SZGR2

Summary ?

GeneID	23607
Symbol	CD2AP
Synonyms	CMS
Description	CD2-associated protein
Reference	MIM:604241\|HGNC:HGNC:14258\|Ensembl:ENSG00000198087\|HPRD:05026\|Vega:OTTHUMG00000014799
Gene type	protein-coding
Map location	6p12
Pascal p-value	0.416
Fetal beta	1.339
DMG	1 (# studies)
eGene	Cerebellum

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.04433
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg21434440	6	47446198	CD2AP	1.31E-8	-0.024	5.25E-6	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		12029088 \|14679214
GO:0005200	structural constituent of cytoskeleton	TAS		10339567
GO:0017124	SH3 domain binding	IDA		10339567
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006461	protein complex assembly	TAS		10339567
GO:0007165	signal transduction	NAS		10339567
GO:0007049	cell cycle	IEA		-
GO:0007067	mitosis	IEA		-
GO:0006930	substrate-bound cell migration, cell extension	TAS		10339567
GO:0051301	cell division	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001726	ruffle	IDA		10339567
GO:0005730	nucleolus	IDA		18029348
GO:0005737	cytoplasm	TAS		10339567
GO:0005886	plasma membrane	IDA		18029348
GO:0015629	actin cytoskeleton	TAS		10339567
GO:0031941	filamentous actin	IDA		10339567

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	-	HPRD,BioGRID	10339567
CAPZA1	CAPPA1 \| CAPZ \| CAZ1	capping protein (actin filament) muscle Z-line, alpha 1	-	HPRD,BioGRID	12690097
CASK	CAGH39 \| CMG \| FLJ22219 \| FLJ31914 \| LIN2 \| MICPCH \| TNRC8	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	Reconstituted Complex	BioGRID	15331416
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	CMS interacts with Cbl. This interaction was modeled on a demonstrated interaction between CMS from an unspecified species and human Cbl.	BIND	15128873
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD,BioGRID	11067845
CD2	SRBC \| T11	CD2 molecule	Reconstituted Complex	BioGRID	12690097
CD2	SRBC \| T11	CD2 molecule	-	HPRD	9741631
CD2AP	CMS \| DKFZp586H0519	CD2-associated protein	-	HPRD,BioGRID	10339567
CDH3	CDHP \| HJMD \| PCAD	cadherin 3, type 1, P-cadherin (placental)	Affinity Capture-Western	BioGRID	15331416
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD	10339567
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD	10339567
NPHS1	CNF \| NPHN	nephrosis 1, congenital, Finnish type (nephrin)	-	HPRD,BioGRID	10997929
NPHS2	PDCN \| SRN1	nephrosis 2, idiopathic, steroid-resistant (podocin)	-	HPRD,BioGRID	11733557
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	10339567
PKD2	APKD2 \| MGC138466 \| MGC138468 \| PC2 \| PKD4	polycystic kidney disease 2 (autosomal dominant)	-	HPRD	10913159
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	Affinity Capture-Western	BioGRID	15128873
RAB4A	HRES-1/RAB4 \| RAB4	RAB4A, member RAS oncogene family	-	HPRD,BioGRID	12559036
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	10339567
YES1	HsT441 \| P61-YES \| Yes \| c-yes	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	-	HPRD	10339567

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID NEPHRIN NEPH1 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
PID VEGFR1 PATHWAY	26	23	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION	120	77	All SZGR 2.0 genes in this pathway
REACTOME NEPHRIN INTERACTIONS	20	15	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN	463	290	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
BOGNI TREATMENT RELATED MYELOID LEUKEMIA DN	33	19	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA PROGRESSION RISK	74	44	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS DN	24	17	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 UP	182	119	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D9	28	15	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP	314	201	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP	180	125	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP	178	111	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN	314	188	All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN	92	64	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN	216	143	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN	315	201	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP	408	276	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED	351	238	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN	207	139	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL	216	130	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	2784	2791	1A,m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-128	2486	2492	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	2486	2492	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-137	2642	2648	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-15/16/195/424/497	2698	2705	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-181	2290	2297	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	2275	2282	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-182	2275	2282	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-219	2584	2591	1A,m8	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-221/222	2639	2645	1A	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	2639	2645	1A	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-25/32/92/363/367	2659	2665	m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-26	2560	2566	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	2560	2566	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	2486	2492	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	2486	2492	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-369-3p	308	314	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-409-3p	2783	2789	m8	hsa-miR-409-3p	CGAAUGUUGCUCGGUGAACCCCU
miR-410	156	162	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-452	222	229	1A,m8	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC
miR-485-3p	2568	2574	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-503	2699	2705	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-96	2276	2282	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CD2AP