Gene Page: FGFR2

Summary
GeneID  2263
Symbol  FGFR2
Synonyms  BEK|BFR-1|CD332|CEK3|CFD1|ECT1|FLJ98662|JWS|K-SAM|KGFR|TK14|TK25
Description  fibroblast growth factor receptor 2
See related  HGNC:3689|MIM:176943|Ensembl:ENSG00000066468|HPRD:01492|
Locus tag  -
Gene type  protein-coding
Map location  10q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03487 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005007fibroblast growth factor receptor activityNAS1400433 |1697263 |8676562 
GO:0005515protein bindingIPI10618369 |12591959 |17981115 
GO:0005524ATP bindingIEA-
GO:0004713protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0008201heparin bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIEA-
GO:0006468protein amino acid phosphorylationNAS1697263 
GO:0016049cell growthNAS8676562 
GO:0008543fibroblast growth factor receptor signaling pathwayEXP17133345 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0016021integral to membraneNAS1697263 
GO:0009986cell surfaceIDA12493773 
GO:0005886plasma membraneEXP1697263 |11294897 
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CACNA1DCACH3 | CACN4 | CACNL1A2 | CCHL1A2 | Cav1.3calcium channel, voltage-dependent, L type, alpha 1D subunit-HPRD11292657 
FGF1AFGF | ECGF | ECGF-beta | ECGFA | ECGFB | FGF-alpha | FGFA | GLIO703 | HBGF1fibroblast growth factor 1 (acidic)-HPRD10618369|11069186 
Co-crystal Structure
Reconstituted Complex		BioGRID8576175 |10618369 
|11069186 
FGF10-fibroblast growth factor 10-HPRD,BioGRID9582367 
FGF2BFGF | FGFB | HBGF-2fibroblast growth factor 2 (basic)-HPRD10950949 
FGF5HBGF-5 | Smag-82fibroblast growth factor 5-HPRD11876253 
FGF7HBGF-7 | KGFfibroblast growth factor 7 (keratinocyte growth factor)Reconstituted ComplexBioGRID9582367 
-HPRD7687739 
FGF9GAF | HBFG-9 | MGC119914 | MGC119915fibroblast growth factor 9 (glia-activating factor)-HPRD8576175 
FGFR2BEK | BFR-1 | CD332 | CEK3 | CFD1 | ECT1 | FLJ98662 | JWS | K-SAM | KGFR | TK14 | TK25fibroblast growth factor receptor 2Co-crystal StructureBioGRID11069186 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD7999363 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
PID_FGF_PATHWAY 5537All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 3724All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 1611All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_MUTANTS 4429All SZGR genes in this pathway
REACTOME_FRS2_MEDIATED_CASCADE 3627All SZGR genes in this pathway
REACTOME_PI_3K_CASCADE 5639All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 10074All SZGR genes in this pathway
REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE 5440All SZGR genes in this pathway
REACTOME_SHC_MEDIATED_CASCADE 2819All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_FGFR_LIGAND_BINDING_AND_ACTIVATION 2215All SZGR genes in this pathway
REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION 129All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
REACTOME_PI3K_CASCADE 7151All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN 5135All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP 12073All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
TAKADA_GASTRIC_CANCER_COPY_NUMBER_UP 75All SZGR genes in this pathway
JOHANSSON_GLIOMAGENESIS_BY_PDGFB_DN 2116All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP 271175All SZGR genes in this pathway
STREICHER_LSM1_TARGETS_UP 4434All SZGR genes in this pathway
EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_DN 4831All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
THEODOROU_MAMMARY_TUMORIGENESIS 3124All SZGR genes in this pathway
KHETCHOUMIAN_TRIM24_TARGETS_UP 4738All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_UP 11679All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
SCHAEFFER_SOX9_TARGETS_IN_PROSTATE_DEVELOPMENT_UP 2119All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_NOS_TARGETS 179105All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 160110All SZGR genes in this pathway
GREENBAUM_E2A_TARGETS_UP 3318All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G6 153112All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
MCCABE_HOXC6_TARGETS_DN 2115All SZGR genes in this pathway
MCCABE_HOXC6_TARGETS_CANCER_UP 3123All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_DN 55All SZGR genes in this pathway
BERNARD_PPAPDC1B_TARGETS_DN 5839All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN 7447All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
KANG_AR_TARGETS_UP 1710All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN 10677All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_TARGETS_DN 2416All SZGR genes in this pathway
RAO_BOUND_BY_SALL4 227149All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.19759821A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5069759811Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-125/3515855911Ahsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-153680686m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-2183583641Ahsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-2210381044m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-223145114571Ahsa-miR-223UGUCAGUUUGUCAAAUACCCC
miR-3383793851Ahsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-369-3p4214271Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374421427m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-4104234291Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-4235545611A,m8hsa-miR-423AGCUCGGUCUGAGGCCCCUCAG
miR-49414641470m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-4963893951Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-543148114871Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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