Summary ?
GeneID5058
SymbolPAK1
SynonymsPAKalpha
Descriptionp21 protein (Cdc42/Rac)-activated kinase 1
ReferenceMIM:602590|HGNC:HGNC:8590|Ensembl:ENSG00000149269|HPRD:03995|Vega:OTTHUMG00000165138
Gene typeprotein-coding
Map location11q13.5-q14.1
Pascal p-value0.977
Fetal beta-1.603
eGeneMyers' cis & trans
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.6755 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6902183chr6121963786PAK150580.17trans
rs7132043chr1280968399PAK150580.12trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RARB0.930.48
EBF10.930.41
IKZF10.920.52
ZNF5210.910.61
C10orf410.910.33
DLX60.900.54
PDYN0.890.35
TSPAN90.880.56
GPR1490.880.53
NTN10.880.44
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CHPT1-0.24-0.25
PTH1R-0.23-0.35
C5orf53-0.22-0.33
AF347015.31-0.22-0.49
COPZ2-0.22-0.41
RTN4RL2-0.220.06
COX4I2-0.22-0.45
C1S-0.22-0.02
MUSTN1-0.22-0.38
CA4-0.22-0.33

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI12624090 |12879077 |15350535 
|16278681 |18086875 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityTAS16278681 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007528neuromuscular junction developmentIEASynap (GO term level: 10)-
GO:0016358dendrite developmentIEAneurite, dendrite (GO term level: 11)-
GO:0000165MAPKKK cascadeIDA8805275 
GO:0007010cytoskeleton organizationTAS16278681 
GO:0006984ER-nuclear signaling pathwayTAS16278681 
GO:0006915apoptosisIEA-
GO:0043507positive regulation of JNK activityIMP8805275 
GO:0043113receptor clusteringIEA-
GO:0046777protein amino acid autophosphorylationIDA8805275 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030426growth coneIEAaxon, dendrite (GO term level: 5)-
GO:0030424axonIEAneuron, axon, Neurotransmitter (GO term level: 6)-
GO:0005794Golgi apparatusIDA18029348 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIDA16278681 
GO:0005886plasma membraneIDA16278681 
GO:0030054cell junctionIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI3NESH | SSH3BP3ABI family, member 3-HPRD,BioGRID11956071 
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1Reconstituted ComplexBioGRID14749719 
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alphaPak1 interacts with and phosphorylates RhoGDI. This interaction was modeled on a demonstrated interaction between Pak1 from an unspecified species and human RhoGDI.BIND15225553 
ARHGEF2DKFZp547L106 | DKFZp547P1516 | GEF | GEF-H1 | GEFH1 | KIAA0651 | LFP40 | P40rho/rac guanine nucleotide exchange factor (GEF) 2Affinity Capture-MS
Reconstituted Complex
BioGRID14970201 
ARHGEF6COOL2 | Cool-2 | KIAA0006 | MRX46 | PIXA | alpha-PIX | alphaPIXRac/Cdc42 guanine nucleotide exchange factor (GEF) 6-HPRD,BioGRID9659915 
ARHGEF7BETA-PIX | COOL1 | DKFZp686C12170 | DKFZp761K1021 | KIAA0142 | KIAA0412 | Nbla10314 | P50 | P50BP | P85 | P85COOL1 | P85SPR | PAK3 | PIXBRho guanine nucleotide exchange factor (GEF) 7-HPRD,BioGRID11157752|12006652 
ARPC1BARC41 | p40-ARC | p41-ARCactin related protein 2/3 complex, subunit 1B, 41kDa-HPRD,BioGRID14749719 
BAIAP2BAP2 | IRSP53BAI1-associated protein 2Reconstituted ComplexBioGRID11130076 
BMXETK | PSCTK2 | PSCTK3BMX non-receptor tyrosine kinase-HPRD,BioGRID11382770 
CDC2L2CDC2L3 | CDK11-p110 | CDK11-p46 | CDK11-p58 | MGC131975 | PITSLRE | p58GTAcell division cycle 2-like 2 (PITSLRE proteins)-HPRD,BioGRID12624090 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)Reconstituted ComplexBioGRID12650940 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)PAK1 interacts with an unspecified isoform of Cdc42. This interaction was modeled on a demonstrated interaction between PAK1 from an unspecified species and human Cdc42.BIND15864311 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD7744004 |8107774 
|9705280|9705280 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)Cdc42 interacts with Pak1. This interaction was modelled on a demonstrated interaction between Cdc42 from an unspecified species and human Pak1.BIND12944407 
CDK5PSSALREcyclin-dependent kinase 5Affinity Capture-Western
Biochemical Activity
BioGRID11604394 
CDK5R1CDK5P35 | CDK5R | MGC33831 | NCK5A | p23 | p25 | p35 | p35nck5acyclin-dependent kinase 5, regulatory subunit 1 (p35)-HPRD11604394 
COL1A1OI4collagen, type I, alpha 1-HPRD,BioGRID10772928 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD10938077 
CSNK2A2CK2A2 | CSNK2A1 | FLJ43934casein kinase 2, alpha prime polypeptide-HPRD10938077 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1Affinity Capture-Western
Biochemical Activity
Reconstituted Complex
Two-hybrid
BioGRID15193260 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Tyrosine-phosphorylated EGFR interacts with PAK1.BIND12522133 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD,BioGRID9774445 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2PAK1 interacts with Grb2.BIND12522133 
HGSHRS | ZFYVE8hepatocyte growth factor-regulated tyrosine kinase substrate-HPRD,BioGRID11397816 
HIST4H4H4/p | MGC24116histone cluster 4, H4PAK1 phosphorylates H4. This interaction was modeled on a demonstrated interaction between human PAK1 and H4 from an unspecified species.BIND15864311 
LIMK1LIMKLIM domain kinase 1-HPRD,BioGRID10559936 
MYLKDKFZp686I10125 | FLJ12216 | KRP | MLCK | MLCK1 | MLCK108 | MLCK210 | MSTP083 | MYLK1 | smMLCKmyosin light chain kinase-HPRD,BioGRID10092231 
NCF1CSH3PXD1Cneutrophil cytosolic factor 1C pseudogenePak1 interacts with and phosphorylates P47. This interaction was modeled on a demonstrated interaction between Pak1 and P47 from unspecified species.BIND15225553 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD8824201 |11278241 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1Nck interacts with PAK1BIND8824201 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD,BioGRID8824201 
NCK2GRB4 | NCKbetaNCK adaptor protein 2-HPRD,BioGRID10026169 |11557983 
NF2ACN | BANF | SCHneurofibromin 2 (merlin)Merlin interacts with Pak1BIND14580336 
NF2ACN | BANF | SCHneurofibromin 2 (merlin)-HPRD14580336 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1-HPRD,BioGRID11804587 
PAK1IP1FLJ20624 | MAK11 | PIP1 | RP11-421M1.5 | WDR84 | bA421M1.5 | hPIP1PAK1 interacting protein 1-HPRD,BioGRID11371639 
PKLRPK1 | PKL | PKR | PKRL | RPKpyruvate kinase, liver and RBCAffinity Capture-WesternBioGRID12006652 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID12085993 
PPM1FCaMKPase | FEM-2 | KIAA0015 | POPX2 | hFEM-2protein phosphatase 1F (PP2C domain containing)-HPRD11864573 
PXNFLJ16691paxillin-HPRD10330411 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)PAK1 interacts with an unspecified isoform of Rac. This interaction was modeled on a demonstrated interaction between human PAK1 and Rac from Chinese hamster.BIND15975516 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)PAK1 interacts with an unspecified isoform of Rac. This interaction was modeled on a demonstrated interaction between PAK1 from an unspecified species and human Rac.BIND15864311 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD7744004 |8107774 
|11134022 |11950930|11134022 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Reconstituted ComplexBioGRID12650940 |12879077 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Active GTP-bound RAC1 interacts with PAK1B. This interaction was modelled on a demonstrated interaction between chicken RAC1 and human PAK1B.BIND15735674 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Rac1 interacts with Pak1. This interaction was modeled on a demonstrated interaction between Rac1 and Pak1 from an unspecified species.BIND15652748 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Rac1 interacts with Pak1. This interaction was modelled on a demonstrated interacton between Rac1 from an unspecified species and human Pak1.BIND12944407 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1-HPRD,BioGRID11733498 
RHOJARHJ | FLJ14445 | MGC34777 | RASL7B | TC10B | TCLras homolog gene family, member J-HPRD,BioGRID10967094 
RHOUARHU | CDC42L1 | DJ646B12.2 | FLJ10616 | WRCH1 | fJ646B12.2 | hG28Kras homolog gene family, member UWrch-1 interacts with PAK. This interaction was modeled on a demonstrated interactions between human Wrch-1 and rat PAK.BIND15556869 
SPENKIAA0929 | MINT | RP1-134O19.1 | SHARPspen homolog, transcriptional regulator (Drosophila)Pak1 phosphorylates SHARP. This interaction was modeled on a demonstrated interaction between Pak1 and SHARP both from an unspecified species.BIND15824732 
TGFBR2AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RIItransforming growth factor, beta receptor II (70/80kDa)T-beta-RII interacts with PAK1. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse PAK1.BIND15761153 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY 8771All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129103All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 13792All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 9771All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 6844All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 7060All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY 3631All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY 3628All SZGR 2.0 genes in this pathway
BIOCARTA FAS PATHWAY 3022All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY 3929All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY 2623All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY 3124All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 8768All SZGR 2.0 genes in this pathway
BIOCARTA RAC1 PATHWAY 2316All SZGR 2.0 genes in this pathway
BIOCARTA NKCELLS PATHWAY 2013All SZGR 2.0 genes in this pathway
BIOCARTA CDC42RAC PATHWAY 1613All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY 3730All SZGR 2.0 genes in this pathway
BIOCARTA TNFR1 PATHWAY 2921All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES 6754All SZGR 2.0 genes in this pathway
SIG CHEMOTAXIS 4537All SZGR 2.0 genes in this pathway
SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES 3525All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY 8262All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION 4533All SZGR 2.0 genes in this pathway
PID MET PATHWAY 8060All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 4038All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY 3125All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 7051All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY 5041All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY 3227All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 10278All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY 3529All SZGR 2.0 genes in this pathway
PID PLK1 PATHWAY 4625All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
PID AURORA A PATHWAY 3120All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY 2419All SZGR 2.0 genes in this pathway
PID EPHA2 FWD PATHWAY 1916All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY 5437All SZGR 2.0 genes in this pathway
PID FAK PATHWAY 5945All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION 12077All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING 5446All SZGR 2.0 genes in this pathway
REACTOME GENERATION OF SECOND MESSENGER MOLECULES 2725All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251188All SZGR 2.0 genes in this pathway
REACTOME CD28 CO STIMULATION 3226All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF RAC 1411All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION 1514All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT VAV1 PATHWAY 1110All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS 6853All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 6348All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ROBO RECEPTOR 3026All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS 8662All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1 3425All SZGR 2.0 genes in this pathway
REACTOME DSCAM INTERACTIONS 1110All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276187All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805505All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
CHIN BREAST CANCER COPY NUMBER UP 2718All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
SNIJDERS AMPLIFIED IN HEAD AND NECK TUMORS 3727All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164111All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS DN 2417All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290172All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU DN 8369All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON 15893All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA HP UP 4926All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153120All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C1 1915All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1 5843All SZGR 2.0 genes in this pathway
WU HBX TARGETS 3 DN 139All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 8858All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264168All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469239All SZGR 2.0 genes in this pathway
MCCABE HOXC6 TARGETS DN 2115All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
CLIMENT BREAST CANCER COPY NUMBER UP 2320All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
RAY TARGETS OF P210 BCR ABL FUSION DN 1611All SZGR 2.0 genes in this pathway
WALLACE JAK2 TARGETS UP 2615All SZGR 2.0 genes in this pathway
LEE RECENT THYMIC EMIGRANT 227128All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS UP 2414All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS UP 2315All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237159All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306191All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222147All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321200All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS DN 14888All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428246All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS DN 1910All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/9810891095m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-1505545601Ahsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-221/2226596661A,m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-34b12021208m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-376c6576631Ahsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-485-5p15221A,m8hsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-962531m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC