SZGR2

Summary ?

GeneID	338
Symbol	APOB
Synonyms	FLDB\|LDLCQ4\|apoB-100\|apoB-48
Description	apolipoprotein B
Reference	MIM:107730\|HGNC:HGNC:603\|Ensembl:ENSG00000084674\|HPRD:00133\|Vega:OTTHUMG00000090785
Gene type	protein-coding
Map location	2p24-p23
Pascal p-value	0.689
Fetal beta	-0.366
eGene	Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
VAMP5	0.76	0.84
C1orf54	0.74	0.82
GNG11	0.69	0.70
C1orf61	0.69	0.72
METRN	0.69	0.86
AL138743.2	0.68	0.69
IFI27	0.68	0.86
AF347015.21	0.67	0.81
S100A13	0.67	0.80
IFI27L2	0.67	0.73

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ADD1	-0.64	-0.79
VPS52	-0.63	-0.57
DDX42	-0.63	-0.77
AC119673.2	-0.62	-0.67
RABGAP1	-0.62	-0.75
RABGEF1	-0.61	-0.78
EIF4ENIF1	-0.61	-0.81
CSRP2BP	-0.61	-0.71
HNRNPH2	-0.61	-0.67
ARFGAP2	-0.61	-0.66

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BGN	DSPG1 \| PG-S1 \| PGI \| SLRR1A	biglycan	-	HPRD,BioGRID	12070165
CALCR	CRT \| CTR \| CTR1	calcitonin receptor	Affinity Capture-RNA Affinity Capture-Western Co-fractionation	BioGRID	9694898 \|12397072
CALR	CRT \| FLJ26680 \| RO \| SSA \| cC1qR	calreticulin	-	HPRD,BioGRID	10513896 \|12397072
CANX	CNX \| FLJ26570 \| IP90 \| P90	calnexin	Affinity Capture-Western	BioGRID	14498830
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD	11333259
HSP90B1	ECGP \| GP96 \| GRP94 \| TRA1	heat shock protein 90kDa beta (Grp94), member 1	-	HPRD,BioGRID	12397072
HSPA1A	FLJ54303 \| FLJ54370 \| FLJ54392 \| FLJ54408 \| FLJ75127 \| HSP70-1 \| HSP70-1A \| HSP70I \| HSP72 \| HSPA1 \| HSPA1B	heat shock 70kDa protein 1A	-	HPRD	9252351
HSPA5	BIP \| FLJ26106 \| GRP78 \| MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	-	HPRD	12397072
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	-	HPRD	9694898
LDLR	FH \| FHC	low density lipoprotein receptor	-	HPRD	12031600
LIPC	HDLCQ12 \| HL \| HTGL \| LIPH	lipase, hepatic	-	HPRD,BioGRID	9685400
LRP2	DBS \| gp330	low density lipoprotein-related protein 2	-	HPRD	10330424
MTTP	ABL \| MGC149819 \| MGC149820 \| MTP	microsomal triglyceride transfer protein	-	HPRD,BioGRID	9915855 \|11358959
PDIA4	ERP70 \| ERP72	protein disulfide isomerase family A, member 4	-	HPRD,BioGRID	9694898 \|12397072
PPIB	CYP-S1 \| CYPB \| MGC14109 \| MGC2224 \| SCYLP	peptidylprolyl isomerase B (cyclophilin B)	-	HPRD,BioGRID	12397072
SEC61A1	HSEC61 \| SEC61 \| SEC61A	Sec61 alpha 1 subunit (S. cerevisiae)	Affinity Capture-Western	BioGRID	9565615
SEC61A2	FLJ10578	Sec61 alpha 2 subunit (S. cerevisiae)	-	HPRD	9565615
SEC61B	-	Sec61 beta subunit	-	HPRD,BioGRID	9565615

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID AMB2 NEUTROPHILS PATHWAY	41	32	All SZGR 2.0 genes in this pathway
PID HNF3A PATHWAY	44	29	All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	91	65	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS	78	49	All SZGR 2.0 genes in this pathway
REACTOME PLATELET SENSITIZATION BY LDL	16	9	All SZGR 2.0 genes in this pathway
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT	46	37	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME LIPOPROTEIN METABOLISM	28	24	All SZGR 2.0 genes in this pathway
REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	16	15	All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP	158	103	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION L0 L1 UP	17	12	All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES	244	154	All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION UP	74	51	All SZGR 2.0 genes in this pathway
SU LIVER	55	32	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN	88	58	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN	96	71	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN	540	340	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
MATZUK SPERMATOZOA	114	77	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN	222	141	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING UP	93	62	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway

Gene Page: APOB