Gene Page: SIRT2
Summary ?
| GeneID | 22933 |
| Symbol | SIRT2 |
| Synonyms | SIR2|SIR2L|SIR2L2 |
| Description | sirtuin 2 |
| Reference | MIM:604480|HGNC:HGNC:10886|Ensembl:ENSG00000068903|HPRD:10377|Vega:OTTHUMG00000150480 |
| Gene type | protein-coding |
| Map location | 19q13 |
| Pascal p-value | 0.003 |
| Sherlock p-value | 0.792 |
| eGene | Cerebellar Hemisphere Cerebellum Myers' cis & trans Meta |
| Support | INTRACELLULAR SIGNAL TRANSDUCTION |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6448932 | chr4 | 12595798 | SIRT2 | 22933 | 0.18 | trans | ||
| rs5003961 | chr7 | 78072443 | SIRT2 | 22933 | 0.16 | trans | ||
| rs4515471 | chr7 | 78072585 | SIRT2 | 22933 | 0.16 | trans | ||
| rs10259327 | chr7 | 78074924 | SIRT2 | 22933 | 0.16 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SRC | 0.95 | 0.93 |
| ZNF250 | 0.95 | 0.92 |
| LDB1 | 0.94 | 0.94 |
| MTA2 | 0.94 | 0.94 |
| PHF2 | 0.94 | 0.92 |
| BRD1 | 0.94 | 0.95 |
| PATZ1 | 0.94 | 0.90 |
| MORC2 | 0.94 | 0.93 |
| CSNK1E | 0.93 | 0.93 |
| MYD88 | 0.93 | 0.80 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C5orf53 | -0.72 | -0.78 |
| AF347015.31 | -0.70 | -0.90 |
| AF347015.27 | -0.69 | -0.89 |
| AIFM3 | -0.69 | -0.75 |
| HLA-F | -0.69 | -0.74 |
| MT-CO2 | -0.68 | -0.90 |
| ALDOC | -0.68 | -0.69 |
| PTH1R | -0.68 | -0.72 |
| S100B | -0.68 | -0.82 |
| AF347015.33 | -0.67 | -0.85 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CDC14B | CDC14B3 | Cdc14B1 | Cdc14B2 | hCDC14B | CDC14 cell division cycle 14 homolog B (S. cerevisiae) | - | HPRD | 12697818 |
| ELL | C19orf17 | DKFZp434I1916 | ELL1 | Men | elongation factor RNA polymerase II | Affinity Capture-MS | BioGRID | 17353931 |
| GYS1 | GSY | GYS | glycogen synthase 1 (muscle) | Affinity Capture-MS | BioGRID | 17353931 |
| HDAC6 | FLJ16239 | HD6 | JM21 | histone deacetylase 6 | - | HPRD | 12620231 |
| KAT2A | GCN5 | GCN5L2 | MGC102791 | PCAF-b | hGCN5 | K(lysine) acetyltransferase 2A | - | HPRD | 12887892 |
| KRT78 | K5B | Kb40 | keratin 78 | Affinity Capture-MS | BioGRID | 17353931 |
| PHB2 | BAP | BCAP37 | Bap37 | MGC117268 | PNAS-141 | REA | p22 | prohibitin 2 | Affinity Capture-MS | BioGRID | 17353931 |
| RTN4 | ASY | NI220/250 | NOGO | NOGO-A | NOGOC | NSP | NSP-CL | Nbla00271 | Nbla10545 | Nogo-B | Nogo-C | RTN-X | RTN4-A | RTN4-B1 | RTN4-B2 | RTN4-C | reticulon 4 | Affinity Capture-MS | BioGRID | 17353931 |
| SARS | FLJ36399 | SERRS | SERS | seryl-tRNA synthetase | Affinity Capture-MS | BioGRID | 17353931 |
| SP140 | LYSP100 | LYSP100-A | LYSP100-B | MGC126440 | SP140 nuclear body protein | - | HPRD | 12887892 |
| SPOP | TEF2 | speckle-type POZ protein | Affinity Capture-MS | BioGRID | 17353931 |
| TUBB | M40 | MGC117247 | MGC16435 | OK/SW-cl.56 | TUBB1 | TUBB5 | tubulin, beta | Biochemical Activity | BioGRID | 12620231 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID HDAC CLASSIII PATHWAY | 25 | 20 | All SZGR 2.0 genes in this pathway |
| PID HDAC CLASSI PATHWAY | 66 | 50 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | 329 | 196 | All SZGR 2.0 genes in this pathway |
| BERENJENO TRANSFORMED BY RHOA DN | 394 | 258 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| LE EGR2 TARGETS DN | 108 | 84 | All SZGR 2.0 genes in this pathway |
| PEART HDAC PROLIFERATION CLUSTER UP | 57 | 35 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
| REN ALVEOLAR RHABDOMYOSARCOMA UP | 98 | 64 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| BURTON ADIPOGENESIS 9 | 92 | 59 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |