Gene Page: HSD3B1

Summary
GeneID  3283
Symbol  HSD3B1
Synonyms  HSD3B|HSDB3
Description  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
See related  HGNC:5217|MIM:109715|Ensembl:ENSG00000203857|HPRD:04920|
Locus tag  -
Gene type  protein-coding
Map location  1p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HSPA1B0.980.75
HSPA60.940.56
DNAJB10.920.60
G0S20.850.39
BAG30.820.46
AL031847.10.670.04
ACRC0.650.04
HSPB10.640.46
SERPINH10.560.51
GPR840.560.29
Top 10 negatively co-expressed genes
MFSD5-0.23-0.03
IFNAR2-0.21-0.07
DOLK-0.200.03
MAN1A2-0.20-0.16
ZNF706-0.19-0.11
CDC42EP2-0.19-0.03
C19orf39-0.19-0.12
TMEM86A-0.19-0.04
MYLK2-0.19-0.14
TRAM1L1-0.19-0.08
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activityIEA-
GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activityISS1944309 
GO:0005488bindingIEA-
GO:0004769steroid delta-isomerase activityISS1944309 
GO:0016853isomerase activityIEA-
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006703estrogen biosynthetic processTAS1944309 
GO:0006702androgen biosynthetic processTAS1944309 
GO:0006700C21-steroid hormone biosynthetic processIEA-
GO:0006694steroid biosynthetic processIEA-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeIDA8274411 
GO:0005739mitochondrionIEA-
GO:0005743mitochondrial inner membraneIDA8274411 
GO:0005758mitochondrial intermembrane spaceIDA8274411 
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0030868smooth endoplasmic reticulum membraneISS-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_STEROID_HORMONE_BIOSYNTHESIS 5530All SZGR genes in this pathway
REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D 3523All SZGR genes in this pathway
REACTOME_ANDROGEN_BIOSYNTHESIS 108All SZGR genes in this pathway
REACTOME_STEROID_HORMONES 2921All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP 205126All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_UP 8847All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP 10264All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_UP 9159All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_UP 9058All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
ROESSLER_LIVER_CANCER_METASTASIS_UP 10772All SZGR genes in this pathway


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