Gene Page: IL4

Summary ?
GeneID3565
SymbolIL4
SynonymsBCGF-1|BCGF1|BSF-1|BSF1|IL-4
Descriptioninterleukin 4
ReferenceMIM:147780|HGNC:HGNC:6014|Ensembl:ENSG00000113520|HPRD:00989|Vega:OTTHUMG00000059724
Gene typeprotein-coding
Map location5q31.1
Pascal p-value0.248
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_IGenome scan meta-analysisPsr: 0.0032 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1382417chr327953633IL435650.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NPEPL10.750.65
SCNN1D0.750.68
AP1G20.740.67
HSF40.740.69
INHA0.730.59
COL7A10.720.62
ACCN30.710.69
MAN2C10.710.69
COL11A20.700.61
CPT1B0.700.64
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GUCY1A2-0.30-0.23
PPM1L-0.27-0.15
AL512631.1-0.26-0.13
ABCD2-0.25-0.18
SEC62-0.25-0.28
SOX5-0.25-0.08
MOBKL3-0.24-0.24
GNAI1-0.24-0.17
PPM1E-0.24-0.14
UBE2K-0.24-0.24

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005136interleukin-4 receptor bindingTAS11418631 
GO:0005515protein bindingIPI8266078 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006968cellular defense responseTAS10725748 
GO:0008203cholesterol metabolic processISS11971948 
GO:0048304positive regulation of isotype switching to IgG isotypesISS-
GO:0006935chemotaxisTAS10725748 
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIEA-
GO:0043066negative regulation of apoptosisISS-
GO:0042325regulation of phosphorylationISS-
GO:0042104positive regulation of activated T cell proliferationIEA-
GO:0030890positive regulation of B cell proliferationISS-
GO:0042092T-helper 2 type immune responseTAS11676128 
GO:0048295positive regulation of isotype switching to IgE isotypesISS-
GO:0030183B cell differentiationTAS11418631 
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS-
GO:0045189connective tissue growth factor biosynthetic processTAS11967989 
GO:0045191regulation of isotype switchingTAS11418631 
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIEA-
GO:0050776regulation of immune responseISS-
GO:0045348positive regulation of MHC class II biosynthetic processISS-
GO:0045671negative regulation of osteoclast differentiationISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceTAS11418631 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155105All SZGR 2.0 genes in this pathway
KEGG HEMATOPOIETIC CELL LINEAGE 8860All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY 7958All SZGR 2.0 genes in this pathway
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION 4836All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION 7256All SZGR 2.0 genes in this pathway
KEGG ASTHMA 3025All SZGR 2.0 genes in this pathway
KEGG AUTOIMMUNE THYROID DISEASE 5349All SZGR 2.0 genes in this pathway
KEGG ALLOGRAFT REJECTION 3834All SZGR 2.0 genes in this pathway
BIOCARTA ASBCELL PATHWAY 1211All SZGR 2.0 genes in this pathway
BIOCARTA CYTOKINE PATHWAY 2216All SZGR 2.0 genes in this pathway
BIOCARTA INFLAM PATHWAY 2924All SZGR 2.0 genes in this pathway
BIOCARTA DC PATHWAY 2220All SZGR 2.0 genes in this pathway
BIOCARTA GATA3 PATHWAY 1615All SZGR 2.0 genes in this pathway
BIOCARTA IL4 PATHWAY 118All SZGR 2.0 genes in this pathway
BIOCARTA IL5 PATHWAY 109All SZGR 2.0 genes in this pathway
BIOCARTA STEM PATHWAY 1513All SZGR 2.0 genes in this pathway
BIOCARTA TOB1 PATHWAY 2114All SZGR 2.0 genes in this pathway
BIOCARTA NKT PATHWAY 2921All SZGR 2.0 genes in this pathway
BIOCARTA TH1TH2 PATHWAY 1914All SZGR 2.0 genes in this pathway
BIOCARTA 41BB PATHWAY 1715All SZGR 2.0 genes in this pathway
ST INTERLEUKIN 4 PATHWAY 2618All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY 5949All SZGR 2.0 genes in this pathway
PID IL4 2PATHWAY 6543All SZGR 2.0 genes in this pathway
PID CD40 PATHWAY 3126All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 6354All SZGR 2.0 genes in this pathway
PID NFAT TFPATHWAY 4739All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY 8260All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 7060All SZGR 2.0 genes in this pathway
PID IL2 STAT5 PATHWAY 3023All SZGR 2.0 genes in this pathway
PID TCR CALCIUM PATHWAY 2923All SZGR 2.0 genes in this pathway
ROYLANCE BREAST CANCER 16Q COPY NUMBER UP 6344All SZGR 2.0 genes in this pathway
DEBOSSCHER NFKB TARGETS REPRESSED BY GLUCOCORTICOIDS 2418All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS 6648All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302191All SZGR 2.0 genes in this pathway
JU AGING TERC TARGETS UP 106All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163102All SZGR 2.0 genes in this pathway
BUDHU LIVER CANCER METASTASIS UP 107All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS DN 4125All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS DN 4223All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR EVASION AND TOLEROGENICITY UP 3019All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 14583All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-41045511Ahsa-miR-410AAUAUAACACAGAUGGCCUGU