Gene Page: PCDH8

Summary ?
GeneID5100
SymbolPCDH8
SynonymsARCADLIN|PAPC
Descriptionprotocadherin 8
ReferenceMIM:603580|HGNC:HGNC:8660|Ensembl:ENSG00000136099|HPRD:04660|Vega:OTTHUMG00000016979
Gene typeprotein-coding
Map location13q21.1
Pascal p-value2.078E-5
Fetal beta-0.882
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg098236791353425813PCDH81.02E-7-0.012.25E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001756somitogenesisIEA-
GO:0007155cell adhesionIEA-
GO:0007156homophilic cell adhesionIEA-
GO:0007267cell-cell signalingTAS9787079 
GO:0016331morphogenesis of embryonic epitheliumIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneTAS9787079 
GO:0005887integral to plasma membraneTAS9787079 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
LEE NEURAL CREST STEM CELL UP 14699All SZGR 2.0 genes in this pathway
PACHER TARGETS OF IGF1 AND IGF2 UP 3527All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR DN 5745All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
STAEGE EWING FAMILY TUMOR 3322All SZGR 2.0 genes in this pathway
SUZUKI RESPONSE TO TSA AND DECITABINE 1A 2316All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428266All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS 4728All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 142103All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210148All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448282All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239156All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101140146m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-124.197103m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506961031A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-129-5p3743801Ahsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-141/200a6874m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-15386921Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-1823503571A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-200bc/429198204m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-2171962021Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-218549555m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-314534591Ahsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-3812932991Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-410312318m8hsa-miR-410AAUAUAACACAGAUGGCCUGU
hsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-44885921A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-4521551621A,m8hsa-miR-452UGUUUGCAGAGGAAACUGAGAC
miR-4953093151Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-963513571Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC