Gene Page: LNPEP

Summary ?
GeneID4012
SymbolLNPEP
SynonymsCAP|IRAP|P-LAP|PLAP
Descriptionleucyl/cystinyl aminopeptidase
ReferenceMIM:151300|HGNC:HGNC:6656|Ensembl:ENSG00000113441|HPRD:01041|HPRD:08255|Vega:OTTHUMG00000128719
Gene typeprotein-coding
Map location5q15
Pascal p-value0.005
DEG p-valueDEG:Sanders_2014:DS1_p=0.154:DS1_beta=0.020700:DS2_p=2.64e-01:DS2_beta=0.053:DS2_FDR=5.19e-01
Fetal beta-0.191
DMG2 (# studies)
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DEG:Sanders_2013MicroarrayWhole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg03635536596271340LNPEP2.039E-4-0.3050.035DMG:Wockner_2014
cg16189644596271684LNPEP4.64E-9-0.0142.7E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs149481chr596114345LNPEP40120.15cis
rs1230358chr596211740LNPEP40120cis
rs2549779chr596216386LNPEP40120.01cis
rs2549780chr596216783LNPEP40120.02cis
rs11135482chr596221425LNPEP40127.933E-5cis
rs2278019chr596225251LNPEP40120cis
rs10434709chr596225773LNPEP40129.233E-5cis
rs2548533chr596238400LNPEP40121.462E-5cis
rs2549794chr596244548LNPEP40120cis
rs7736466chr596289710LNPEP40126.621E-6cis
rs3909451chr596295120LNPEP40123.871E-4cis
rs27307chr596338504LNPEP40122.507E-4cis
rs27290chr596350087LNPEP40123.17E-4cis
rs27993chr596355602LNPEP40122.467E-4cis
rs27300chr596363406LNPEP40124.582E-4cis
rs1230358chr596211740LNPEP40120.12trans
rs11135482chr596221425LNPEP40120.01trans
rs2278019chr596225251LNPEP40120.2trans
rs10434709chr596225773LNPEP40120.01trans
rs2548533chr596238400LNPEP40120trans
rs2549794chr596244548LNPEP40120.09trans
rs7736466chr596289710LNPEP40120trans
rs3909451chr596295120LNPEP40120.03trans
rs27307chr596338504LNPEP40120.02trans
rs27290chr596350087LNPEP40120.03trans
rs27993chr596355602LNPEP40120.02trans
rs27300chr596363406LNPEP40120.04trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C1QTNF40.860.87
YDJC0.860.90
HSPBP10.850.84
SSBP40.840.88
SLC39A30.830.83
ZNF5800.820.87
GP1BB0.820.84
FBXW50.800.83
B4GALT20.800.77
NUDT16L10.790.83
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NSBP1-0.45-0.52
AL139819.3-0.45-0.48
AF347015.8-0.43-0.36
AF347015.18-0.43-0.38
MT-ATP8-0.42-0.39
AF347015.21-0.41-0.34
AF347015.26-0.41-0.35
EIF5B-0.41-0.49
AF347015.33-0.40-0.35
AF347015.2-0.40-0.32

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG RENIN ANGIOTENSIN SYSTEM 1710All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES 5141All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY 2624All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION 7648All SZGR 2.0 genes in this pathway
REACTOME ENDOSOMAL VACUOLAR PATHWAY 97All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251156All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212129All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP 165106All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP 12778All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418263All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329219All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176111All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN 11078All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN 12376All SZGR 2.0 genes in this pathway
BILD SRC ONCOGENIC SIGNATURE 6238All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP 163100All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200115All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
VISALA AGING LYMPHOCYTE UP 107All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S 14776All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 1 DN 6339All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824528All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway