SZGR2

Summary ?

GeneID	3320
Symbol	HSP90AA1
Synonyms	EL52\|HEL-S-65p\|HSP86\|HSP89A\|HSP90A\|HSP90N\|HSPC1\|HSPCA\|HSPCAL1\|HSPCAL4\|HSPN\|Hsp89\|Hsp90\|LAP-2\|LAP2
Description	heat shock protein 90kDa alpha family class A member 1
Reference	MIM:140571\|HGNC:HGNC:5253\|Ensembl:ENSG00000080824\|HPRD:00777\|Vega:OTTHUMG00000171752
Gene type	protein-coding
Map location	14q32.33
Pascal p-value	0.299
TADA p-value	0.002
Fetal beta	-0.198
DMG	2 (# studies)
Support	RNA AND PROTEIN SYNTHESIS CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Nishioka_2013	Genome-wide DNA methylation analysis	The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls.	4
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	4
DNM:Fromer_2014	Whole Exome Sequencing analysis	This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.4681

Section I. Genetics and epigenetics annotation

DNM table

Gene	Chromosome	Position	Ref	Alt	Transcript	AA change	Mutation type	Sift	CG46	Trait	Study
HSP90AA1	chr14	102550757	C	CCT	NM_001017963 NM_005348	. .	frameshift frameshift			Schizophrenia	DNM:Fromer_2014

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg13797425	14	102554977	HSP90AA1	1.5E-7	0.741	0.004	DMG:Wockner_2014
cg14893857	14	102554969	HSP90AA1	3.67E-5	0.47	0.02	DMG:Wockner_2014
cg23289024	14	102554846	HSP90AA1	5.143E-4	0.471	0.047	DMG:Wockner_2014
cg04281268	14	102606293	HSP90AA1		-0.02	0.96	DMG:Nishioka_2013

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MON1B	0.90	0.93
UPF1	0.90	0.91
CLEC16A	0.90	0.91
ZFYVE20	0.90	0.90
BICD2	0.89	0.91
POM121	0.89	0.89
DGCR2	0.89	0.90
PCNXL3	0.89	0.88
CLPB	0.89	0.89
TULP4	0.89	0.90

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.21	-0.67	-0.75
C1orf54	-0.64	-0.74
AF347015.31	-0.64	-0.66
GNG11	-0.63	-0.68
MT-CO2	-0.61	-0.65
SYCP3	-0.60	-0.69
HIGD1B	-0.60	-0.63
VAMP5	-0.59	-0.61
AF347015.27	-0.59	-0.63
IFI27	-0.58	-0.58

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	TAS		11470816
GO:0003674	molecular_function	ND		-
GO:0030235	nitric-oxide synthase regulator activity	ISS		-
GO:0005524	ATP binding	TAS		11470816
GO:0051082	unfolded protein binding	IEA		-
GO:0042803	protein homodimerization activity	TAS		11470816
GO:0030911	TPR domain binding	IDA		9660753
GO:0030911	TPR domain binding	TAS		12526792
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006839	mitochondrial transport	TAS	glutamate (GO term level: 6)	12526792
GO:0006457	protein folding	IEA		-
GO:0006986	response to unfolded protein	NAS		2527334
GO:0007165	signal transduction	NAS		11470816
GO:0008150	biological_process	ND		-
GO:0042026	protein refolding	TAS		9660753
GO:0045429	positive regulation of nitric oxide biosynthetic process	ISS		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		9580552 \|10781589
GO:0005829	cytosol	NAS		12526792
GO:0005575	cellular_component	ND		-
GO:0005737	cytoplasm	IEA		-
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AHR	-	aryl hydrocarbon receptor	-	HPRD,BioGRID	7961671 \|9083006
AHSA1	AHA1 \| C14orf3 \| p38	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	in vitro in vivo Two-hybrid	BioGRID	12504007
AHSA1	AHA1 \| C14orf3 \| p38	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	-	HPRD	12604615
AHSA2	DKFZp564C236 \| FLJ34679 \| FLJ41715 \| Hch1	AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)	-	HPRD,BioGRID	12504007 \|14739935
AIP	ARA9 \| FKBP16 \| FKBP37 \| SMTPHN \| XAP2	aryl hydrocarbon receptor interacting protein	-	HPRD	9111057 \|9837941
AIP	ARA9 \| FKBP16 \| FKBP37 \| SMTPHN \| XAP2	aryl hydrocarbon receptor interacting protein	Affinity Capture-Western	BioGRID	11013261
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD,BioGRID	10995457
AKT2	PKBB \| PKBBETA \| PRKBB \| RAC-BETA	v-akt murine thymoma viral oncogene homolog 2	-	HPRD	11988487
ALK	CD246 \| Ki-1 \| TFG/ALK	anaplastic lymphoma receptor tyrosine kinase	-	HPRD	11888936
APAF1	CED4 \| DKFZp781B1145	apoptotic peptidase activating factor 1	Affinity Capture-Western	BioGRID	10934467
APOB	FLDB	apolipoprotein B (including Ag(x) antigen)	-	HPRD	11333259
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	1525041
ARNT	HIF-1beta \| HIF1B \| HIF1BETA \| TANGO \| bHLHe2	aryl hydrocarbon receptor nuclear translocator	Affinity Capture-Western	BioGRID	11013261
ARNTL	BMAL1 \| BMAL1c \| JAP3 \| MGC47515 \| MOP3 \| PASD3 \| TIC \| bHLHe5	aryl hydrocarbon receptor nuclear translocator-like	-	HPRD,BioGRID	9079689
ASGR1	ASGPR \| CLEC4H1 \| Hs.12056	asialoglycoprotein receptor 1	-	HPRD	12167617
BAG4	BAG-4 \| SODD	BCL2-associated athanogene 4	Affinity Capture-Western	BioGRID	14559896
BIRC5	API4 \| EPR-1	baculoviral IAP repeat-containing 5	Survivin interacts with Hsp90.	BIND	15894266
CALM1	CALML2 \| CAMI \| DD132 \| PHKD	calmodulin 1 (phosphorylase kinase, delta)	-	HPRD	8486648
CDC37	P50CDC37	cell division cycle 37 homolog (S. cerevisiae)	Co-crystal Structure in vitro	BioGRID	9685350 \|14718169
CDC37	P50CDC37	cell division cycle 37 homolog (S. cerevisiae)	-	HPRD	9685350\|14718169
CHTF18	C16orf41 \| C321D2.2 \| C321D2.3 \| C321D2.4 \| CHL12 \| Ctf18 \| RUVBL	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	12930902
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	-	HPRD	11864612
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	-	HPRD,BioGRID	7794926
CSNK2A2	CK2A2 \| CSNK2A1 \| FLJ43934	casein kinase 2, alpha prime polypeptide	-	HPRD,BioGRID	7794926
CUL4A	-	cullin 4A	Affinity Capture-MS	BioGRID	12481031
DAP3	DAP-3 \| DKFZp686G12159 \| MGC126058 \| MGC126059 \| MRP-S29 \| MRPS29 \| bMRP-10	death associated protein 3	-	HPRD,BioGRID	10903152
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	EGFR interacts with Hsp90. This interaction was modeled on a demonstrated interaction between EGFR from an unspecified species and human Hsp90.	BIND	12471035
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	-	HPRD,BioGRID	11447118
EIF2AK3	DKFZp781H1925 \| HRI \| PEK \| PERK \| WRS	eukaryotic translation initiation factor 2-alpha kinase 3	-	HPRD,BioGRID	12446770
EPRS	DKFZp313B047 \| EARS \| GLUPRORS \| PARS \| PIG32 \| QARS \| QPRS	glutamyl-prolyl-tRNA synthetase	-	HPRD,BioGRID	10913161
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	ERBB2 interacts with HSP90. This interaction was modelled on a demonstrated interaction between human ERBB2 and monkey HSP90.	BIND	15643424
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	-	HPRD,BioGRID	11071886
ERN1	FLJ30999 \| IRE1 \| IRE1P \| MGC163277 \| MGC163279	endoplasmic reticulum to nucleus signaling 1	-	HPRD,BioGRID	12446770
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	-	HPRD,BioGRID	11911945
FANCA	FA \| FA-H \| FA1 \| FAA \| FACA \| FAH \| FANCH \| MGC75158	Fanconi anemia, complementation group A	Two-hybrid	BioGRID	14499622
FANCC	FA3 \| FAC \| FACC \| FLJ14675	Fanconi anemia, complementation group C	Two-hybrid	BioGRID	14499622
FES	FPS	feline sarcoma oncogene	Reconstituted Complex	BioGRID	9222609
FKBP5	FKBP51 \| FKBP54 \| MGC111006 \| P54 \| PPIase \| Ptg-10	FK506 binding protein 5	-	HPRD,BioGRID	9001212 \|12538866
FNIP1	DKFZp686E18167 \| DKFZp781P0215 \| KIAA1961 \| MGC667	folliculin interacting protein 1	Affinity Capture-MS	BioGRID	17028174
GNA12	MGC104623 \| MGC99644 \| NNX3 \| RMP \| gep	guanine nucleotide binding protein (G protein) alpha 12	in vitro in vivo Two-hybrid	BioGRID	11598136 \|12117999
GNA12	MGC104623 \| MGC99644 \| NNX3 \| RMP \| gep	guanine nucleotide binding protein (G protein) alpha 12	-	HPRD	11598136\|12117999
GUCY1B3	GC-S-beta-1 \| GC-SB3 \| GUC1B3 \| GUCB3 \| GUCSB3 \| GUCY1B1	guanylate cyclase 1, soluble, beta 3	-	HPRD,BioGRID	12676772
HCFC1	CFF \| HCF-1 \| HCF1 \| HFC1 \| MGC70925 \| VCAF	host cell factor C1 (VP16-accessory protein)	Affinity Capture-MS	BioGRID	12670868
HIF1A	HIF-1alpha \| HIF1 \| HIF1-ALPHA \| MOP1 \| PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	-	HPRD,BioGRID	9079689
HSF1	HSTF1	heat shock transcription factor 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9222609 \|12621024
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	Two-hybrid	BioGRID	16169070
HSPA1A	FLJ54303 \| FLJ54370 \| FLJ54392 \| FLJ54408 \| FLJ75127 \| HSP70-1 \| HSP70-1A \| HSP70I \| HSP72 \| HSPA1 \| HSPA1B	heat shock 70kDa protein 1A	Reconstituted Complex	BioGRID	12093808
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	-	HPRD,BioGRID	9269769
IKBKB	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	-	HPRD	11864612
IKBKG	AMCBX1 \| FIP-3 \| FIP3 \| Fip3p \| IKK-gamma \| IP \| IP1 \| IP2 \| IPD2 \| NEMO	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	-	HPRD	11864612
IRS4	IRS-4 \| PY160	insulin receptor substrate 4	Affinity Capture-MS	BioGRID	11912194
LSM1	CASM \| YJL124C	LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-	HPRD,BioGRID	15231747
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	-	HPRD	14743216
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	-	HPRD	14743216
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	-	HPRD	11748628
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	-	HPRD,BioGRID	12644583
MYOD1	MYF3 \| MYOD \| PUM \| bHLHc1	myogenic differentiation 1	-	HPRD,BioGRID	1406681
NOS3	ECNOS \| eNOS	nitric oxide synthase 3 (endothelial cell)	-	HPRD,BioGRID	11744239 \|12124224
NPAS2	FLJ23138 \| MGC71151 \| MOP4 \| PASD4 \| bHLHe9	neuronal PAS domain protein 2	Reconstituted Complex	BioGRID	9079689
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	8621522 \|8645634 \|8898375 \|9334248 \|10066374
NR3C2	MCR \| MGC133092 \| MLR \| MR	nuclear receptor subfamily 3, group C, member 2	-	HPRD	9392437
PDPK1	MGC20087 \| MGC35290 \| PDK1 \| PRO0461	3-phosphoinositide dependent protein kinase-1	-	HPRD	11779851
PIM1	PIM	pim-1 oncogene	-	HPRD,BioGRID	11237709
PPARA	MGC2237 \| MGC2452 \| NR1C1 \| PPAR \| hPPAR	peroxisome proliferator-activated receptor alpha	-	HPRD,BioGRID	12482853
PPID	CYP-40 \| CYPD \| MGC33096	peptidylprolyl isomerase D	-	HPRD	12145316
PPP5C	FLJ36922 \| PP5 \| PPP5	protein phosphatase 5, catalytic subunit	-	HPRD	10400612
PPP5C	FLJ36922 \| PP5 \| PPP5	protein phosphatase 5, catalytic subunit	Hsp90 interacts with PP5. This interaction was modeled on a demonstrated interaction between human Hsp90 and PP5 from an unspecified species.	BIND	15664193
PTGES3	P23 \| TEBP \| cPGES	prostaglandin E synthase 3 (cytosolic)	-	HPRD,BioGRID	11812147 \|12077419
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	Raf-1 interacts with Hsp90. This interaction was modeled on a demonstrated interaction between human Raf-1 and monkey Hsp90.	BIND	15618521
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	8408024
RALBP1	RIP1 \| RLIP1 \| RLIP76	ralA binding protein 1	Affinity Capture-Western	BioGRID	12621024
RIPK1	FLJ39204 \| RIP \| RIP1	receptor (TNFRSF)-interacting serine-threonine kinase 1	-	HPRD	10744744
RPS3A	FTE1 \| MFTL \| MGC23240	ribosomal protein S3A	Two-hybrid	BioGRID	16169070
RUNX1T1	AML1T1 \| CBFA2T1 \| CDR \| ETO \| MGC2796 \| MTG8 \| MTG8b \| ZMYND2	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	-	HPRD	10076566
SGTA	SGT \| alphaSGT \| hSGT	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	-	HPRD,BioGRID	12482202
SIM1	bHLHe14	single-minded homolog 1 (Drosophila)	Reconstituted Complex	BioGRID	9020169
SMYD3	FLJ21080 \| MGC104324 \| ZMYND1 \| ZNFN3A1 \| bA74P14.1	SET and MYND domain containing 3	SMYD3 interacts with HSP90A.	BIND	15235609
SMYD3	FLJ21080 \| MGC104324 \| ZMYND1 \| ZNFN3A1 \| bA74P14.1	SET and MYND domain containing 3	-	HPRD,BioGRID	15235609
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	1310678
STARD13	DLC2 \| FLJ37385 \| GT650	StAR-related lipid transfer (START) domain containing 13	Two-hybrid	BioGRID	14697242
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	-	HPRD,BioGRID	12559950
STIP1	HOP \| IEF-SSP-3521 \| P60 \| STI1 \| STI1L	stress-induced-phosphoprotein 1	-	HPRD,BioGRID	10786835
STK11	LKB1 \| PJS	serine/threonine kinase 11	Affinity Capture-Western Reconstituted Complex	BioGRID	12489981
STUB1	CHIP \| HSPABP2 \| NY-CO-7 \| SDCCAG7 \| UBOX1	STIP1 homology and U-box containing protein 1	-	HPRD	11146632\|11557750
TERT	EST2 \| TCS1 \| TP2 \| TRT \| hEST2	telomerase reverse transcriptase	-	HPRD,BioGRID	12586360
TNFRSF1A	CD120a \| FPF \| MGC19588 \| TBP1 \| TNF-R \| TNF-R-I \| TNF-R55 \| TNFAR \| TNFR1 \| TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	tumor necrosis factor receptor superfamily, member 1A	-	HPRD	7876093
TOMM34	HTOM34P \| TOM34 \| URCC3	translocase of outer mitochondrial membrane 34	-	HPRD	9660753
TOMM70A	FLJ90470	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	-	HPRD	12526792
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	11507088 \|12427754
TRADD	Hs.89862 \| MGC11078	TNFRSF1A-associated via death domain	-	HPRD	14743216
TUBA1A	B-ALPHA-1 \| FLJ25113 \| LIS3 \| TUBA3	tubulin, alpha 1a	Affinity Capture-Western	BioGRID	12621024
WASL	DKFZp779G0847 \| MGC48327 \| N-WASP \| NWASP	Wiskott-Aldrich syndrome-like	WASL (N-WASP) interacts with HSPCA (HSP90-alpha).	BIND	15791211

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ANTIGEN PROCESSING AND PRESENTATION	89	65	All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY	62	47	All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION	86	59	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
BIOCARTA NO1 PATHWAY	33	24	All SZGR 2.0 genes in this pathway
BIOCARTA AKT PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA GCR PATHWAY	22	17	All SZGR 2.0 genes in this pathway
BIOCARTA P53HYPOXIA PATHWAY	23	21	All SZGR 2.0 genes in this pathway
BIOCARTA HIF PATHWAY	15	12	All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA TEL PATHWAY	18	15	All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY	34	27	All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY	79	62	All SZGR 2.0 genes in this pathway
PID ILK PATHWAY	45	32	All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY	47	37	All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY	68	48	All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY	82	60	All SZGR 2.0 genes in this pathway
PID PI3KCI PATHWAY	49	40	All SZGR 2.0 genes in this pathway
PID IL2 PI3K PATHWAY	34	27	All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY	53	38	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID HIF1A PATHWAY	19	12	All SZGR 2.0 genes in this pathway
PID ERBB NETWORK PATHWAY	15	13	All SZGR 2.0 genes in this pathway
PID VEGFR1 PATHWAY	26	23	All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY	69	57	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	13	9	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	18	13	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME ENOS ACTIVATION AND REGULATION	20	14	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	66	43	All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	59	38	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	15	14	All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS	68	53	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES	81	50	All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE	203	72	All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	169	47	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP	285	181	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP	408	247	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS TOP50 UP	38	27	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP	119	66	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP	276	165	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP	139	83	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP	341	197	All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN	73	51	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP	164	122	All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP	214	134	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP	265	158	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP	128	95	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN	75	50	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
MARKS ACETYLATED NON HISTONE PROTEINS	15	9	All SZGR 2.0 genes in this pathway
SEIDEN ONCOGENESIS BY MET	88	53	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS	58	45	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
COLLIS PRKDC SUBSTRATES	20	15	All SZGR 2.0 genes in this pathway
MENSSEN MYC TARGETS	53	35	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN	187	122	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK	169	111	All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC UP	62	38	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA UP	45	30	All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN	245	154	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP	151	103	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
APRELIKOVA BRCA1 TARGETS	49	33	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN	215	132	All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT	51	41	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN	165	106	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1	72	45	All SZGR 2.0 genes in this pathway
WENG POR TARGETS GLOBAL DN	23	14	All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP	113	71	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
CHENG RESPONSE TO NICKEL ACETATE	45	29	All SZGR 2.0 genes in this pathway
WENG POR TARGETS LIVER DN	20	11	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2	473	224	All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP	125	68	All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 DN	78	49	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL UP	51	32	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE	101	76	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN	374	217	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
GUO TARGETS OF IRS1 AND IRS2	98	67	All SZGR 2.0 genes in this pathway
FU INTERACT WITH ALKBH8	13	8	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-361	46	53	1A,m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-495	82	88	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: HSP90AA1