Gene Page: HSD3B1

Summary ?
GeneID3283
SymbolHSD3B1
Synonyms3BETAHSD|HSD3B|HSDB3|HSDB3A|I|SDR11E1
Descriptionhydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
ReferenceMIM:109715|HGNC:HGNC:5217|Ensembl:ENSG00000203857|HPRD:04920|Vega:OTTHUMG00000012525
Gene typeprotein-coding
Map location1p13.1
Pascal p-value0.314
Fetal beta-0.034

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.0235 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00814 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HSPA1B0.980.75
HSPA60.940.56
DNAJB10.920.60
G0S20.850.39
BAG30.820.46
AL031847.10.670.04
ACRC0.650.04
HSPB10.640.46
SERPINH10.560.51
GPR840.560.29
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MFSD5-0.23-0.03
IFNAR2-0.21-0.07
DOLK-0.200.03
MAN1A2-0.20-0.16
ZNF706-0.19-0.11
CDC42EP2-0.19-0.03
C19orf39-0.19-0.12
TMEM86A-0.19-0.04
MYLK2-0.19-0.14
TRAM1L1-0.19-0.08

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activityIEA-
GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activityISS1944309 
GO:0005488bindingIEA-
GO:0004769steroid delta-isomerase activityISS1944309 
GO:0016853isomerase activityIEA-
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006703estrogen biosynthetic processTAS1944309 
GO:0006702androgen biosynthetic processTAS1944309 
GO:0006700C21-steroid hormone biosynthetic processIEA-
GO:0006694steroid biosynthetic processIEA-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeIDA8274411 
GO:0005739mitochondrionIEA-
GO:0005743mitochondrial inner membraneIDA8274411 
GO:0005758mitochondrial intermembrane spaceIDA8274411 
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0030868smooth endoplasmic reticulum membraneISS-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG STEROID HORMONE BIOSYNTHESIS 5530All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D 3523All SZGR 2.0 genes in this pathway
REACTOME ANDROGEN BIOSYNTHESIS 108All SZGR 2.0 genes in this pathway
REACTOME STEROID HORMONES 2921All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205126All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS UP 8847All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270181All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS UP 10264All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP 9159All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP 9058All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 10772All SZGR 2.0 genes in this pathway