Gene Page: HSPA6

Summary ?
GeneID3310
SymbolHSPA6
SynonymsHSP70B'
Descriptionheat shock protein family A (Hsp70) member 6
ReferenceMIM:140555|HGNC:HGNC:5239|Ensembl:ENSG00000173110|HPRD:00775|Vega:OTTHUMG00000034461
Gene typeprotein-coding
Map location1q23
Fetal beta-0.853
DMG1 (# studies)
eGeneMyers' cis & trans
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00814 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg187618941161495979HSPA62.59E-50.3070.017DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7547399chr1162134746HSPA633100.01cis
rs16858695chr1162193737HSPA633100.02cis
rs120299980HSPA633102.892E-6trans
rs10733033chr122310261HSPA633102.117E-4trans
rs7543090chr132231154HSPA633100.02trans
rs10493635chr180417215HSPA633100.15trans
rs17129266chr186969109HSPA633100.03trans
rs6593651chr195772660HSPA633100.04trans
rs17120268chr199829635HSPA633100.1trans
rs12072589chr1102074474HSPA633100.16trans
rs11164251chr1102079419HSPA633100.17trans
rs6683395chr1108385120HSPA633104.31E-4trans
rs108020550HSPA633100.02trans
rs12047301chr1209094528HSPA633100.09trans
rs12565778chr1213724810HSPA633100.11trans
rs16838848chr1239900045HSPA633100.11trans
rs10178561chr220484388HSPA633100.11trans
rs10195153chr220551992HSPA633100trans
rs16987610chr220605248HSPA633101.152E-4trans
rs17044609chr223231427HSPA633100.16trans
rs6707600chr224521765HSPA633101.036E-7trans
rs2702079chr224587570HSPA633100.19trans
rs1406236chr229499441HSPA633100.04trans
rs1406237chr229499624HSPA633100.04trans
rs4666189chr229502689HSPA633100.04trans
rs10170219chr274803516HSPA633100.08trans
rs10196599chr276957490HSPA633100.13trans
rs222826chr2146878531HSPA633100.03trans
snp_a-18549140HSPA633100.01trans
rs16840841chr2157641525HSPA633100.01trans
rs7560489chr2158145388HSPA633100.01trans
rs7593761chr2197275602HSPA633102.051E-8trans
rs1882580chr2227518447HSPA633100.01trans
rs10510602chr328023926HSPA633100.16trans
rs12107591chr336751197HSPA633100.1trans
rs9842768chr336751493HSPA633100.04trans
rs9842956chr336751621HSPA633100.06trans
rs2844434chr338390883HSPA633100.01trans
rs17055195chr355369565HSPA633100trans
rs17055216chr355381947HSPA633100trans
rs17055218chr355382206HSPA633100trans
rs17055224chr355383487HSPA633100trans
rs17055232chr355385671HSPA633100trans
rs17055233chr355385691HSPA633100trans
rs6445730chr355386217HSPA633100trans
rs747266chr355387379HSPA633100trans
snp_a-20428180HSPA633100.01trans
rs2365463chr366686263HSPA633100.02trans
rs9883532chr373489258HSPA633100.02trans
rs1840211chr395854993HSPA633100.14trans
rs2614197chr3113311172HSPA633100.03trans
rs16847759chr3168869746HSPA633103.186E-4trans
rs2193745chr3173964139HSPA633100.11trans
rs1805608chr3180771972HSPA633103.549E-5trans
rs7630486chr3189801990HSPA633100trans
rs4692018chr426980718HSPA633100.04trans
rs17086547chr457119142HSPA633100.06trans
rs10000289chr496437605HSPA633100.14trans
rs7694882chr4112309223HSPA633100.11trans
rs12641054chr4113071694HSPA633103.141E-17trans
rs9995457chr4128299300HSPA633100.17trans
rs17056206chr4171733180HSPA633100.09trans
rs4398573chr4188733644HSPA633100trans
rs883525chr56495578HSPA633100.06trans
rs11948869chr56503004HSPA633100.06trans
rs1844691chr523869998HSPA633100.16trans
rs6871776chr524036641HSPA633100.03trans
rs7716468chr524087602HSPA633100.16trans
rs10065849chr530592364HSPA633100.04trans
rs1697073chr530907267HSPA633100.03trans
rs13328131chr535698425HSPA633100.02trans
rs7717250chr559486425HSPA633100.06trans
rs16893719chr564647810HSPA633100.14trans
rs73798950HSPA633100.18trans
rs2289344chr591628223HSPA633100.01trans
rs11956817chr598842089HSPA633101.381E-5trans
rs1422148chr5107526837HSPA633100trans
rs4463170chr5107627192HSPA633100trans
rs12659121chr5107660002HSPA633100trans
rs17161316chr5107756153HSPA633100trans
rs17147528chr5120605704HSPA633100.03trans
rs7718064chr5160556767HSPA633100.01trans
rs9378593chr61100505HSPA633100.14trans
rs200200chr65443639HSPA633100.01trans
rs12663430chr68060533HSPA633100.11trans
rs9392965chr68141268HSPA633100.05trans
rs502759chr618468463HSPA633100.16trans
rs17583852chr632912587HSPA633100.03trans
rs9381009chr640918100HSPA633100.13trans
rs3125579chr698908957HSPA633100.01trans
rs9321410chr6133998132HSPA633100.01trans
rs9402819chr6136848169HSPA633100.06trans
rs9389400chr6136854803HSPA633100.06trans
rs6918404chr6139297610HSPA633100.03trans
rs197485chr6143068177HSPA633101.389E-6trans
rs1424935chr6143699145HSPA633100.11trans
rs3807504chr716684098HSPA633100.06trans
rs17150652chr725012054HSPA633100.1trans
rs343083chr735571887HSPA633100.17trans
rs7808547chr783753166HSPA633100trans
rs3779572chr790608515HSPA633107.699E-4trans
rs1208907chr790654714HSPA633100.07trans
rs3779585chr790719297HSPA633101.604E-4trans
snp_a-20307530HSPA633105.549E-4trans
rs879428chr790737968HSPA633101.604E-4trans
rs2113546chr7134953754HSPA633100.03trans
rs17133801chr7146787365HSPA633106.712E-8trans
rs718119chr83159708HSPA633100.02trans
rs3896041chr83160879HSPA633100.18trans
rs17066062chr83272540HSPA633100.11trans
rs11998339chr88726545HSPA633100.12trans
rs17695317chr818489042HSPA633100.19trans
rs16885771chr836898251HSPA633100.17trans
rs16918960chr854175049HSPA633100.18trans
rs6992596chr854453189HSPA633100.02trans
rs16920160chr855308290HSPA633103.758E-4trans
rs1431586chr864390728HSPA633100trans
rs4263735chr877931285HSPA633100.01trans
rs1483373chr890186442HSPA633100.03trans
rs16876804chr8108825477HSPA633100.05trans
rs10491582chr9953598HSPA633100.03trans
rs2121246chr912037953HSPA633101.603E-6trans
rs11999552chr930351246HSPA633100.03trans
rs7032605chr930426130HSPA633100.1trans
rs10969802chr930636427HSPA633100.02trans
rs10969816chr930661611HSPA633100.02trans
rs12350524chr930743421HSPA633100.02trans
rs12343068chr930783524HSPA633100.02trans
rs10511868chr930816504HSPA633100.02trans
rs3758354chr975764564HSPA633100.16trans
rs914715chr982310897HSPA633100.13trans
rs7026368chr982675015HSPA633100.04trans
rs11140349chr986675586HSPA633100.01trans
rs10868543chr989852686HSPA633101.558E-18trans
rs17053159chr990198374HSPA633100trans
rs3802458chr997741273HSPA633100.18trans
rs3802457chr997741335HSPA633101.391E-5trans
rs10993509chr998071989HSPA633100.09trans
rs10816779chr9111946102HSPA633100.04trans
rs2210142chr9119716771HSPA633100trans
rs7868621chr9132130970HSPA633100.06trans
rs10776917chr9137858478HSPA633109.068E-11trans
rs1335812chr1024119275HSPA633100.02trans
rs602658chr1036007778HSPA633100.04trans
rs1598793chr1079127993HSPA633100.05trans
rs7090588chr1085717555HSPA633100trans
rs12247436chr1085770974HSPA633100.18trans
rs1902680chr1088049777HSPA633100trans
rs17109578chr1090351347HSPA633100trans
rs12218424chr1092958797HSPA633100trans
rs11195998chr10114335289HSPA633100.01trans
rs11196000chr10114337116HSPA633100.01trans
rs3124736chr10115497111HSPA633100.19trans
rs10787671chr10118189794HSPA633100.13trans
rs1431486chr10118193131HSPA633100.02trans
rs17104648chr10124869902HSPA633101.451E-4trans
rs6578285chr111380763HSPA633100trans
rs11824618chr114188729HSPA633100.01trans
rs7948587chr117784541HSPA633100.07trans
rs12286689chr117853932HSPA633100.07trans
rs11022545chr1112933682HSPA633100.1trans
rs16932222chr1115875436HSPA633101.13E-4trans
rs11823900chr1115887003HSPA633106.214E-10trans
rs11603947chr1133486575HSPA633100.15trans
rs7928546chr1136102893HSPA633100.18trans
rs17138435chr1179192986HSPA633100.07trans
rs1499026chr1188433481HSPA633100.08trans
rs10501694chr1188560150HSPA633100.01trans
rs11018448chr1188793318HSPA633100.13trans
rs8181526chr1188797520HSPA633100.04trans
rs2164522chr1189190488HSPA633100.06trans
rs11018625chr1189202568HSPA633100.01trans
rs11018629chr1189206963HSPA633100.07trans
rs614128chr1189214113HSPA633100.03trans
snp_a-22129580HSPA633100.17trans
rs17133063chr1198991111HSPA633100.08trans
rs17119029chr11115857373HSPA633100.01trans
rs1632799chr11115918300HSPA633100trans
rs4759436chr123083708HSPA633100.08trans
rs6489409chr123083951HSPA633100.04trans
rs7953537chr1244693287HSPA633100.06trans
rs17094560chr1244769767HSPA633100.06trans
rs1344796chr1276397104HSPA633108.041E-4trans
rs17046341chr1279472791HSPA633100trans
rs11114260chr1280241492HSPA633100.01trans
rs12304649chr12115144452HSPA633107.987E-4trans
rs12320582chr12115154435HSPA633100.03trans
rs17077917chr1333412452HSPA633100.01trans
rs10492401chr1333489671HSPA633108.988E-4trans
rs9566314chr1338767683HSPA633100trans
rs17070045chr1358400458HSPA633100trans
rs17235614chr1397953192HSPA633100.19trans
rs16960790chr13103589970HSPA633100.12trans
rs12866183chr13103605460HSPA633100.08trans
rs17330244chr13103612897HSPA633100.08trans
rs16966394chr13105986280HSPA633100.07trans
rs7332984chr13108328677HSPA633100trans
rs17109555chr1440132840HSPA633100.01trans
rs17105827chr1472488090HSPA633100.18trans
rs758913chr1473264460HSPA633100.1trans
rs1642278chr1487273027HSPA633100.09trans
rs4503732chr1546642262HSPA633100.05trans
rs16960698chr1548523283HSPA633100trans
rs6494052chr1559295924HSPA633100.03trans
rs16941048chr1559416283HSPA633100.17trans
rs8039102chr1566510617HSPA633100.03trans
rs2278598chr1589174747HSPA633100.05trans
rs10152821chr1589180884HSPA633100.06trans
rs9920555chr1598417871HSPA633100.08trans
rs276614chr1613166182HSPA633100.12trans
rs10492782chr1613210707HSPA633101.071E-14trans
rs7190264chr1623685116HSPA633100trans
rs755295chr1627806317HSPA633100.04trans
rs17821412chr1657938754HSPA633100.03trans
rs4888697chr1677963301HSPA633100.15trans
rs8062753chr1678711589HSPA633100.16trans
rs8082342chr178719237HSPA633100.18trans
rs16944595chr1711242834HSPA633103.799E-4trans
rs16944600chr1711245098HSPA633100.06trans
rs16944601chr1711245219HSPA633100.11trans
rs4924758chr1718367377HSPA633100.01trans
rs792799chr1751176163HSPA633100.14trans
rs16970485chr1775722431HSPA633100.07trans
rs1811086chr1776173021HSPA633100.1trans
rs9956108chr183042415HSPA633105.298E-4trans
rs10468647chr183868774HSPA633105.171E-6trans
rs9807505chr184259102HSPA633100.06trans
rs3744977chr188826082HSPA633100.12trans
snp_a-20369000HSPA633103.783E-5trans
rs7227140chr1810696798HSPA633100.01trans
rs9950823chr1847526879HSPA633100.06trans
rs16951384chr1847527116HSPA633100trans
rs17734946chr1854987388HSPA633100.17trans
rs1942853chr1855195680HSPA633100.16trans
rs7227933chr1857382213HSPA633100.14trans
rs17082636chr1868098567HSPA633100.04trans
rs3935656chr1870947038HSPA633100.05trans
rs48029460HSPA633100trans
rs1673892chr1952974222HSPA633102.314E-4trans
rs979158chr1952976380HSPA633106.406E-4trans
rs4815748chr204822039HSPA633100.09trans
rs362582chr2010254286HSPA633100.01trans
rs362592chr2010272491HSPA633100.19trans
rs362991chr2010276280HSPA633100.14trans
rs363004chr2010279796HSPA633100.13trans
rs8120542chr2024395092HSPA633100trans
rs8114637chr2024395207HSPA633100trans
rs4536719chr2024397114HSPA633100.12trans
rs9974024chr2024397274HSPA633100trans
rs6515493chr2024401635HSPA633100trans
rs6049703chr2024432425HSPA633103.969E-4trans
rs1158857chr2037334090HSPA633100.07trans
rs914136chr2130848367HSPA633100.16trans
rs2832343chr2130849712HSPA633100.09trans
rs963073chr2130867451HSPA633100.16trans
rs7275620chr2130888876HSPA633100.13trans
rs16994521chr2138208009HSPA633100.15trans
rs1894251chr2222440498HSPA633100.03trans
rs1925925chrX69625446HSPA633100.14trans
rs6524459chrX84704458HSPA633108.398E-7trans
rs1293493chrX122175994HSPA633109.945E-4trans
rs9306818chrX143403931HSPA633100.05trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006986response to unfolded proteinTAS2327978 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG SPLICEOSOME 12872All SZGR 2.0 genes in this pathway
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
KEGG ANTIGEN PROCESSING AND PRESENTATION 8965All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
LU TUMOR VASCULATURE UP 2917All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL UP 6938All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS UP 3123All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP 158103All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275168All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP 13680All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP 164122All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP 162116All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239157All SZGR 2.0 genes in this pathway
DUNNE TARGETS OF AML1 MTG8 FUSION UP 5232All SZGR 2.0 genes in this pathway
KAN RESPONSE TO ARSENIC TRIOXIDE 12380All SZGR 2.0 genes in this pathway
HWANG PROSTATE CANCER MARKERS 2819All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355243All SZGR 2.0 genes in this pathway
MAHADEVAN RESPONSE TO MP470 DN 1911All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330217All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS DN 5034All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318215All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178111All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP 9564All SZGR 2.0 genes in this pathway
BACOLOD RESISTANCE TO ALKYLATING AGENTS UP 2617All SZGR 2.0 genes in this pathway
TRACEY RESISTANCE TO IFNA2 DN 3223All SZGR 2.0 genes in this pathway
BILD MYC ONCOGENIC SIGNATURE 206117All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 10567All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292189All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270181All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 14798All SZGR 2.0 genes in this pathway
LU TUMOR ENDOTHELIAL MARKERS UP 2214All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP 7646All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221135All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217131All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP1 13676All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway