Gene Page

Gene Page: SHANK1

Summary

GeneID

50944

Symbol

SHANK1

Synonyms

SPANK-1|SSTRIP|synamon

Description

SH3 and multiple ankyrin repeat domains 1

Locus tag

Gene type

protein-coding

Map location

19q13.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 2

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0923

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IPI

10551867 |11583995

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007016

cytoskeletal anchoring at plasma membrane

NAS

10551867

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0030425

dendrite

NAS

neuron, axon, dendrite (GO term level: 6)

10551867

GO:0045211

postsynaptic membrane

IEA

Synap, Neurotransmitter (GO term level: 5)

GO:0045202

synapse

IEA

neuron, Synap, Neurotransmitter, Glial (GO term level: 2)

GO:0005622

intracellular

NAS

10551867

GO:0005624

membrane fraction

IDA

10551867

GO:0005737

cytoplasm

IEA

GO:0005886

plasma membrane

IEA

GO:0030054

cell junction

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARHGEF7	BETA-PIX \| COOL1 \| DKFZp686C12170 \| DKFZp761K1021 \| KIAA0142 \| KIAA0412 \| Nbla10314 \| P50 \| P50BP \| P85 \| P85COOL1 \| P85SPR \| PAK3 \| PIXB	Rho guanine nucleotide exchange factor (GEF) 7	-	HPRD,BioGRID	12626503
BAI2	-	brain-specific angiogenesis inhibitor 2	-	HPRD,BioGRID	10964907
BAIAP2	BAP2 \| IRSP53	BAI1-associated protein 2	-	HPRD,BioGRID	12504591
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	-	HPRD,BioGRID	10433268
DLGAP1	DAP-1 \| DAP-1-ALPHA \| DAP-1-BETA \| GKAP \| MGC88156 \| SAPAP1 \| hGKAP	discs, large (Drosophila) homolog-associated protein 1	Co-crystal Structure	BioGRID	12954649
DNM2	CMTDI1 \| CMTDIB \| DI-CMTB \| DYN2 \| DYNII	dynamin 2	-	HPRD,BioGRID	11583995
LPHN1	CIRL1 \| CL1 \| LEC2	latrophilin 1	CIRL1 interacts with SSTRIP. This interaction was modeled on a demonstrated interaction between CIRL1 from an unspecified species and human SSTRIP .	BIND	10964907
LPHN1	CIRL1 \| CL1 \| LEC2	latrophilin 1	Two-hybrid	BioGRID	10964907
LPHN2	CIRL2 \| CL2 \| LEC1 \| LPHH1	latrophilin 2	Two-hybrid	BioGRID	10964907
SHANK1	SPANK-1 \| SSTRIP \| synamon	SH3 and multiple ankyrin repeat domains 1	-	HPRD,BioGRID	12954649
SHARPIN	DKFZp434N1923 \| SIPL1	SHANK-associated RH domain interactor	-	HPRD,BioGRID	11178875 \|12753155
SPTAN1	(ALPHA)II-SPECTRIN \| FLJ44613 \| NEAS	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	-	HPRD,BioGRID	11509555
SSTR2	-	somatostatin receptor 2	-	HPRD,BioGRID	10551867
TANC1	KIAA1728 \| ROLSB \| TANC	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	-	HPRD	15673434

Pathway annotation

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-184	24	30	1A	hsa-miR-184	UGGACGGAGAACUGAUAAGGGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.