Gene Page: PRR18
Summary ?
| GeneID | 285800 |
| Symbol | PRR18 |
| Synonyms | - |
| Description | proline rich 18 |
| Reference | HGNC:HGNC:28574|Ensembl:ENSG00000176381|HPRD:17533|Vega:OTTHUMG00000167034 |
| Gene type | protein-coding |
| Map location | 6q27 |
| Pascal p-value | 0.25 |
| Sherlock p-value | 0.619 |
| DEG p-value | DEG:Zhao_2015:p=3.70e-04:q=0.0924 |
| Fetal beta | -2.573 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DEG:Zhao_2015 | RNA Sequencing analysis | Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder. |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs651185 | chr1 | 233871029 | PRR18 | 285800 | 0.08 | trans | ||
| rs10229042 | chr7 | 11228259 | PRR18 | 285800 | 0.13 | trans | ||
| rs5003961 | chr7 | 78072443 | PRR18 | 285800 | 0.06 | trans | ||
| rs4515471 | chr7 | 78072585 | PRR18 | 285800 | 0.06 | trans | ||
| rs10259327 | chr7 | 78074924 | PRR18 | 285800 | 0.06 | trans | ||
| rs1844541 | chr10 | 106516231 | PRR18 | 285800 | 0.18 | trans | ||
| rs17137051 | chr16 | 4521748 | PRR18 | 285800 | 0.08 | trans | ||
| rs6632306 | chrX | 35590460 | PRR18 | 285800 | 0.05 | trans | ||
| rs1935404 | chrX | 35605181 | PRR18 | 285800 | 0.08 | trans | ||
| rs5942141 | chrX | 91433860 | PRR18 | 285800 | 0.09 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SENGUPTA NASOPHARYNGEAL CARCINOMA DN | 349 | 157 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 2 UP | 54 | 31 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 UP | 170 | 97 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 7 UP | 118 | 68 | All SZGR 2.0 genes in this pathway |