Gene Page: FAS

Summary
GeneID  355
Symbol  FAS
Synonyms  ALPS1A|APO-1|APT1|CD95|FAS1|FASTM|TNFRSF6
Description  Fas (TNF receptor superfamily, member 6)
See related  HGNC:11920|MIM:134637|Ensembl:ENSG00000026103|HPRD:00609|
Locus tag  -
Gene type  protein-coding
Map location  10q24.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 2.86 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0203 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FAM188B0.940.74
GFAP0.830.89
PLIN0.710.75
RASL120.700.77
ITGB40.670.79
EFEMP10.670.79
METTL7B0.650.68
ACSM50.640.63
NUPR10.640.77
STK19P0.630.59
Top 10 negatively co-expressed genes
STMN1-0.36-0.63
PLEKHO1-0.36-0.61
ZBTB8A-0.35-0.62
NKIRAS2-0.35-0.62
KIAA1949-0.35-0.58
MPP3-0.34-0.61
ZNF821-0.34-0.60
TUBB2B-0.34-0.58
DUSP12-0.34-0.62
BZW2-0.34-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004888transmembrane receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0042802identical protein bindingIPI7536190 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006461protein complex assemblyTAS10875918 
GO:0007165signal transductionIEA-
GO:0007165signal transductionTAS9360929 
GO:0008633activation of pro-apoptotic gene productsEXP14644197 
GO:0006955immune responseIEA-
GO:0006916anti-apoptosisTAS7510905 
GO:0006915apoptosisIEA-
GO:0008624induction of apoptosis by extracellular signalsEXP11048727 
GO:0042981regulation of apoptosisNAS7533181 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolNAS7533181 
GO:0005576extracellular regionIEA-
GO:0005625soluble fractionTAS7510905 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneEXP7530336 |7536190 |8521815 
|8681376 |9721089 
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alphaCo-purificationBioGRID15659383 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonistCo-purificationBioGRID15659383 
BTKAGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLABruton agammaglobulinemia tyrosine kinase-HPRD9751072 
C14orf1ERG28 | NET51chromosome 14 open reading frame 1Two-hybridBioGRID16169070 
C1orf103FLJ11269 | RIF1 | RP11-96K19.1chromosome 1 open reading frame 103Two-hybridBioGRID16169070 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidase-HPRD,BioGRID9045686 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD11101867 
Affinity Capture-Western
Co-purification		BioGRID9208847 |9325248 
|15659383 
CASP8AP2CED-4 | FLASH | FLJ11208 | KIAA1315 | RIP25caspase 8 associated protein 2-HPRD,BioGRID10235259 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulatorAffinity Capture-WesternBioGRID9208847 |9325248 
CRMP1DPYSL1 | DRP-1 | DRP1collapsin response mediator protein 1Two-hybridBioGRID16169070 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaCTNNB1 (beta-catenin) interacts with the FAS promoter.BIND15829968 
DAXXBING2 | DAP6 | EAP1 | MGC126245 | MGC126246death-domain associated proteinReconstituted ComplexBioGRID11483955 
-HPRD9215629 |11193028 
EEF1A1CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1eukaryotic translation elongation factor 1 alpha 1Two-hybridBioGRID16169070 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinCo-purificationBioGRID15659383 
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domainFas interacts with FADD.BIND15383280 
An unspecified isoform of Fas interacts with FADD.BIND15665818 
-HPRD,BioGRID7538907 |8967952 
-HPRD7536190 |7538907 
|8967952|7538907 |8967952 
FAF1CGI-03 | FLJ37524 | HFAF1s | UBXD12 | UBXN3A | hFAF1Fas (TNFRSF6) associated factor 1-HPRD,BioGRID8524870 |9740801 
FAIM2KIAA0950 | LFG | NGP35 | NMP35 | TMBIM2Fas apoptotic inhibitory molecule 2-HPRD,BioGRID10535980 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)Two-hybridBioGRID7538908 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)-HPRD,BioGRID9126929 |9228058 
FBF1Alb | FBF-1 | FLJ00103Fas (TNFRSF6) binding factor 1-HPRD,BioGRID10978533 
FEM1BDKFZp451E0710 | FIAAfem-1 homolog b (C. elegans)-HPRD10542291 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID8626376 
HIPK3DYRK6 | FIST3 | PKY | YAK1homeodomain interacting protein kinase 3-HPRD,BioGRID11034606 
KAT5ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2K(lysine) acetyltransferase 5HTATIP (Tip60) interacts with the FAS promoter.BIND15829968 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID8864141 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8Co-purificationBioGRID15659383 
MSN-moesinCo-purificationBioGRID15659383 
NOL3ARC | CARD2 | MYC | MYP | NOP | NOP30nucleolar protein 3 (apoptosis repressor with CARD domain)ARC interacts with an unspecified isoform of Fas.BIND15383280 
Phenotypic SuppressionBioGRID9560245 
PDCD6ALG-2 | FLJ46208 | MGC111017 | MGC119050 | MGC9123 | PEF1Bprogrammed cell death 6-HPRD,BioGRID11606059 
PTPN13DKFZp686J1497 | FAP-1 | PNP1 | PTP-BAS | PTP-BL | PTP1E | PTPL1 | PTPLEprotein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)-HPRD7536343 |9079683 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member ACo-purificationBioGRID15659383 
RIPK1FLJ39204 | RIP | RIP1receptor (TNFRSF)-interacting serine-threonine kinase 1-HPRD,BioGRID7538908 |9740801 
RUVBL2CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49BRuvB-like 2 (E. coli)RUVBL2 (reptin) interacts with the FAS promoter.BIND15829968 
SUMO1DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)Reconstituted Complex
Two-hybrid		BioGRID8906799 |11112409 
Fas interacts with sentrin.BIND11112409 
-HPRD8906799 |9740801 
TNFRSF10BCD262 | DR5 | KILLER | KILLER/DR5 | TRAIL-R2 | TRAILR2 | TRICK2 | TRICK2A | TRICK2B | TRICKB | ZTNFR9tumor necrosis factor receptor superfamily, member 10bCo-purificationBioGRID15659383 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1ACo-purificationBioGRID15659383 
TNFSF12-TNFSF13TWE-PRILTNFSF12-TNFSF13 readthrough transcript-HPRD10706119 
TNFSF13APRIL | CD256 | TALL2 | TRDL-1 | UNQ383/PRO715 | ligandtumor necrosis factor (ligand) superfamily, member 13Reconstituted ComplexBioGRID10706119 
TP63AIS | B(p51A) | B(p51B) | EEC3 | KET | LMS | NBP | OFC8 | RHS | SHFM4 | TP53CP | TP53L | TP73L | p40 | p51 | p53CP | p63 | p73H | p73Ltumor protein p63p63 interacts with CD95.BIND15944736 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD8681376 |9427646 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)-HPRD,BioGRID9257699 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_P53_SIGNALING_PATHWAY 6945All SZGR genes in this pathway
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_TYPE_I_DIABETES_MELLITUS 4438All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_AUTOIMMUNE_THYROID_DISEASE 5349All SZGR genes in this pathway
KEGG_ALLOGRAFT_REJECTION 3834All SZGR genes in this pathway
KEGG_GRAFT_VERSUS_HOST_DISEASE 4231All SZGR genes in this pathway
BIOCARTA_ASBCELL_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_CTL_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_FAS_PATHWAY 3022All SZGR genes in this pathway
BIOCARTA_TCAPOPTOSIS_PATHWAY 118All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_IL2RB_PATHWAY 3826All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY 4638All SZGR genes in this pathway
BIOCARTA_PML_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_HSP27_PATHWAY 1511All SZGR genes in this pathway
SA_CASPASE_CASCADE 1913All SZGR genes in this pathway
SA_FAS_SIGNALING 95All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
PID_P73PATHWAY 7959All SZGR genes in this pathway
PID_FAS_PATHWAY 3829All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_HIV_NEF_PATHWAY 3526All SZGR genes in this pathway
PID_TAP63_PATHWAY 5440All SZGR genes in this pathway
REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS 138All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_UP 2518All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
WANG_CLIM2_TARGETS_DN 186114All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
HAHTOLA_SEZARY_SYNDROM_UP 9858All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP 5540All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN 5135All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_DN 228137All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
BARRIER_CANCER_RELAPSE_NORMAL_SAMPLE_UP 3221All SZGR genes in this pathway
KERLEY_RESPONSE_TO_CISPLATIN_UP 4430All SZGR genes in this pathway
MARKS_HDAC_TARGETS_UP 2315All SZGR genes in this pathway
BAKER_HEMATOPOIESIS_STAT3_TARGETS 1612All SZGR genes in this pathway
DUTTA_APOPTOSIS_VIA_NFKB 3325All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_6 8454All SZGR genes in this pathway
SCHAVOLT_TARGETS_OF_TP53_AND_TP63 1612All SZGR genes in this pathway
DACOSTA_LOW_DOSE_UV_RESPONSE_VIA_ERCC3_XPCS_UP 1810All SZGR genes in this pathway
CEBALLOS_TARGETS_OF_TP53_AND_MYC_DN 3831All SZGR genes in this pathway
TSAI_RESPONSE_TO_IONIZING_RADIATION 149101All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
ALCALA_APOPTOSIS 8860All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_DN 10371All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
JEON_SMAD6_TARGETS_UP 2415All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_8 3628All SZGR genes in this pathway
DER_IFN_ALPHA_RESPONSE_UP 7448All SZGR genes in this pathway
KANNAN_TP53_TARGETS_UP 5840All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGLL_VS_IGLK_UP 4224All SZGR genes in this pathway
DER_IFN_GAMMA_RESPONSE_UP 7145All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
HALMOS_CEBPA_TARGETS_UP 5234All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_UP 2622All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
HOEGERKORP_CD44_TARGETS_TEMPORAL_UP 138All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_UP 7149All SZGR genes in this pathway
ONGUSAHA_TP53_TARGETS 3823All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
CHUANG_OXIDATIVE_STRESS_RESPONSE_UP 2818All SZGR genes in this pathway
WU_HBX_TARGETS_3_UP 1811All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
WU_HBX_TARGETS_1_UP 1610All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_UP 9564All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C1 2414All SZGR genes in this pathway
WU_HBX_TARGETS_2_UP 2313All SZGR genes in this pathway
HAN_JNK_SINGALING_DN 3927All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_DN 3624All SZGR genes in this pathway
FUJII_YBX1_TARGETS_UP 4328All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
SEKI_INFLAMMATORY_RESPONSE_LPS_UP 7756All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP 10767All SZGR genes in this pathway
SCHRAETS_MLL_TARGETS_UP 3521All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN 6746All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G123_DN 5130All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP 13993All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_UP 169105All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_10HR_UP 5438All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN 9974All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_2HR_UP 5333All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_UP 16697All SZGR genes in this pathway
GHANDHI_DIRECT_IRRADIATION_UP 11068All SZGR genes in this pathway
WARTERS_RESPONSE_TO_IR_SKIN 8344All SZGR genes in this pathway
WARTERS_IR_RESPONSE_5GY 4723All SZGR genes in this pathway


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