Gene Page: IL4

Summary
GeneID  3565
Symbol  IL4
Synonyms  BCGF-1|BCGF1|BSF1|IL-4|MGC79402
Description  interleukin 4
See related  HGNC:6014|MIM:147780|Ensembl:ENSG00000113520|HPRD:00989|
Locus tag  -
Gene type  protein-coding
Map location  5q31.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.0032 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NPEPL10.750.65
SCNN1D0.750.68
AP1G20.740.67
HSF40.740.69
INHA0.730.59
COL7A10.720.62
ACCN30.710.69
MAN2C10.710.69
COL11A20.700.61
CPT1B0.700.64
Top 10 negatively co-expressed genes
GUCY1A2-0.30-0.23
PPM1L-0.27-0.15
AL512631.1-0.26-0.13
ABCD2-0.25-0.18
SEC62-0.25-0.28
SOX5-0.25-0.08
MOBKL3-0.24-0.24
GNAI1-0.24-0.17
PPM1E-0.24-0.14
UBE2K-0.24-0.24
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005136interleukin-4 receptor bindingTAS11418631 
GO:0005515protein bindingIPI8266078 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006968cellular defense responseTAS10725748 
GO:0008203cholesterol metabolic processISS11971948 
GO:0048304positive regulation of isotype switching to IgG isotypesISS-
GO:0006935chemotaxisTAS10725748 
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIEA-
GO:0043066negative regulation of apoptosisISS-
GO:0042325regulation of phosphorylationISS-
GO:0042104positive regulation of activated T cell proliferationIEA-
GO:0030890positive regulation of B cell proliferationISS-
GO:0042092T-helper 2 type immune responseTAS11676128 
GO:0048295positive regulation of isotype switching to IgE isotypesISS-
GO:0030183B cell differentiationTAS11418631 
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS-
GO:0045189connective tissue growth factor biosynthetic processTAS11967989 
GO:0045191regulation of isotype switchingTAS11418631 
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIEA-
GO:0050776regulation of immune responseISS-
GO:0045348positive regulation of MHC class II biosynthetic processISS-
GO:0045671negative regulation of osteoclast differentiationISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceTAS11418631 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
A2MCPAMD5 | DKFZp779B086 | FWP007 | S863-7alpha-2-macroglobulinReconstituted ComplexBioGRID10714547 
CD53MOX44 | TSPAN25CD53 molecule-HPRD7963560 
IL13RA2CD213A2 | IL-13R | IL13BPinterleukin 13 receptor, alpha 2-HPRD9130652 
IL2RGCD132 | IMD4 | SCIDX | SCIDX1interleukin 2 receptor, gamma (severe combined immunodeficiency)-HPRD,BioGRID8266078 
IL-4 interacts with gamma-C.BIND9799097 
IL4RCD124 | IL4RAinterleukin 4 receptor-HPRD,BioGRID11786020 
IL4R Interacts with IL4.BIND8266078 
IL4R -alpha(PDB ID: 1IAR_B) interacts with IL4(PDB ID: 1IAR_A).BIND10219247 
PIK3CDp110Dphosphoinositide-3-kinase, catalytic, delta polypeptide-HPRD9113989 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 7958All SZGR genes in this pathway
KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 4836All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_ASTHMA 3025All SZGR genes in this pathway
KEGG_AUTOIMMUNE_THYROID_DISEASE 5349All SZGR genes in this pathway
KEGG_ALLOGRAFT_REJECTION 3834All SZGR genes in this pathway
BIOCARTA_ASBCELL_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_CYTOKINE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_INFLAM_PATHWAY 2924All SZGR genes in this pathway
BIOCARTA_DC_PATHWAY 2220All SZGR genes in this pathway
BIOCARTA_GATA3_PATHWAY 1615All SZGR genes in this pathway
BIOCARTA_IL4_PATHWAY 118All SZGR genes in this pathway
BIOCARTA_IL5_PATHWAY 109All SZGR genes in this pathway
BIOCARTA_STEM_PATHWAY 1513All SZGR genes in this pathway
BIOCARTA_TOB1_PATHWAY 2114All SZGR genes in this pathway
BIOCARTA_NKT_PATHWAY 2921All SZGR genes in this pathway
BIOCARTA_TH1TH2_PATHWAY 1914All SZGR genes in this pathway
BIOCARTA_41BB_PATHWAY 1715All SZGR genes in this pathway
ST_INTERLEUKIN_4_PATHWAY 2618All SZGR genes in this pathway
PID_NOTCH_PATHWAY 5949All SZGR genes in this pathway
PID_IL4_2PATHWAY 6543All SZGR genes in this pathway
PID_CD40_PATHWAY 3126All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_NFAT_TFPATHWAY 4739All SZGR genes in this pathway
PID_REG_GR_PATHWAY 8260All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_IL2_STAT5_PATHWAY 3023All SZGR genes in this pathway
PID_TCR_CALCIUM_PATHWAY 2923All SZGR genes in this pathway
ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_UP 6344All SZGR genes in this pathway
DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS 2418All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
BRUNO_HEMATOPOIESIS 6648All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM 302191All SZGR genes in this pathway
JU_AGING_TERC_TARGETS_UP 106All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
BUDHU_LIVER_CANCER_METASTASIS_UP 107All SZGR genes in this pathway
ONO_AML1_TARGETS_DN 4125All SZGR genes in this pathway
ONO_FOXP3_TARGETS_DN 4223All SZGR genes in this pathway
WORSCHECH_TUMOR_EVASION_AND_TOLEROGENICITY_UP 3019All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB 14583All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-41045511Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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