Gene Page: ORC6L

Summary
GeneID  23594
Symbol  ORC6L
Synonyms  ORC6
Description  origin recognition complex, subunit 6 like (yeast)
See related  HGNC:17151|MIM:607213|Ensembl:ENSG00000091651|HPRD:06237|
Locus tag  -
Gene type  protein-coding
Map location  16q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0005515protein bindingIPI15232106 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006260DNA replicationEXP12791985 
GO:0006260DNA replicationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP10436018 |11095689 |11125146 
|11931757 |12045100 
|15226314 |15684404 
|15707391 
GO:0005664nuclear origin of replication recognition complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC45LCDC45 | CDC45L2 | PORC-PI-1CDC45 cell division cycle 45-like (S. cerevisiae)Two-hybridBioGRID12614612 
CDC7CDC7L1 | HsCDC7 | Hsk1 | MGC117361 | MGC126237 | MGC126238 | huCDC7cell division cycle 7 homolog (S. cerevisiae)-HPRD,BioGRID12614612 
-HPRD12614612 |15232106 
DBF4ASK | CHIF | DBF4A | ZDBF1DBF4 homolog (S. cerevisiae)Affinity Capture-Western
Two-hybrid		BioGRID12614612 
MCM4CDC21 | CDC54 | MGC33310 | P1-CDC21 | hCdc21minichromosome maintenance complex component 4Two-hybridBioGRID12614612 
MCM5CDC46 | MGC5315 | P1-CDC46minichromosome maintenance complex component 5Two-hybridBioGRID12614612 
ORC2LORC2origin recognition complex, subunit 2-like (yeast)-HPRD,BioGRID11323433 
ORC3LLAT | LATHEO | ORC3origin recognition complex, subunit 3-like (yeast)-HPRD,BioGRID11323433 
ORC4LORC4 | ORC4Porigin recognition complex, subunit 4-like (yeast)Affinity Capture-Western
Two-hybrid		BioGRID12614612 
ORC5LORC5 | ORC5P | ORC5Torigin recognition complex, subunit 5-like (yeast)Two-hybridBioGRID12614612 
RPA1HSSB | REPA1 | RF-A | RP-A | RPA70replication protein A1, 70kDaTwo-hybridBioGRID12614612 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
BIOCARTA_MCM_PATHWAY 188All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 3116All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 6737All SZGR genes in this pathway
REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION 105All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_CELL_CYCLE_CHECKPOINTS 12470All SZGR genes in this pathway
REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX 115All SZGR genes in this pathway
REACTOME_M_G1_TRANSITION 8145All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX 5631All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_DNA 9253All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 6536All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 3517All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 3818All SZGR genes in this pathway
REACTOME_G2_M_CHECKPOINTS 4523All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP 13983All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_DN 228137All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_UP 6344All SZGR genes in this pathway
ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_DN 2619All SZGR genes in this pathway
FURUKAWA_DUSP6_TARGETS_PCI35_DN 7440All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
KAUFFMANN_MELANOMA_RELAPSE_UP 6125All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP 176115All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES 14787All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_METASTASIS_DN 12165All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP 180114All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP 178108All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_POOR_PROGNOSIS 5530All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP 221135All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway


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