SZGR2

Summary ?

GeneID	1602
Symbol	DACH1
Synonyms	DACH
Description	dachshund family transcription factor 1
Reference	MIM:603803\|HGNC:HGNC:2663\|Ensembl:ENSG00000276644\|HPRD:16031\|Vega:OTTHUMG00000017063
Gene type	protein-coding
Map location	13q22
Pascal p-value	2.563E-4
Sherlock p-value	0.364
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs17542473	chr4	111182451	DACH1	1602		0.18		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003677	DNA binding	IEA		-
GO:0005515	protein binding	IPI		14525983
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
GO:0007275	multicellular organismal development	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
WATANABE COLON CANCER MSI VS MSS DN	81	42	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN	175	82	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP	380	215	All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 UP	112	72	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR UP	85	54	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN	205	127	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN	142	90	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP	380	236	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN DN	172	112	All SZGR 2.0 genes in this pathway
BEGUM TARGETS OF PAX3 FOXO1 FUSION UP	60	45	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL	330	215	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN	164	111	All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN	114	58	All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS UP	201	127	All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 LASER UP	34	25	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS	652	441	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN	103	64	All SZGR 2.0 genes in this pathway
ROSS AML WITH MLL FUSIONS	78	45	All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP	78	56	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN	246	180	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP	280	183	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
CAMPS COLON CANCER COPY NUMBER UP	92	45	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BRAIN DN	85	58	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP	172	109	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING	246	152	All SZGR 2.0 genes in this pathway
ROSS LEUKEMIA WITH MLL FUSIONS	78	49	All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 16	26	17	All SZGR 2.0 genes in this pathway
VALK AML WITH 11Q23 REARRANGED	22	13	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN	134	83	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN	69	48	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION	130	87	All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED	351	238	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN	336	211	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	731	737	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-132/212	2625	2631	1A	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	2625	2631	1A	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-134	966	972	1A	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-138	430	436	1A	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-145	1326	1333	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/497	260	266	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-153	2397	2404	1A,m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-200bc/429	971	978	1A,m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-217	845	852	1A,m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-221/222	1199	1205	m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	1199	1205	m8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-23	2607	2613	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	2607	2613	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-30-3p	1155	1161	1A	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	1155	1161	1A	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-323	2607	2613	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-326	195	201	1A	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-33	2553	2559	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	2553	2559	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-338	263	269	1A	hsa-miR-338^brain	UCCAGCAUCAGUGAUUUUGUUGA
miR-342	2609	2615	1A	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-369-3p	2376	2382	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	2376	2383	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-376	2442	2448	1A	hsa-miR-376a	AUCAUAGAGGAAAAUCCACGU
miR-376	2442	2448	1A	hsa-miR-376b	AUCAUAGAGGAAAAUCCAUGUU
miR-381	1035	1041	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-382	1994	2001	1A,m8	hsa-miR-382^brain	GAAGUUGUUCGUGGUGGAUUCG
miR-384	866	872	1A	hsa-miR-384	AUUCCUAGAAAUUGUUCAUA
miR-410	1721	1727	m8	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-448	2398	2404	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-493-5p	801	807	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
				hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
				hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
				hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-496	947	954	1A,m8	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-505	9	15	1A	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-543	2222	2228	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-7	1637	1643	m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: DACH1