Gene Page: TMEM17
Summary ?
| GeneID | 200728 |
| Symbol | TMEM17 |
| Synonyms | - |
| Description | transmembrane protein 17 |
| Reference | MIM:614950|HGNC:HGNC:26623|Ensembl:ENSG00000186889|HPRD:15528|Vega:OTTHUMG00000129455 |
| Gene type | protein-coding |
| Map location | 2p15 |
| Pascal p-value | 3.805E-4 |
| Sherlock p-value | 0.201 |
| Fetal beta | -1.062 |
| DMG | 2 (# studies) |
| eGene | Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 2 |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg26234543 | 2 | 62732450 | TMEM17 | 3.425E-4 | 0.493 | 0.041 | DMG:Wockner_2014 |
| cg12385425 | 2 | 62733576 | TMEM17 | 2.71E-9 | -0.019 | 1.95E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17115591 | chr14 | 45262026 | TMEM17 | 200728 | 0.06 | trans | ||
| rs2280379 | chr16 | 86024103 | TMEM17 | 200728 | 0.11 | trans | ||
| rs12917789 | chr16 | 86029348 | TMEM17 | 200728 | 0.12 | trans | ||
| rs9306764 | chrX | 22142353 | TMEM17 | 200728 | 0.11 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
| ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN | 103 | 64 | All SZGR 2.0 genes in this pathway |
| MOLENAAR TARGETS OF CCND1 AND CDK4 UP | 67 | 48 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS DN | 414 | 237 | All SZGR 2.0 genes in this pathway |