Gene Page: HOOK2
Summary ?
| GeneID | 29911 |
| Symbol | HOOK2 |
| Synonyms | HK2 |
| Description | hook microtubule-tethering protein 2 |
| Reference | MIM:607824|HGNC:HGNC:19885|Ensembl:ENSG00000095066|HPRD:09698|Vega:OTTHUMG00000180372 |
| Gene type | protein-coding |
| Map location | 19p13.2 |
| Pascal p-value | 0.001 |
| Sherlock p-value | 0.297 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ABLIM1 | ABLIM | DKFZp781D0148 | FLJ14564 | KIAA0059 | LIMAB1 | LIMATIN | MGC1224 | actin binding LIM protein 1 | Two-hybrid | BioGRID | 16189514 |
| AKTIP | FT1 | FTS | AKT interacting protein | Two-hybrid | BioGRID | 16189514 |
| APEX2 | APE2 | APEXL2 | XTH2 | APEX nuclease (apurinic/apyrimidinic endonuclease) 2 | Two-hybrid | BioGRID | 16189514 |
| CCDC33 | FLJ23168 | FLJ32855 | MGC34145 | coiled-coil domain containing 33 | Affinity Capture-Western Two-hybrid | BioGRID | 16189514 |
| EPS8 | - | epidermal growth factor receptor pathway substrate 8 | Two-hybrid | BioGRID | 16189514 |
| FAM107A | DRR1 | FLJ30158 | FLJ45473 | TU3A | family with sequence similarity 107, member A | Two-hybrid | BioGRID | 16189514 |
| KIAA0408 | FLJ43995 | RP3-403A15.2 | KIAA0408 | Two-hybrid | BioGRID | 16189514 |
| MCM10 | CNA43 | DNA43 | MGC126776 | PRO2249 | minichromosome maintenance complex component 10 | Two-hybrid | BioGRID | 16189514 |
| MYST2 | HBO1 | HBOA | KAT7 | MYST histone acetyltransferase 2 | Two-hybrid | BioGRID | 16189514 |
| PSMF1 | PI31 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | Two-hybrid | BioGRID | 16189514 |
| RALBP1 | RIP1 | RLIP1 | RLIP76 | ralA binding protein 1 | Two-hybrid | BioGRID | 16189514 |
| RIBC2 | C22orf11 | RIB43A domain with coiled-coils 2 | Two-hybrid | BioGRID | 16189514 |
| USP2 | UBP41 | USP9 | ubiquitin specific peptidase 2 | Two-hybrid | BioGRID | 16189514 |
| UTP14A | KIAA0266 | NY-CO-16 | SDCCAG16 | dJ537K23.3 | UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) | Two-hybrid | BioGRID | 16189514 |
| ZNF250 | FLJ57354 | MGC111123 | MGC9718 | ZFP647 | ZNF647 | zinc finger protein 250 | Two-hybrid | BioGRID | 16189514 |
| ZNF638 | DKFZp686P1231 | MGC26130 | MGC90196 | NP220 | ZFML | Zfp638 | zinc finger protein 638 | Two-hybrid | BioGRID | 16189514 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP | 450 | 256 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER BASAL VS MESENCHYMAL UP | 121 | 45 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS DN | 352 | 225 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 SIGNATURE 3 DN | 162 | 116 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| ONDER CDH1 TARGETS 2 DN | 464 | 276 | All SZGR 2.0 genes in this pathway |
| JIANG HYPOXIA NORMAL | 311 | 205 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS DN | 543 | 317 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS DN | 593 | 372 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS DN | 591 | 366 | All SZGR 2.0 genes in this pathway |
| BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING | 510 | 309 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A5 | 70 | 32 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G1 UP | 113 | 70 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| DELACROIX RARG BOUND MEF | 367 | 231 | All SZGR 2.0 genes in this pathway |
| ZWANG EGF PERSISTENTLY DN | 61 | 36 | All SZGR 2.0 genes in this pathway |