Gene Page: DIS3
Summary ?
| GeneID | 22894 |
| Symbol | DIS3 |
| Synonyms | 2810028N01Rik|EXOSC11|KIAA1008|RRP44|dis3p |
| Description | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease |
| Reference | MIM:607533|HGNC:HGNC:20604|Ensembl:ENSG00000083520|HPRD:06338| |
| Gene type | protein-coding |
| Map location | 13q22.1 |
| Pascal p-value | 0.006 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AC145098.2 | 0.97 | 0.96 |
| RALGDS | 0.95 | 0.93 |
| ANKRD13B | 0.95 | 0.96 |
| KIAA0895L | 0.95 | 0.97 |
| PLXNA3 | 0.95 | 0.94 |
| ZNF446 | 0.95 | 0.93 |
| LMBR1L | 0.94 | 0.93 |
| CCDC120 | 0.94 | 0.95 |
| FGD1 | 0.94 | 0.96 |
| CUL7 | 0.93 | 0.96 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.75 | -0.88 |
| AF347015.27 | -0.75 | -0.88 |
| MT-CO2 | -0.74 | -0.88 |
| AF347015.33 | -0.72 | -0.85 |
| S100B | -0.72 | -0.83 |
| C5orf53 | -0.72 | -0.74 |
| HLA-F | -0.71 | -0.73 |
| MT-CYB | -0.71 | -0.85 |
| AF347015.8 | -0.71 | -0.87 |
| COPZ2 | -0.70 | -0.80 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003723 | RNA binding | IEA | - | |
| GO:0005515 | protein binding | IPI | 15231747 | |
| GO:0004540 | ribonuclease activity | IEA | - | |
| GO:0004527 | exonuclease activity | IEA | - | |
| GO:0016787 | hydrolase activity | IEA | - | |
| GO:0016219 | GDP-dissociation stimulator activity | IDA | 9562621 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006364 | rRNA processing | TAS | 9562621 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0000178 | exosome (RNase complex) | TAS | 9562621 | |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005737 | cytoplasm | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG RNA DEGRADATION | 59 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME DIABETES PATHWAYS | 133 | 91 | All SZGR 2.0 genes in this pathway |
| REACTOME PERK REGULATED GENE EXPRESSION | 29 | 14 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATION OF GENES BY ATF4 | 26 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME UNFOLDED PROTEIN RESPONSE | 80 | 51 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF MRNA | 284 | 128 | All SZGR 2.0 genes in this pathway |
| REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | 11 | 5 | All SZGR 2.0 genes in this pathway |
| REACTOME DEADENYLATION DEPENDENT MRNA DECAY | 48 | 29 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF RNA | 330 | 155 | All SZGR 2.0 genes in this pathway |
| REACTOME DESTABILIZATION OF MRNA BY BRF1 | 17 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 84 | 50 | All SZGR 2.0 genes in this pathway |
| REACTOME DESTABILIZATION OF MRNA BY KSRP | 17 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | 17 | 7 | All SZGR 2.0 genes in this pathway |
| LIU SOX4 TARGETS DN | 309 | 191 | All SZGR 2.0 genes in this pathway |
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
| OSMAN BLADDER CANCER DN | 406 | 230 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 6HR DN | 514 | 330 | All SZGR 2.0 genes in this pathway |
| BENPORATH CYCLING GENES | 648 | 385 | All SZGR 2.0 genes in this pathway |
| BROWN MYELOID CELL DEVELOPMENT DN | 129 | 86 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 10HR UP | 101 | 69 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RESPONSE TO TRABECTEDIN DN | 271 | 175 | All SZGR 2.0 genes in this pathway |
| KYNG DNA DAMAGE BY GAMMA AND UV RADIATION | 88 | 65 | All SZGR 2.0 genes in this pathway |
| KYNG DNA DAMAGE UP | 226 | 164 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 36HR DN | 185 | 116 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 60HR DN | 277 | 166 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS DN | 89 | 50 | All SZGR 2.0 genes in this pathway |
| WHITFIELD CELL CYCLE G1 S | 147 | 76 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS DN | 553 | 343 | All SZGR 2.0 genes in this pathway |