Gene Page: IL3

Summary ?
GeneID3562
SymbolIL3
SynonymsIL-3|MCGF|MULTI-CSF
Descriptioninterleukin 3
ReferenceMIM:147740|HGNC:HGNC:6011|Ensembl:ENSG00000164399|HPRD:00987|Vega:OTTHUMG00000059640
Gene typeprotein-coding
Map location5q31.1
Pascal p-value0.309
Fetal beta-0.109

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_IGenome scan meta-analysisPsr: 0.0032 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
B3GAT10.710.69
NUMB0.700.70
MON1B0.690.72
SPRY30.680.68
BCR0.680.72
PHACTR10.670.71
CTNND20.670.69
C6orf1200.660.71
RUNDC10.660.72
NTRK30.660.72
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AL139819.3-0.49-0.57
AF347015.21-0.47-0.51
MT-CO2-0.44-0.46
AF347015.31-0.44-0.46
SYCP3-0.43-0.51
GNG11-0.43-0.48
HIGD1B-0.42-0.43
IL32-0.42-0.46
AF347015.8-0.41-0.44
AF347015.2-0.41-0.39

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005135interleukin-3 receptor bindingTAS2544122 
GO:0005125cytokine activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)9736740 
GO:0007267cell-cell signalingTAS3497400 
GO:0008284positive regulation of cell proliferationISS-
GO:0006955immune responseIEA-
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIDA9722506 
GO:0043066negative regulation of apoptosisIEA-
GO:0019221cytokine-mediated signaling pathwayIEA-
GO:0045740positive regulation of DNA replicationIDA9722506 
GO:0045885positive regulation of survival gene product expressionISS-
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationISS-
GO:0046330positive regulation of JNK cascadeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceISS-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS 8862All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155105All SZGR 2.0 genes in this pathway
KEGG HEMATOPOIETIC CELL LINEAGE 8860All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY 7958All SZGR 2.0 genes in this pathway
KEGG ASTHMA 3025All SZGR 2.0 genes in this pathway
BIOCARTA CYTOKINE PATHWAY 2216All SZGR 2.0 genes in this pathway
BIOCARTA INFLAM PATHWAY 2924All SZGR 2.0 genes in this pathway
BIOCARTA DC PATHWAY 2220All SZGR 2.0 genes in this pathway
BIOCARTA ERYTH PATHWAY 1511All SZGR 2.0 genes in this pathway
BIOCARTA IL17 PATHWAY 1712All SZGR 2.0 genes in this pathway
BIOCARTA IL3 PATHWAY 1511All SZGR 2.0 genes in this pathway
BIOCARTA BAD PATHWAY 2623All SZGR 2.0 genes in this pathway
BIOCARTA STEM PATHWAY 1513All SZGR 2.0 genes in this pathway
PID NFAT TFPATHWAY 4739All SZGR 2.0 genes in this pathway
PID IL3 PATHWAY 2719All SZGR 2.0 genes in this pathway
PID TCR CALCIUM PATHWAY 2923All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 10786All SZGR 2.0 genes in this pathway
REACTOME IL 3 5 AND GM CSF SIGNALING 4334All SZGR 2.0 genes in this pathway
REACTOME IL RECEPTOR SHC SIGNALING 2721All SZGR 2.0 genes in this pathway
REACTOME IL 2 SIGNALING 4134All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
DEBOSSCHER NFKB TARGETS REPRESSED BY GLUCOCORTICOIDS 2418All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA UP 5035All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND TBH 6042All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK 7547All SZGR 2.0 genes in this pathway
RAY ALZHEIMERS DISEASE 137All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 8859All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway