101-0.47-0.54
ZCCHC10-0.47-0.54
PDCD2-0.46-0.56
C11orf57-0.46-0.56
PAIP1-0.46-0.53
POLB-0.46-0.54
POLR2B-0.46-0.51
TXNL1-0.46-0.55

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG OXIDATIVE PHOSPHORYLATION 13573All SZGR 2.0 genes in this pathway
KEGG CARDIAC MUSCLE CONTRACTION 8051All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169110All SZGR 2.0 genes in this pathway
KEGG PARKINSONS DISEASE 13378All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE 185109All SZGR 2.0 genes in this pathway
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 14185All SZGR 2.0 genes in this pathway
REACTOME MITOCHONDRIAL PROTEIN IMPORT 5824All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
REACTOME RESPIRATORY ELECTRON TRANSPORT 7944All SZGR 2.0 genes in this pathway
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 9856All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368234All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER ADVANCED VS EARLY DN 13870All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430232All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
BARIS THYROID CANCER UP 239All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP 169127All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC 10874All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON 15787All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 14396All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 14591All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP 151100All SZGR 2.0 genes in this pathway
MOOTHA VOXPHOS 8751All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA DN 3929All SZGR 2.0 genes in this pathway
NADLER OBESITY DN 4834All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE DN 8759All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 5 12678All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261183All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 14192All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
WONG MITOCHONDRIA GENE MODULE 217122All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198128All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
MOOTHA PGC 420269All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447277All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298174All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
LI DCP2 BOUND MRNA 8957All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336211All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway