Gene Page: GTF3C1

Summary ?
GeneID2975
SymbolGTF3C1
SynonymsTFIIIC|TFIIIC220|TFIIICalpha
Descriptiongeneral transcription factor IIIC subunit 1
ReferenceMIM:603246|HGNC:HGNC:4664|Ensembl:ENSG00000077235|HPRD:07540|Vega:OTTHUMG00000176805
Gene typeprotein-coding
Map location16p12
Pascal p-value0.025
Sherlock p-value0.435
eGeneCerebellum
SupportCompositeSet
Darnell FMRP targets
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HIGD1A0.860.86
CD590.850.84
GSTO10.830.83
IFIT10.830.85
NDUFA40.820.81
CTBS0.810.77
HERC60.810.83
TMEM220.810.87
C1orf570.800.66
HOPX0.800.78
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KIAA1949-0.53-0.68
VAV2-0.52-0.65
AXIN1-0.52-0.62
UPF3A-0.51-0.70
SH3BP2-0.51-0.74
ZNF311-0.51-0.63
MARCKSL1-0.51-0.64
VASH1-0.51-0.64
RTF1-0.51-0.61
GMIP-0.51-0.55

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIC17409385 
GO:0003709RNA polymerase III transcription factor activityIC17409385 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042797tRNA transcription from RNA polymerase III promoterIC17409385 
GO:00427915S class rRNA transcriptionIC17409385 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000127transcription factor TFIIIC complexIDA17409385 
GO:0005634nucleusIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKTIPFT1 | FTSAKT interacting proteinTwo-hybridBioGRID16169070 
ASCC2ASC1p100activating signal cointegrator 1 complex subunit 2Two-hybridBioGRID16169070 
C8orf30AFLJ40907chromosome 8 open reading frame 30ATwo-hybridBioGRID16169070 
CHN1ARHGAP2 | CHN | DURS2 | RHOGAP2chimerin (chimaerin) 1Two-hybridBioGRID16169070 
CPE-carboxypeptidase ETwo-hybridBioGRID16169070 
EZH2ENX-1 | EZH1 | KMT6 | MGC9169enhancer of zeste homolog 2 (Drosophila)Two-hybridBioGRID16169070 
FGFR3ACH | CD333 | CEK2 | HSFGFR3EX | JTK4fibroblast growth factor receptor 3Two-hybridBioGRID16169070 
GTF3C4FLJ21002 | KAT12 | MGC138450 | TFIII90 | TFIIIC90 | TFIIICdelta | TFiiiC2-90general transcription factor IIIC, polypeptide 4, 90kDa-HPRD,BioGRID10523658 
IGFBP3BP-53 | IBP3insulin-like growth factor binding protein 3Two-hybridBioGRID16169070 
KLF6BCD1 | COPEB | CPBP | DKFZp686N0199 | GBF | PAC1 | ST12 | ZF9Kruppel-like factor 6Two-hybridBioGRID16169070 
MAPK10FLJ12099 | FLJ33785 | JNK3 | JNK3A | MGC50974 | PRKM10 | p493F12 | p54bSAPKmitogen-activated protein kinase 10Two-hybridBioGRID16169070 
NHP2L115.5K | FA-1 | FA1 | NHPX | OTK27 | SNU13 | SPAG12 | SSFA1NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)Two-hybridBioGRID16169070 
POLR3CRPC3 | RPC62polymerase (RNA) III (DNA directed) polypeptide C (62kD)Affinity Capture-WesternBioGRID10373544 
PRPF38AFLJ14936 | MGC3320 | RP5-965L7.1PRP38 pre-mRNA processing factor 38 (yeast) domain containing ATwo-hybridBioGRID16169070 
RBM23CAPERbeta | FLJ10482 | MGC4458 | PP239 | RNPC4RNA binding motif protein 23Two-hybridBioGRID16169070 
TBC1D17FLJ12168TBC1 domain family, member 17Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380215All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL DN 10166All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION DN 4831All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 LASER UP 3425All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
MANTOVANI NFKB TARGETS UP 4333All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING UP 8654All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 UP 5130All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA PROGNOSIS UP 4730All SZGR 2.0 genes in this pathway
KLEIN PRIMARY EFFUSION LYMPHOMA UP 5129All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245154All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482296All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS 217138All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668419All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN 14690All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP 17097All SZGR 2.0 genes in this pathway