SZGR2

Summary ?

GeneID	1759
Symbol	DNM1
Synonyms	DNM\|EIEE31
Description	dynamin 1
Reference	MIM:602377\|HGNC:HGNC:2972\|Ensembl:ENSG00000106976\|HPRD:03851\|Vega:OTTHUMG00000020733
Gene type	protein-coding
Map location	9q34
Pascal p-value	0.058
Sherlock p-value	0.923
Fetal beta	-2.426
Support	ENDOCYTOSIS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_clathrin G2Cdb.human_mGluR5 G2Cdb.human_Synaptosome G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP Darnell FMRP targets Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.3528

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg14409940	9	130967820	CIZ1;DNM1	2.485E-4	0.432	0.037	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003774	motor activity	IEA		-
GO:0003924	GTPase activity	IEA		-
GO:0003924	GTPase activity	TAS		10944110
GO:0005515	protein binding	ISS		-
GO:0005525	GTP binding	IEA		-
GO:0016787	hydrolase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006898	receptor-mediated endocytosis	TAS		8101525
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005856	cytoskeleton	IEA		-
GO:0005874	microtubule	IEA		-
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AMPH	AMPH1	amphiphysin	Affinity Capture-Western Reconstituted Complex	BioGRID	9148966 \|9280305 \|9341169 \|9348539 \|11877424
AMPH	AMPH1	amphiphysin	-	HPRD	9148966 \|9348539 \|9694653 \|11877424\|10899172
AP2A2	ADTAB \| CLAPA2 \| HIP9 \| HYPJ	adaptor-related protein complex 2, alpha 2 subunit	-	HPRD	10430869
ASB13	FLJ13134 \| MGC19879	ankyrin repeat and SOCS box-containing 13	Two-hybrid	BioGRID	16169070
BIN1	AMPH2 \| AMPHL \| DKFZp547F068 \| MGC10367 \| SH3P9	bridging integrator 1	-	HPRD,BioGRID	9195986 \|9280305
CABIN1	CAIN \| KIAA0330 \| PPP3IN	calcineurin binding protein 1	-	HPRD,BioGRID	10931822
CLIC3	-	chloride intracellular channel 3	-	HPRD	11563969
CLIC4	CLIC4L \| DKFZp566G223 \| FLJ38640 \| H1 \| MTCLIC \| huH1 \| p64H1	chloride intracellular channel 4	-	HPRD	11563969
CLINT1	CLINT \| ENTH \| EPN4 \| EPNR \| EPSINR \| FLJ46753 \| KIAA0171	clathrin interactor 1	Reconstituted Complex	BioGRID	12429846
CTTN	EMS1 \| FLJ34459	cortactin	-	HPRD	12419186
DNM1	DNM	dynamin 1	-	HPRD,BioGRID	7634088
DNMBP	KIAA1010 \| TUBA	dynamin binding protein	-	HPRD,BioGRID	14506234
DYRK1A	DYRK \| DYRK1 \| HP86 \| MNB \| MNBH	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	Reconstituted Complex	BioGRID	11877424
EPS15	AF-1P \| AF1P \| MLLT5	epidermal growth factor receptor pathway substrate 15	-	HPRD	11483962
FER	TYK3	fer (fps/fes related) tyrosine kinase	Co-fractionation	BioGRID	9722593
FNBP1	FBP17 \| KIAA0554 \| MGC126804	formin binding protein 1	-	HPRD,BioGRID	15252009
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	-	HPRD	12359736
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	Affinity Capture-Western Far Western Reconstituted Complex	BioGRID	8119878 \|9009162
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD	8119878 \|11877424
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
GRIN2D	EB11 \| NMDAR2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	-	HPRD	10862698
ITSN1	ITSN \| MGC134948 \| MGC134949 \| SH3D1A \| SH3P17	intersectin 1 (SH3 domain protein)	-	HPRD	10373452
KIAA1377	-	KIAA1377	Two-hybrid	BioGRID	16169070
MAP3K10	MLK2 \| MST	mitogen-activated protein kinase kinase kinase 10	Reconstituted Complex	BioGRID	9742220
MED31	3110004H13Rik \| CGI-125 \| FLJ27436 \| FLJ36714 \| Soh1	mediator complex subunit 31	Two-hybrid	BioGRID	16169070
MOBKL3	2C4D \| CGI-95 \| MGC12264 \| MOB1 \| MOB3 \| PREI3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	-	HPRD	11872741
NCK1	MGC12668 \| NCK \| NCKalpha	NCK adaptor protein 1	-	HPRD,BioGRID	10206341
NCK2	GRB4 \| NCKbeta	NCK adaptor protein 2	-	HPRD	11557983
NME2	MGC111212 \| NDPK-B \| NDPKB \| NM23-H2 \| NM23B \| puf	non-metastatic cells 2, protein (NM23B) expressed in	-	HPRD	11872741
PACSIN1	KIAA1379 \| SDPI	protein kinase C and casein kinase substrate in neurons 1	-	HPRD,BioGRID	11082044
PACSIN1	KIAA1379 \| SDPI	protein kinase C and casein kinase substrate in neurons 1	-	HPRD	9950691 \|11082044
PACSIN2	SDPII	protein kinase C and casein kinase substrate in neurons 2	Reconstituted Complex	BioGRID	11082044
PACSIN3	SDPIII	protein kinase C and casein kinase substrate in neurons 3	-	HPRD,BioGRID	11082044
PFN2	D3S1319E \| PFL	profilin 2	-	HPRD	9463375
PIAS1	DDXBP1 \| GBP \| GU/RH-II \| MGC141878 \| MGC141879 \| ZMIZ3	protein inhibitor of activated STAT, 1	-	HPRD	15123615
PIN4	EPVH \| MGC138486 \| PAR14 \| PAR17	protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)	Two-hybrid	BioGRID	16169070
PRNP	ASCR \| CD230 \| CJD \| GSS \| MGC26679 \| PRIP \| PrP \| PrP27-30 \| PrP33-35C \| PrPc \| prion	prion protein	-	HPRD	15146195
SH3GL1	CNSA1 \| EEN \| MGC111371 \| SH3D2B \| SH3P8	SH3-domain GRB2-like 1	-	HPRD,BioGRID	9238017 \|10764144
SH3GL2	CNSA2 \| EEN-B1 \| FLJ20276 \| FLJ25015 \| SH3D2A \| SH3P4	SH3-domain GRB2-like 2	Reconstituted Complex	BioGRID	9341169 \|12456676
SH3GL2	CNSA2 \| EEN-B1 \| FLJ20276 \| FLJ25015 \| SH3D2A \| SH3P4	SH3-domain GRB2-like 2	-	HPRD	11877424
SH3GL2	CNSA2 \| EEN-B1 \| FLJ20276 \| FLJ25015 \| SH3D2A \| SH3P4	SH3-domain GRB2-like 2	-	HPRD	9238017 \|11877424
SH3GL3	CNSA3 \| EEN-2B-L3 \| EEN-B2 \| HsT19371 \| SH3D2C \| SH3P13	SH3-domain GRB2-like 3	Endophilin A3 interacts with Dynamin.	BIND	11894096
SH3GL3	CNSA3 \| EEN-2B-L3 \| EEN-B2 \| HsT19371 \| SH3D2C \| SH3P13	SH3-domain GRB2-like 3	-	HPRD	9238017
SH3GLB1	Bif-1 \| CGI-61 \| KIAA0491 \| dJ612B15.2	SH3-domain GRB2-like endophilin B1	Reconstituted Complex	BioGRID	12456676
SNAP25	FLJ23079 \| RIC-4 \| RIC4 \| SEC9 \| SNAP \| SNAP-25 \| bA416N4.2 \| dJ1068F16.2	synaptosomal-associated protein, 25kDa	-	HPRD	10373452

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ENDOCYTOSIS	183	132	All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS	97	71	All SZGR 2.0 genes in this pathway
BIOCARTA NDKDYNAMIN PATHWAY	21	15	All SZGR 2.0 genes in this pathway
BIOCARTA GABA PATHWAY	10	10	All SZGR 2.0 genes in this pathway
BIOCARTA BARR MAPK PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA BARRESTIN SRC PATHWAY	15	14	All SZGR 2.0 genes in this pathway
BIOCARTA BARRESTIN PATHWAY	10	8	All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY	59	49	All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY	40	38	All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY	57	43	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY	62	48	All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY	34	26	All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY	41	35	All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY	43	34	All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY	43	32	All SZGR 2.0 genes in this pathway
PID IL8 CXCR1 PATHWAY	28	19	All SZGR 2.0 genes in this pathway
PID EPHRINB REV PATHWAY	30	25	All SZGR 2.0 genes in this pathway
REACTOME GAP JUNCTION DEGRADATION	10	8	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING	129	74	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION	91	61	All SZGR 2.0 genes in this pathway
REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	13	7	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS	86	62	All SZGR 2.0 genes in this pathway
REACTOME RECYCLING PATHWAY OF L1	27	15	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME GAP JUNCTION TRAFFICKING	27	19	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN	536	332	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA REVERSIBLY UP	8	6	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN	378	231	All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP	115	78	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN	234	147	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION DN	84	54	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN	394	258	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK UP	214	144	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN	357	212	All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN	102	67	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM	302	191	All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS DN	40	31	All SZGR 2.0 genes in this pathway
DASU IL6 SIGNALING SCAR UP	30	21	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 7	51	34	All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX DN	54	43	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 9	92	59	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN	209	137	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 11	36	24	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS INTERFERON DN	52	30	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2	491	319	All SZGR 2.0 genes in this pathway
DASU IL6 SIGNALING UP	59	44	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP	430	288	All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE GENES	90	54	All SZGR 2.0 genes in this pathway
BILANGES SERUM RESPONSE TRANSLATION	37	20	All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS UP	163	111	All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF	367	231	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN	146	88	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-224	107	114	1A,m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-224	107	114	1A,m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: DNM1