Gene Page: NAGLU
Summary ?
| GeneID | 4669 |
| Symbol | NAGLU |
| Synonyms | CMT2V|MPS-IIIB|MPS3B|NAG|UFHSD |
| Description | N-acetylglucosaminidase, alpha |
| Reference | MIM:609701|HGNC:HGNC:7632|Ensembl:ENSG00000108784|HPRD:02017|Vega:OTTHUMG00000180240 |
| Gene type | protein-coding |
| Map location | 17q21 |
| Pascal p-value | 0.045 |
| Sherlock p-value | 0.154 |
| Fetal beta | -0.39 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg20623645 | 17 | 40687392 | NAGLU | 3.8E-4 | 0.283 | 0.043 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6917535 | chr6 | 100345316 | NAGLU | 4669 | 0.1 | trans | ||
| rs16967268 | chr15 | 39012761 | NAGLU | 4669 | 0.14 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LSMD1 | 0.94 | 0.88 |
| UQCRQ | 0.94 | 0.90 |
| ZNHIT1 | 0.93 | 0.83 |
| C7orf59 | 0.93 | 0.83 |
| NDUFB7 | 0.93 | 0.86 |
| MRPL54 | 0.93 | 0.87 |
| C19orf70 | 0.93 | 0.83 |
| UQCR | 0.92 | 0.84 |
| C6orf125 | 0.92 | 0.80 |
| NDUFA13 | 0.92 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KIF16B | -0.50 | -0.55 |
| MACF1 | -0.49 | -0.56 |
| ZC3H13 | -0.48 | -0.49 |
| BAT2D1 | -0.48 | -0.47 |
| FNBP1 | -0.47 | -0.53 |
| UPF2 | -0.47 | -0.44 |
| MDN1 | -0.47 | -0.48 |
| MAP4K4 | -0.47 | -0.56 |
| MYH9 | -0.47 | -0.41 |
| GOLGB1 | -0.47 | -0.47 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004561 | alpha-N-acetylglucosaminidase activity | TAS | 8650226 | |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007399 | nervous system development | TAS | neurite (GO term level: 5) | 8650226 |
| GO:0008152 | metabolic process | IEA | - | |
| GO:0030203 | glycosaminoglycan metabolic process | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005764 | lysosome | TAS | 8650226 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLYCOSAMINOGLYCAN DEGRADATION | 21 | 14 | All SZGR 2.0 genes in this pathway |
| KEGG LYSOSOME | 121 | 83 | All SZGR 2.0 genes in this pathway |
| REACTOME HS GAG DEGRADATION | 20 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM | 52 | 33 | All SZGR 2.0 genes in this pathway |
| REACTOME GLYCOSAMINOGLYCAN METABOLISM | 111 | 69 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF CARBOHYDRATES | 247 | 154 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS UP | 473 | 314 | All SZGR 2.0 genes in this pathway |
| HUTTMANN B CLL POOR SURVIVAL UP | 276 | 187 | All SZGR 2.0 genes in this pathway |
| RODRIGUES NTN1 TARGETS DN | 158 | 102 | All SZGR 2.0 genes in this pathway |
| UDAYAKUMAR MED1 TARGETS UP | 135 | 82 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
| FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN | 98 | 59 | All SZGR 2.0 genes in this pathway |
| KUMAR TARGETS OF MLL AF9 FUSION | 405 | 264 | All SZGR 2.0 genes in this pathway |
| LEE CALORIE RESTRICTION NEOCORTEX DN | 88 | 58 | All SZGR 2.0 genes in this pathway |
| KAYO CALORIE RESTRICTION MUSCLE UP | 95 | 64 | All SZGR 2.0 genes in this pathway |
| BREDEMEYER RAG SIGNALING NOT VIA ATM DN | 57 | 34 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA CHEMOTAXIS DN | 457 | 302 | All SZGR 2.0 genes in this pathway |
| ZHAN V1 LATE DIFFERENTIATION GENES UP | 32 | 25 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP | 271 | 165 | All SZGR 2.0 genes in this pathway |