Gene Page: FKBP8

Summary ?
GeneID23770
SymbolFKBP8
SynonymsFKBP38|FKBPr38
DescriptionFK506 binding protein 8
ReferenceMIM:604840|HGNC:HGNC:3724|Ensembl:ENSG00000105701|HPRD:05327|Vega:OTTHUMG00000183368
Gene typeprotein-coding
Map location19p12
Pascal p-value0.06
Sherlock p-value0.025
Fetal beta-0.719
eGeneMyers' cis & trans
SupportCompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0265 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17204260chr1867195940FKBP8237700.09trans
rs17204309chr1867196019FKBP8237700.09trans
rs17204373chr1867196110FKBP8237700.13trans
rs17204401chr1867196217FKBP8237700.09trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003755peptidyl-prolyl cis-trans isomerase activityIEA-
GO:0005488bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0016853isomerase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001708cell fate specificationIEA-
GO:0006457protein foldingIEA-
GO:0007242intracellular signaling cascadeTAS10197430 
GO:0007224smoothened signaling pathwayIEA-
GO:0009953dorsal/ventral pattern formationIEA-
GO:0006915apoptosisIEA-
GO:0043010camera-type eye developmentIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005739mitochondrionIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0030176integral to endoplasmic reticulum membraneIEA-
GO:0031966mitochondrial membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID NFAT 3PATHWAY 5447All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP 10866All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203130All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRACX DN 2014All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM UP 3830All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
KIM GASTRIC CANCER CHEMOSENSITIVITY 10364All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN 178121All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS 8555All SZGR 2.0 genes in this pathway
NIELSEN GIST 9866All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway