Gene Page: PAWR

Summary
GeneID  5074
Symbol  PAWR
Synonyms  PAR4|Par-4
Description  PRKC, apoptosis, WT1, regulator
See related  HGNC:8614|MIM:601936|Ensembl:ENSG00000177425|HPRD:09051|
Locus tag  -
Gene type  protein-coding
Map location  12q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PCCB0.620.67
ENO10.590.63
SDHD0.590.63
TRIM210.590.39
TEX2640.590.67
PRCP0.580.59
CYB5R10.570.57
COQ90.560.56
TMX20.560.61
GCAT0.560.61
Top 10 negatively co-expressed genes
AC005921.3-0.38-0.55
AC109829.1-0.35-0.34
SFRS18-0.35-0.51
ZNF814-0.34-0.41
AL391628.1-0.34-0.36
AC073995.1-0.33-0.42
AC132872.1-0.33-0.38
ARGLU1-0.33-0.46
AL953897.2-0.32-0.25
C21orf32-0.32-0.37
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003714transcription corepressor activityTAS8943350 
GO:0019899enzyme bindingIDA15671026 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterTAS8943350 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0008285negative regulation of cell proliferationTAS8943350 
GO:0043065positive regulation of apoptosisNAS11585763 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusNAS-
GO:0005737cytoplasmNAS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AATFCHE-1 | CHE1 | DEDapoptosis antagonizing transcription factor-HPRD,BioGRID14627703 
DAPK3FLJ36473 | ZIP | ZIPKdeath-associated protein kinase 3Affinity Capture-Western
Biochemical Activity
Two-hybrid		BioGRID12917339 
PAWRPAR4 | Par-4PRKC, apoptosis, WT1, regulatorPar-4 forms a homodimer.BIND8797824 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD12717420 
PRKCIDXS1179E | MGC26534 | PKCI | nPKC-iotaprotein kinase C, iotaPar-4 interacts with PKC-lambda/iota. This interaction was modelled on a demonstrated interaction between human Par-4 and Xenopus laevis PKC-lambda/iota.BIND8797824 
PRKCZPKC-ZETA | PKC2protein kinase C, zetaPar-4 interacts with PKC-zeta. This interaction was modelled on a demonstrated interaction between human Par-4 and rat PKC-zeta.BIND8797824 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID8797824 
SLC5A1D22S675 | NAGT | SGLT1solute carrier family 5 (sodium/glucose cotransporter), member 1Affinity Capture-WesternBioGRID15090548 
SLC5A7CHT | CHT1 | MGC126299 | MGC126300 | hCHTsolute carrier family 5 (choline transporter), member 7-HPRD,BioGRID15090548 
THAP1FLJ10477 | MGC33014THAP domain containing, apoptosis associated protein 1-HPRD,BioGRID12717420 
WT1GUD | WAGR | WIT-2 | WT33Wilms tumor 1-HPRD,BioGRID8943350 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PID_CERAMIDE_PATHWAY 4837All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP 9459All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_UP 13582All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP 5540All SZGR genes in this pathway
BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN 4834All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_DN 6745All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP 271175All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_UP 11668All SZGR genes in this pathway
BUSA_SAM68_TARGETS_UP 76All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 153102All SZGR genes in this pathway
LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_SMALL_VS_HUGE_UP 3829All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP 283177All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
STANELLE_E2F1_TARGETS 2920All SZGR genes in this pathway
KIM_GERMINAL_CENTER_T_HELPER_UP 6642All SZGR genes in this pathway
KLEIN_PRIMARY_EFFUSION_LYMPHOMA_DN 5842All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
RORIE_TARGETS_OF_EWSR1_FLI1_FUSION_UP 3022All SZGR genes in this pathway
JAIN_NFKB_SIGNALING 7544All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_UP 180125All SZGR genes in this pathway
BURTON_ADIPOGENESIS_11 5740All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
HAN_JNK_SINGALING_DN 3927All SZGR genes in this pathway
MULLIGAN_NTF3_SIGNALING_VIA_INSR_AND_IGF1R_DN 136All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
MCCABE_HOXC6_TARGETS_CANCER_DN 2012All SZGR genes in this pathway
BASSO_HAIRY_CELL_LEUKEMIA_UP 65All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
VALK_AML_CLUSTER_10 3322All SZGR genes in this pathway
VALK_AML_WITH_EVI1 2515All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA1_UP 10166All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_DN 8766All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
STAMBOLSKY_TARGETS_OF_MUTATED_TP53_UP 4935All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1814551m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-265946011A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-30-5p3493561A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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