Gene Page: IL18

Summary
GeneID  3606
Symbol  IL18
Synonyms  IGIF|IL-18|IL-1g|IL1F4|MGC12320
Description  interleukin 18 (interferon-gamma-inducing factor)
See related  HGNC:5986|MIM:600953|HPRD:02976|
Locus tag  -
Gene type  protein-coding
Map location  11q22.2-q22.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.006 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DCLK10.940.95
DLG30.940.94
MAPRE20.940.94
YWHAG0.930.95
ARHGEF70.930.95
ASTN10.910.92
LARP4B0.910.93
CEP680.910.93
C11orf410.900.93
ATRN0.900.92
Top 10 negatively co-expressed genes
FXYD1-0.71-0.70
AC021016.1-0.68-0.71
TLCD1-0.67-0.68
AP002478.3-0.67-0.73
AF347015.31-0.67-0.69
HIGD1B-0.67-0.70
ACSF2-0.67-0.70
MT-CO2-0.66-0.69
CLDN10-0.66-0.66
AF347015.21-0.66-0.72
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS8999896 
GO:0005149interleukin-1 receptor bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030431sleepISSBrain (GO term level: 3)11506998 
GO:0001525angiogenesisIDA11466388 
GO:0007267cell-cell signalingTAS9792649 
GO:0006955immune responseTAS8999896 
GO:0042095interferon-gamma biosynthetic processTAS10227975 
GO:0042094interleukin-2 biosynthetic processTAS10653850 
GO:0042231interleukin-13 biosynthetic processTAS10227975 
GO:0042253granulocyte macrophage colony-stimulating factor biosynthetic processTAS10653850 
GO:0030155regulation of cell adhesionIDA11477102 
GO:0042104positive regulation of activated T cell proliferationIDA8766574 |10000000 
GO:0042033chemokine biosynthetic processTAS11598150 
GO:0042088T-helper 1 type immune responseIDA8766574 
GO:0042092T-helper 2 type immune responseTAS11905033 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionTAS11598150 
GO:0005615extracellular spaceIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)Biochemical ActivityBioGRID12096920 
CASP4ICE(rel)II | ICEREL-II | ICH-2 | Mih1/TX | TXcaspase 4, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID12096920 
IL18BPIL18BPainterleukin 18 binding protein-HPRD,BioGRID11907126 
IL18R1CD218a | CDw218a | IL-1Rrp | IL18RA | IL1RRPinterleukin 18 receptor 1-HPRD9325300 
IL18RAPACPL | CD218b | CDw218b | IL18RB | MGC120589 | MGC120590interleukin 18 receptor accessory protein-HPRD9792649 
IL1RL2IL1R-rp2 | IL1RRP2interleukin 1 receptor-like 2-HPRD9325300 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 6247All SZGR genes in this pathway
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 5644All SZGR genes in this pathway
BIOCARTA_CYTOKINE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_IL12_PATHWAY 2317All SZGR genes in this pathway
BIOCARTA_NKCELLS_PATHWAY 2013All SZGR genes in this pathway
BIOCARTA_TH1TH2_PATHWAY 1914All SZGR genes in this pathway
PID_IL27_PATHWAY 2620All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_IL23_PATHWAY 3730All SZGR genes in this pathway
PID_ANTHRAX_PATHWAY 1715All SZGR genes in this pathway
PID_IL12_STAT4_PATHWAY 3329All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 205140All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
KIM_RESPONSE_TO_TSA_AND_DECITABINE_UP 12973All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_UP 8554All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_DN 12984All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_DN 209122All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP 316190All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_UP 14984All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP 185119All SZGR genes in this pathway
DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS 2418All SZGR genes in this pathway
YANAGIHARA_ESX1_TARGETS 3019All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_DN 193112All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_HIF1A_DN 11078All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_DN 10371All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_3 2823All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_1_UP 11866All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_UP 5035All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN 7748All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_UP 7149All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
GAJATE_RESPONSE_TO_TRABECTEDIN_UP 6745All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3 160103All SZGR genes in this pathway
GAVIN_PDE3B_TARGETS 2215All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
BASSO_HAIRY_CELL_LEUKEMIA_DN 8066All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_DN 14593All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
SWEET_KRAS_ONCOGENIC_SIGNATURE 8956All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS 4430All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G24 2819All SZGR genes in this pathway
WANG_METASTASIS_OF_BREAST_CANCER_ESR1_DN 3018All SZGR genes in this pathway
KAMIKUBO_MYELOID_CEBPA_NETWORK 2819All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
ISSAEVA_MLL2_TARGETS 6235All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_4 11066All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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