Gene Page: FLT1

Summary ?
GeneID2321
SymbolFLT1
SynonymsFLT|FLT-1|VEGFR-1|VEGFR1
Descriptionfms related tyrosine kinase 1
ReferenceMIM:165070|HGNC:HGNC:3763|Ensembl:ENSG00000102755|HPRD:01297|Vega:OTTHUMG00000016648
Gene typeprotein-coding
Map location13q12
Pascal p-value0.131
Fetal beta-0.723
DMG1 (# studies)
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg142837831329069941FLT16.62E-5-0.5060.024DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
KDRCD309 | FLK1 | VEGFR | VEGFR2kinase insert domain receptor (a type III receptor tyrosine kinase)-HPRD10865839 
KDRCD309 | FLK1 | VEGFR | VEGFR2kinase insert domain receptor (a type III receptor tyrosine kinase)Biochemical ActivityBioGRID12796773 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1Flt-1 interacts with Nck.BIND9600074 
PGFD12S1900 | PGFL | PLGF | PlGF-2 | SHGC-10760placental growth factor-HPRD,BioGRID9452434 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Flt-1 interacts with p85.BIND7657594 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1Reconstituted Complex
Two-hybrid		BioGRID9398617 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1Flt-1 interacts with the amino terminal SH2 domain of PLC-gamma.BIND9398617 
PLCG2-phospholipase C, gamma 2 (phosphatidylinositol-specific)-HPRD9398617 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11Flt-1 interacts with the amino terminal SH2 domain of SHP-2.BIND9600074 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID10749680 
SHC2SCK | SHCB | SLISHC (Src homology 2 domain containing) transforming protein 2Two-hybridBioGRID10749680 
VEGFAMGC70609 | VEGF | VEGF-A | VPFvascular endothelial growth factor AVEGF165 interacts with Flt-1. This interaction was modeled on a demonstrated interaction between human VEGF165 and Flt-1 from an unspecified species.BIND14600159 
VEGFAMGC70609 | VEGF | VEGF-A | VPFvascular endothelial growth factor AVEGF-A interacts with VEGFR-1. This interaction was modeled on a demonstrated interaction between human VEGF-A and VEGFR-1 from an unspecified species.BIND12810700 
VEGFAMGC70609 | VEGF | VEGF-A | VPFvascular endothelial growth factor A-HPRD8621427 
VEGFBVEGFL | VRFvascular endothelial growth factor B-HPRD,BioGRID9751730 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
BIOCARTA NO1 PATHWAY 3324All SZGR 2.0 genes in this pathway
BIOCARTA VEGF PATHWAY 2918All SZGR 2.0 genes in this pathway
PID GLYPICAN 1PATHWAY 2720All SZGR 2.0 genes in this pathway
PID HIF2PATHWAY 3429All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY 2924All SZGR 2.0 genes in this pathway
PID VEGF VEGFR PATHWAY 106All SZGR 2.0 genes in this pathway
PID VEGFR1 PATHWAY 2623All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 6957All SZGR 2.0 genes in this pathway
REACTOME VEGF LIGAND RECEPTOR INTERACTIONS 106All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP 14686All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306188All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A UP 191128All SZGR 2.0 genes in this pathway
CALVET IRINOTECAN SENSITIVE VS RESISTANT UP 55All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
MANTOVANI NFKB TARGETS UP 4333All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING UP 8654All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER METASTASIS DN 12165All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE UP 7958All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD DN 162102All SZGR 2.0 genes in this pathway
JAIN NFKB SIGNALING 7544All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214133All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA 8164All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 8858All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS 3632All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP 8152All SZGR 2.0 genes in this pathway
SU PLACENTA 3018All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 12081All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439257All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246152All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216143All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS DN 9753All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242168All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 142103All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 13087All SZGR 2.0 genes in this pathway
FONTAINE THYROID TUMOR UNCERTAIN MALIGNANCY UP 3623All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER POOR PROGNOSIS 5530All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210148All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199143All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR UP 3325All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway