Gene Page: NKG7

Summary ?
GeneID4818
SymbolNKG7
SynonymsGIG1|GMP-17|p15-TIA-1
Descriptionnatural killer cell granule protein 7
ReferenceMIM:606008|HGNC:HGNC:7830|Ensembl:ENSG00000105374|HPRD:16188|Vega:OTTHUMG00000182898
Gene typeprotein-coding
Map location19q13.41
Pascal p-value0.181
Fetal beta-0.308
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 7

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg159102081951522588NKG70.00110.713DMG:vanEijk_2014
cg172156801951920976NKG72.247E-49.727DMG:vanEijk_2014
cg088187841956566846-56566895NKG73.194E-49.176DMG:vanEijk_2014
cg114597141951520658NKG78.563E-47.978DMG:vanEijk_2014
cg124917101951891526NKG71.64E-5-7.494DMG:vanEijk_2014
cg043497271951457389NKG72.72E-5-9.86DMG:vanEijk_2014
cg144963751951872365NKG73.3E-9-15.781DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MEN10.960.96
RANBP30.960.97
CIZ10.960.96
DNMT10.960.96
RBM100.950.96
SF10.950.95
ZNF7770.950.96
DVL30.950.95
UNK0.950.96
EHMT20.950.95
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.78-0.86
MT-CO2-0.76-0.85
AF347015.27-0.75-0.84
AF347015.33-0.74-0.81
MT-CYB-0.73-0.81
AF347015.21-0.72-0.90
FXYD1-0.72-0.80
C5orf53-0.72-0.75
AF347015.8-0.71-0.82
HIGD1B-0.71-0.82

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
WILCOX RESPONSE TO PROGESTERONE UP 15290All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 11679All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320184All SZGR 2.0 genes in this pathway
LIU TARGETS OF VMYB VS CMYB DN 4330All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS UP 8140All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418263All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187115All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM DN 4226All SZGR 2.0 genes in this pathway
DUNNE TARGETS OF AML1 MTG8 FUSION UP 5232All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
ROSS AML WITH MLL FUSIONS 7845All SZGR 2.0 genes in this pathway
PARK HSC MARKERS 4431All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T7 9863All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G 17196All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252155All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315201All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
ROSS LEUKEMIA WITH MLL FUSIONS 7849All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM RISK DN 2312All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO MERCAPTOPURINE AND HD MTX DN 2518All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE UP 6242All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS UP 6643All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS UP 2414All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA1 UP 10166All SZGR 2.0 genes in this pathway
HAHTOLA CTCL PATHOGENESIS 169All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307182All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397206All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321200All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 11462All SZGR 2.0 genes in this pathway