Gene Page: MLLT1

Summary ?
GeneID4298
SymbolMLLT1
SynonymsENL|LTG19|YEATS1
Descriptionmyeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
ReferenceMIM:159556|HGNC:HGNC:7134|Ensembl:ENSG00000130382|HPRD:15933|Vega:OTTHUMG00000180757
Gene typeprotein-coding
Map location19p13.3
Pascal p-value0.049
Fetal beta0.24
DMG1 (# studies)
eGeneCerebellum
Myers' cis & trans
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg25825726196230459MLLT13.68E-50.2410.02DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1146358chr1116657767MLLT142984.167E-4trans
rs16854815chr1204931605MLLT142980.09trans
rs1934578chr1246016476MLLT142980.02trans
rs1934577chr1246016542MLLT142980trans
rs17012898chr233601648MLLT142980.19trans
rs17012916chr233606031MLLT142980.12trans
rs2716734chr239947720MLLT142981.093E-4trans
rs2716736chr239947946MLLT142981.093E-4trans
rs6754175chr2135333296MLLT142980.01trans
rs17039866chr34136543MLLT142980.13trans
rs11928084chr34138812MLLT142980.04trans
rs16850133chr3140030776MLLT142981.966E-5trans
rs7638929chr3140031075MLLT142980trans
rs2713946chr4111197804MLLT142980.08trans
rs16869878chr52523760MLLT142980.02trans
rs467856chr53128168MLLT142980trans
rs16902549chr513407346MLLT142980.04trans
rs1010527chr513508264MLLT142980.15trans
rs1992711chr513510917MLLT142980.15trans
rs16888245chr519737051MLLT142980.18trans
rs6451640chr520088127MLLT142980.03trans
snp_a-21696230MLLT142983.33E-5trans
rs6873234chr5169299967MLLT142980.01trans
rs73835480MLLT142980.01trans
rs2016128chr642442743MLLT142980.08trans
rs1587434chr666615354MLLT142986.025E-10trans
rs7746331chr684197931MLLT142980.19trans
rs4557559chr6118406801MLLT142980.02trans
rs4725268chr710334857MLLT142980.19trans
rs17154235chr726692981MLLT142980.16trans
rs4947631chr750603378MLLT142980trans
rs10257132chr751422943MLLT142980.01trans
rs529539chr784003500MLLT142980.03trans
rs10100949chr823865007MLLT142980.2trans
rs17051420chr823872203MLLT142980.13trans
snp_a-20641150MLLT142980.13trans
rs17051430chr823874554MLLT142980.13trans
rs7815377chr823874876MLLT142980.15trans
rs10503771chr825304019MLLT142980.07trans
rs2810511chr9136791540MLLT142980.03trans
rs10994470chr1051558659MLLT142980.04trans
rs16928875chr1073212531MLLT142980.12trans
rs17106311chr1087897271MLLT142980.14trans
rs17107175chr1088646323MLLT142980.04trans
rs1539587chr10115372155MLLT142980.08trans
rs7129903chr117775320MLLT142980.09trans
rs4944475chr1183985410MLLT142980.04trans
rs12270706chr11109947508MLLT142980.15trans
rs11183748chr1247516125MLLT142980.18trans
rs12423193chr1263753383MLLT142980.01trans
rs9888446chr1263785677MLLT142980trans
rs1400878chr1283609397MLLT142980trans
rs16945217chr12115679171MLLT142980trans
rs998923chr1335507810MLLT142983.034E-4trans
rs9590075chr1395414389MLLT142980.13trans
snp_a-22223550MLLT142980trans
rs2253509chr1528144975MLLT142980.12trans
rs7176277chr1563316182MLLT142980.18trans
rs6495316chr1578986100MLLT142980.06trans
rs1461211chr1588628773MLLT142980.06trans
rs2027819chr1619331736MLLT142980.13trans
rs12596294chr1672587092MLLT142980.16trans
rs1015663chr1714238086MLLT142980.07trans
rs295104chr1732814665MLLT142980.01trans
rs349973chr1750642288MLLT142980.18trans
rs8078127chr1750761342MLLT142980.01trans
rs10512600chr1772812978MLLT142986.264E-4trans
rs2661679chr1776172103MLLT142980trans
rs7217417chr1776173174MLLT142980trans
rs6040607chr2011371092MLLT142980.04trans
rs4270401chr2061343887MLLT142980.01trans
rs225434chr2143724740MLLT142980.13trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SPSB40.850.83
CD2760.850.88
EPHB20.840.81
PATZ10.840.84
CTNND10.830.80
F2R0.830.81
CCNF0.830.79
IPO40.830.83
MAPK70.830.87
U2AF20.820.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf53-0.64-0.77
HLA-F-0.60-0.66
CA4-0.58-0.68
AF347015.27-0.58-0.74
SLC16A11-0.58-0.59
CA11-0.58-0.71
AF347015.31-0.58-0.74
SPARCL1-0.58-0.63
AF347015.33-0.57-0.73
FXYD1-0.56-0.71

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
NADERI BREAST CANCER PROGNOSIS UP 5026All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463262All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP 163100All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C CLUSTER UP 3826All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA DN 6845All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA UP 6638All SZGR 2.0 genes in this pathway