Gene Page: HARS

Summary
GeneID  3035
Symbol  HARS
Synonyms  FLJ20491|HRS
Description  histidyl-tRNA synthetase
See related  HGNC:4816|MIM:142810|Ensembl:ENSG00000170445|HPRD:00827|
Locus tag  -
Gene type  protein-coding
Map location  5q31.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MAT2B0.870.87
IDH3A0.870.86
PPP3R10.870.87
GHITM0.870.87
ARL8B0.870.89
NKIRAS10.870.87
PCMT10.870.86
NAPG0.870.87
CCNY0.870.87
TSNAX0.860.87
Top 10 negatively co-expressed genes
AF347015.18-0.48-0.30
AC010300.1-0.47-0.46
MYLK2-0.43-0.40
AC100783.1-0.42-0.37
AC098691.2-0.40-0.33
C10orf108-0.40-0.41
AF347015.21-0.39-0.20
AL022328.1-0.39-0.43
AF347015.26-0.39-0.21
EGFL8-0.39-0.37
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingNAS-
GO:0004821histidine-tRNA ligase activityNAS1549469 |7755634 
GO:0016874ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006427histidyl-tRNA aminoacylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmNAS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EEF1B2EEF1B | EEF1B1 | EF1Beukaryotic translation elongation factor 1 beta 2Affinity Capture-Western
Reconstituted Complex		BioGRID11829477 
HRS interacts with EF-1-beta.BIND11829477 
EEF1GEF1G | GIG35eukaryotic translation elongation factor 1 gammaHRS interacts with EF-1-gamma.BIND11829477 
-HPRD,BioGRID11829477 
RPL5MGC117339 | MSTP030ribosomal protein L5-HPRD,BioGRID8049265 
TARSMGC9344 | ThrRSthreonyl-tRNA synthetase-HPRD,BioGRID8049265 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 4133All SZGR genes in this pathway
REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 2419All SZGR genes in this pathway
REACTOME_TRNA_AMINOACYLATION 4234All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
CEBALLOS_TARGETS_OF_TP53_AND_MYC_UP 2116All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_CIS 12877All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_CIS 6538All SZGR genes in this pathway
WANG_TARGETS_OF_MLL_CBP_FUSION_DN 4531All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C0 10772All SZGR genes in this pathway
JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_UP 4928All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP 425253All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_DN 10367All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway


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