Gene Page: SERPINA5

Summary
GeneID  5104
Symbol  SERPINA5
Synonyms  PAI3|PCI|PLANH3|PROCI
Description  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
See related  HGNC:8723|MIM:601841|Ensembl:ENSG00000188488|HPRD:03503|
Locus tag  -
Gene type  protein-coding
Map location  14q32.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 2.04 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
STT3B0.870.72
DOK60.860.82
ARSK0.840.71
ST6GALNAC30.830.72
LCORL0.820.65
VRK10.820.65
HCRTR20.810.58
C14orf230.810.58
RNF1380.800.65
C5orf230.800.68
Top 10 negatively co-expressed genes
HSD17B14-0.46-0.59
MT-CO2-0.46-0.60
SLC7A10-0.46-0.66
S100A16-0.46-0.60
RAB34-0.46-0.59
VEGFB-0.46-0.50
C19orf36-0.46-0.54
LIMS2-0.46-0.50
MT-CYB-0.45-0.59
PARP10-0.45-0.45
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004867serine-type endopeptidase inhibitor activityIDA7521127 
GO:0005515protein bindingIEA-
GO:0008201heparin bindingTAS11120760 
GO:0032190acrosin bindingIPI7521127 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007283spermatogenesisISS-
GO:0007342fusion of sperm to egg plasma membraneNAS9510955 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS14718574 
GO:0005576extracellular regionTAS11120760 
GO:0016020membraneIDA7521127 
GO:0043234protein complexIDA7521127 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACR-acrosin-HPRD,BioGRID7521127 
COPS6CSN6 | MOV34-34KDCOP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)Two-hybridBioGRID16169070 
F10FX | FXAcoagulation factor X-HPRD2551064 
F11FXI | MGC141891coagulation factor XI-HPRD,BioGRID2551064 
F2PTcoagulation factor II (thrombin)-HPRD12878585 
FGAFib2 | MGC119422 | MGC119423 | MGC119425fibrinogen alpha chain-HPRD,BioGRID8384496 |8589203 
FGBMGC104327 | MGC120405fibrinogen beta chain-HPRD,BioGRID8148485 |8384496 
FGG-fibrinogen gamma chain-HPRD8384496 
KLK1KLKR | Klk6 | hK1kallikrein 1-HPRD9368023 
KLK2KLK2A2 | MGC12201 | hK2kallikrein-related peptidase 2Affinity Capture-WesternBioGRID9016396 
-HPRD9368023 
KLK3APS | KLK2A1 | PSA | hK3kallikrein-related peptidase 3-HPRD,BioGRID7509746 |8665956 
|8732755 
KLKB1KLK3 | PPKkallikrein B, plasma (Fletcher factor) 1-HPRD,BioGRID2551064 |11864713 
PLATDKFZp686I03148 | T-PA | TPAplasminogen activator, tissue-HPRD,BioGRID2551064 
PLAUATF | UPA | URK | UROKINASE | u-PAplasminogen activator, urokinaseReconstituted ComplexBioGRID2551064 |2752144 
-HPRD2752144 |9365930 
PROCPC | PROC1protein C (inactivator of coagulation factors Va and VIIIa)-HPRD,BioGRID11123896 
SEMG2SGIIsemenogelin II-HPRD8665956 
THBDCD141 | THRM | TMthrombomodulin-HPRD12878585 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 6949All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_UP 11272All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP 266171All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
NIELSEN_SCHWANNOMA_UP 1816All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN 14294All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
MASSARWEH_RESPONSE_TO_ESTRADIOL 6147All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BRAIN_DN 8558All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_UP 9761All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
MATZUK_MALE_REPRODUCTION_SERTOLI 2823All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_DN 3125All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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