Gene Page: OXT

Summary ?
GeneID5020
SymbolOXT
SynonymsOT|OT-NPI|OXT-NPI
Descriptionoxytocin/neurophysin I prepropeptide
ReferenceMIM:167050|HGNC:HGNC:8528|Ensembl:ENSG00000101405|HPRD:08880|Vega:OTTHUMG00000031724
Gene typeprotein-coding
Map location20p13
Pascal p-value0.244
Fetal beta-0.57
eGeneMyers' cis & trans
Meta
SupportNEUROTROPHIN SIGNALING
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2494875chr150652317OXT50200.04trans
rs6688407chr1111796110OXT50200.04trans
rs17047497chr256347610OXT50200.03trans
rs11679895chr2104914347OXT50200.13trans
rs17203661chr48527262OXT50200.18trans
rs13146859chr48528027OXT50200.19trans
rs17211228chr581742122OXT50200.06trans
rs2546197chr595172280OXT50200.15trans
rs9371139chr6169955205OXT50200.07trans
rs4391437chr89373515OXT50200.08trans
rs6601322chr89375852OXT50200.02trans
rs17062725chr979168620OXT50201.405E-5trans
rs17824714chr1265764276OXT50200.13trans
rs6581637chr1265852923OXT50200.13trans
rs12585923chr1376625287OXT50200.15trans
rs1330442chr1376680920OXT50200.04trans
rs1499605chr1563706224OXT50200.08trans
rs289811chr1563710672OXT50200.02trans
rs16953493chr173714057OXT50200.05trans
rs16953498chr173719619OXT50200.06trans
rs1183148chr173733846OXT50200.04trans
rs7272436chr2052558686OXT50200.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RAB9A0.680.72
AKR7A20.680.66
FUCA20.650.66
MRPL400.650.62
TMEM590.640.66
FAM96A0.640.54
C2orf280.640.62
SRI0.640.64
GRHPR0.630.63
SDHC0.630.62
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
JAG2-0.41-0.40
BAT2D1-0.40-0.43
CACNA1C-0.40-0.35
HIVEP3-0.39-0.33
CACNA1B-0.39-0.34
ADCY1-0.39-0.29
XKR4-0.37-0.30
MYT1L-0.37-0.31
AL391628.1-0.36-0.38
TNRC6C-0.36-0.34

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN 8659All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX UP 8959All SZGR 2.0 genes in this pathway
MATZUK POST-IMPLANTATION AND POST-PARTUM 1413All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER WITH EPCAM UP 5325All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME2 AND H3K27ME3 5935All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway