Gene Page: IL3

Summary
GeneID  3562
Symbol  IL3
Synonyms  IL-3|MCGF|MGC79398|MGC79399|MULTI-CSF
Description  interleukin 3 (colony-stimulating factor, multiple)
See related  HGNC:6011|MIM:147740|Ensembl:ENSG00000164399|HPRD:00987|
Locus tag  -
Gene type  protein-coding
Map location  5q31.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.0032 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
B3GAT10.710.69
NUMB0.700.70
MON1B0.690.72
SPRY30.680.68
BCR0.680.72
PHACTR10.670.71
CTNND20.670.69
C6orf1200.660.71
RUNDC10.660.72
NTRK30.660.72
Top 10 negatively co-expressed genes
AL139819.3-0.49-0.57
AF347015.21-0.47-0.51
MT-CO2-0.44-0.46
AF347015.31-0.44-0.46
SYCP3-0.43-0.51
GNG11-0.43-0.48
HIGD1B-0.42-0.43
IL32-0.42-0.46
AF347015.8-0.41-0.44
AF347015.2-0.41-0.39
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005135interleukin-3 receptor bindingTAS2544122 
GO:0005125cytokine activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)9736740 
GO:0007267cell-cell signalingTAS3497400 
GO:0008284positive regulation of cell proliferationISS-
GO:0006955immune responseIEA-
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIDA9722506 
GO:0043066negative regulation of apoptosisIEA-
GO:0019221cytokine-mediated signaling pathwayIEA-
GO:0045740positive regulation of DNA replicationIDA9722506 
GO:0045885positive regulation of survival gene product expressionISS-
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationISS-
GO:0046330positive regulation of JNK cascadeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceISS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CSF2RBCD131 | CDw131 | IL3RB | IL5RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)Reconstituted ComplexBioGRID8649415 
-HPRD9278420 
IL3RACD123 | IL3R | IL3RAY | IL3RX | IL3RY | MGC34174 | hIL-3Rainterleukin 3 receptor, alpha (low affinity)-HPRD8649415|9278420 
Reconstituted ComplexBioGRID7957082 |8649415 
PIK3CDp110Dphosphoinositide-3-kinase, catalytic, delta polypeptide-HPRD9113989 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 7958All SZGR genes in this pathway
KEGG_ASTHMA 3025All SZGR genes in this pathway
BIOCARTA_CYTOKINE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_INFLAM_PATHWAY 2924All SZGR genes in this pathway
BIOCARTA_DC_PATHWAY 2220All SZGR genes in this pathway
BIOCARTA_ERYTH_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_IL17_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_IL3_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_BAD_PATHWAY 2623All SZGR genes in this pathway
BIOCARTA_STEM_PATHWAY 1513All SZGR genes in this pathway
PID_NFAT_TFPATHWAY 4739All SZGR genes in this pathway
PID_IL3_PATHWAY 2719All SZGR genes in this pathway
PID_TCR_CALCIUM_PATHWAY 2923All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 4334All SZGR genes in this pathway
REACTOME_IL_RECEPTOR_SHC_SIGNALING 2721All SZGR genes in this pathway
REACTOME_IL_2_SIGNALING 4134All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS 2418All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_UP 5035All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH 6042All SZGR genes in this pathway
MCCLUNG_COCAIN_REWARD_4WK 7547All SZGR genes in this pathway
RAY_ALZHEIMERS_DISEASE 137All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_DN 8859All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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