Gene Page: ABCA1

Summary
GeneID  19
Symbol  ABCA1
Synonyms  ABC-1|ABC1|CERP|FLJ14958|HDLDT1|MGC164864|MGC165011|TGD
Description  ATP-binding cassette, sub-family A (ABC1), member 1
See related  HGNC:29|MIM:600046|Ensembl:ENSG00000165029|HPRD:02501|
Locus tag  -
Gene type  protein-coding
Map location  9q31.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0323 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DHX150.940.91
SF3B10.930.92
ZNF220.930.90
ELP20.930.91
CDKAL10.930.89
METAP20.920.92
C2orf670.920.91
DHX90.920.88
DDX50.920.91
UHRF20.920.89
Top 10 negatively co-expressed genes
AF347015.27-0.70-0.81
MT-CO2-0.69-0.82
AF347015.31-0.69-0.82
IFI27-0.67-0.82
AF347015.33-0.67-0.78
HLA-F-0.67-0.72
AF347015.8-0.67-0.81
MT-CYB-0.67-0.80
AIFM3-0.66-0.72
PTH1R-0.66-0.73
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005543phospholipid bindingIC16702602 
GO:0005548phospholipid transporter activityIDA16702602 
GO:0005515protein bindingIPI16192269 
GO:0005524ATP bindingIEA-
GO:0008509anion transmembrane transporter activityIEA-
GO:0017127cholesterol transporter activityIDA12084722 
GO:0016887ATPase activityIEA-
GO:0015485cholesterol bindingIC12084722 
GO:0031267small GTPase bindingIPI16443932 
GO:0030349syntaxin-13 bindingIPI15469992 
GO:0034188apolipoprotein A-I receptor activityIDA16443932 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0060155platelet dense granule organizationIMPserotonin (GO term level: 7)15163665 
GO:0002790peptide secretionIEA-
GO:0007186G-protein coupled receptor protein signaling pathwayIMP16443932 
GO:0006497protein amino acid lipidationIEA-
GO:0008202steroid metabolic processIEA-
GO:0008203cholesterol metabolic processIEA-
GO:0006810transportIEA-
GO:0007040lysosome organizationIDA15163665 
GO:0006629lipid metabolic processIEA-
GO:0006911phagocytosis, engulfmentIEA-
GO:0016197endosome transportIDA14747463 
GO:0033344cholesterol effluxIEA-
GO:0032367intracellular cholesterol transportIMP10431236 
GO:0030819positive regulation of cAMP biosynthetic processIMP14701824 
GO:0032488Cdc42 protein signal transductionIMP16443932 
GO:0033700phospholipid effluxIDA10431236 |11162594 
GO:0033700phospholipid effluxIMP16702602 
GO:0042632cholesterol homeostasisIDA10431236 
GO:0045332phospholipid translocationIEA-
GO:0050702interleukin-1 beta secretionIMP11855831 
GO:0043691reverse cholesterol transportIEA-
GO:0055091phospholipid homeostasisIMP16702602 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIEA-
GO:0005624membrane fractionIDA10525055 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneIEA-
GO:0045335phagocytic vesicleIDA15469992 
GO:0045121membrane raftIDA15469992 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APOA1MGC117399apolipoprotein A-IReconstituted ComplexBioGRID12084722 
CREBBPCBP | KAT3A | RSTSCREB binding proteinAffinity Capture-WesternBioGRID11864601 
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domain-HPRD,BioGRID12235128 
SNTB2D16S2531E | EST25263 | SNT2B2 | SNT3 | SNTLsyntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)-HPRD,BioGRID12054535 
XPCXP3 | XPCCxeroderma pigmentosum, complementation group CReconstituted Complex
Two-hybrid		BioGRID12505994 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ABC_TRANSPORTERS 4429All SZGR genes in this pathway
PID_RXR_VDR_PATHWAY 2624All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 10472All SZGR genes in this pathway
REACTOME_HDL_MEDIATED_LIPID_TRANSPORT 1512All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 4637All SZGR genes in this pathway
REACTOME_LIPOPROTEIN_METABOLISM 2824All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP 285181All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
SAMOLS_TARGETS_OF_KHSV_MIRNAS_DN 6235All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP 177110All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_DN 6039All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_UP 9564All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP 7841All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP 9760All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_UP 6445All SZGR genes in this pathway
XU_HGF_TARGETS_REPRESSED_BY_AKT1_DN 9558All SZGR genes in this pathway
DAUER_STAT3_TARGETS_UP 4935All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP 283177All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_UP 9062All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS 185114All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
YU_MYC_TARGETS_DN 5538All SZGR genes in this pathway
GERY_CEBP_TARGETS 12690All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
RUAN_RESPONSE_TO_TNF_UP 1210All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BURTON_ADIPOGENESIS_3 10164All SZGR genes in this pathway
RUAN_RESPONSE_TO_TNF_TROGLITAZONE_UP 1711All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
SARTIPY_NORMAL_AT_INSULIN_RESISTANCE_DN 2111All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
HAN_JNK_SINGALING_DN 3927All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
BURTON_ADIPOGENESIS_6 189112All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
JEPSEN_SMRT_TARGETS 3323All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
MATZUK_POST-IMPLANTATION_AND_POST-PARTUM 1413All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_DN 5734All SZGR genes in this pathway
BEIER_GLIOMA_STEM_CELL_UP 3917All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_DN 7247All SZGR genes in this pathway
MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN 6746All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_0 7654All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_EARLY_UP 6644All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_UP 10467All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_UP 217131All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_GROUP2 6038All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP 344215All SZGR genes in this pathway
GOBERT_CORE_OLIGODENDROCYTE_DIFFERENTIATION 4028All SZGR genes in this pathway
SCHMIDT_POR_TARGETS_IN_LIMB_BUD_DN 87All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101268726931Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-124/506185191m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-128259325991Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-130/30131113117m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-142-5p322332301A,m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-144268726931Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-145311531211Ahsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/15231123118m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-17-5p/20/93.mr/106/519.d307930861A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-18313671373m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-1931103116m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-199311431201Ahsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-232552611Ahsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-262272331Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-27259326001A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-324-3p181187m8hsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
miR-331501571A,m8hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-376c32523258m8hsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-381280828141Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-9283328391Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/52030783084m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
miR-96499505m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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